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Results for "

serotonin reuptake

" in MedChemExpress (MCE) Product Catalog:

標的別:	5-HT Receptor (52) Serotonin Transporter (150) Adrenergic Receptor (35) Akt (5) Antifolate (1) Apoptosis (5) Autophagy (16) Calcium Channel (2) Cholinesterase (ChE) (1) Cytochrome P450 (2) Dopamine Receptor (8) Dopamine Transporter (17) Drug Intermediate (1) Drug Metabolite (13) G Protein-coupled Receptor Kinase (GRK) (5) GlyT (1) Histamine Receptor (7) Histone Methyltransferase (2) iGluR (4) Isotope-Labeled Compounds (39) mAChR (1) Monoamine Oxidase (1) Monoamine Transporter (2) mTOR (5) P-glycoprotein (4) P2X Receptor (4) PERK (5) Phosphodiesterase (PDE) (1) PI3K (5) Reference Standards (34) Sodium Channel (7) Thymidylate Synthase (1) Trk Receptor (5)
研究分野別:	Cancer (51) Cardiovascular Disease (4) Endocrinology (4) Infection (1) Inflammation/Immunology (5) Metabolic Disease (9) Neurological Disease (192)

標的別:

5-HT Receptor (52)

Serotonin Transporter (150)

Adrenergic Receptor (35)

Akt (5)

Antifolate (1)

Apoptosis (5)

Autophagy (16)

Calcium Channel (2)

Cholinesterase (ChE) (1)

Cytochrome P450 (2)

Dopamine Receptor (8)

Dopamine Transporter (17)

Drug Intermediate (1)

Drug Metabolite (13)

G Protein-coupled Receptor Kinase (GRK) (5)

GlyT (1)

Histamine Receptor (7)

Histone Methyltransferase (2)

iGluR (4)

Isotope-Labeled Compounds (39)

mAChR (1)

Monoamine Oxidase (1)

Monoamine Transporter (2)

mTOR (5)

P-glycoprotein (4)

P2X Receptor (4)

PERK (5)

Phosphodiesterase (PDE) (1)

PI3K (5)

Reference Standards (34)

Sodium Channel (7)

Thymidylate Synthase (1)

Trk Receptor (5)

研究分野別:

Cancer (51)

Cardiovascular Disease (4)

Endocrinology (4)

Infection (1)

Inflammation/Immunology (5)

Metabolic Disease (9)

Neurological Disease (192)

212

阻害剤およびアゴニスト

天然物

同位体標識化合物

Targets Recommended: 5-HT Receptor Serotonin Transporter

製品番号	製品名	Target	研究分野	構造式

HY-B0102A

Fluoxetine hydrochloride Maximum Cited Publications 40 Publications Verification LY 110140	Serotonin Transporter Autophagy	Neurological Disease Cancer
Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective **serotonin reuptake** inhibitor.

HY-B0102

Fluoxetine Maximum Cited Publications 40 Publications Verification LY-110140 free base	Serotonin Transporter Autophagy	Neurological Disease
Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-B0176A

Sertraline hydrochloride 15+ Cited Publications	Serotonin Transporter	Neurological Disease Cancer
Sertraline hydrochloride is an antidepressant of the selective **serotonin reuptake** inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive .

HY-122272

Paroxetine 15+ Cited Publications BRL29060	Serotonin Transporter Adrenergic Receptor P2X Receptor Apoptosis	Neurological Disease Cancer
Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B0492

Paroxetine hydrochloride 15+ Cited Publications BRL29060 hydrochloride; BRL29060A	Autophagy Serotonin Transporter G Protein-coupled Receptor Kinase (GRK)	Neurological Disease Cancer
Paroxetine hydrochloride is a potent selective *serotonin-reuptake* inhibitor, commonly prescribed as an GRK2 inhibitor with IC₅₀ of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder .

HY-B0161A

Duloxetine hydrochloride 10+ Cited Publications (S)-Duloxetine hydrochloride; LY-248686 hydrochloride	Serotonin Transporter	Neurological Disease Cancer
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a **serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i** of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0196

Venlafaxine 5+ Cited Publications Wy 45030	Serotonin Transporter	Neurological Disease Cancer
Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-121203

Citalopram 5+ Cited Publications	Serotonin Transporter	Neurological Disease Cancer
Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active *selective serotonin* reuptake inhibitor (SSRI)**. Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-B0103

Fluvoxamine 10+ Cited Publications DU-23000	Serotonin Transporter	Neurological Disease
Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-B0161

Duloxetine 10+ Cited Publications LY248686	Serotonin Transporter	Neurological Disease Cancer
Duloxetine is a **serotonin-norepinephrine reuptake inhibitor with a K_i** of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0304A

Dapoxetine hydrochloride 1 Publications Verification LY-210448 hydrochloride	Serotonin Transporter	Neurological Disease
Dapoxetine (LY-210448) hydrochloride is an orally active and selective **serotonin reuptake inhibitor (SSRI**). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE) .

HY-B0103A

Fluvoxamine maleate 10+ Cited Publications DU-23000 maleate	Serotonin Transporter	Neurological Disease Cancer
Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-14472

Tesofensine NS-2330	Dopamine Transporter Serotonin Transporter	Metabolic Disease
Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC₅₀=6.5 nM), norepinephrine (NE;IC₅₀=1.7 nM), and serotonin (5-HT;IC₅₀=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-B0196A

Venlafaxine hydrochloride 5+ Cited Publications Wy 45030 hydrochloride	Serotonin Transporter	Neurological Disease Cancer
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B1287

Citalopram hydrobromide 5+ Cited Publications (±)-Citalopram hydrobromide; Lu 10-171	Serotonin Transporter Autophagy	Neurological Disease Cancer
Citalopram hydrobromide is a *selective serotonin* reuptake inhibitor (SSRI)*, with blood-brain barrier permeability. Citalopram hydrobromide inhibits 5-HT uptake* into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-U00096

Ansofaxine hydrochloride LY03005; LPM570065	5-HT Receptor Dopamine Receptor	Neurological Disease Inflammation/Immunology
Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits *serotonin, dopamine* and norepinephrine reuptake with IC₅₀ values of 723, 491 and 763 nM, respectively.

HY-B0492A

Paroxetine hydrochloride hemihydrate 10+ Cited Publications BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate	Autophagy Serotonin Transporter G Protein-coupled Receptor Kinase (GRK)	Neurological Disease
Paroxetine hydrochloride hemihydrate is a potent selective *serotonin-reuptake* inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC₅₀ of 14 μM.

HY-19907

Liafensine BMS-820836	Dopamine Transporter Monoamine Transporter Serotonin Transporter	Neurological Disease
Liafensine (BMS-820836) is an orally active, blood-brain barrier-permeable monoamine reuptake inhibitor, with an IC₅₀ of 5.67 nM against DAT, 1.08 nM against SERT, and 7.99 nM against NET. Liafensine binds to DAT to block dopamine reuptake. Liafensine binds to SERT to block serotonin reuptake. Liafensine binds to NET to block norepinephrine reuptake. Liafensine can be used in studies related to depression .

HY-W011235

Norfluoxetine hydrochloride	5-HT Receptor Calcium Channel Drug Metabolite	Cardiovascular Disease Neurological Disease
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity .

HY-12850A

Dasotraline hydrochloride SEP-225289 hydrochloride	Serotonin Transporter Dopamine Transporter	Neurological Disease
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and *serotonin* transporters with IC₅₀ values of 4, 6, and 11 nM, respectively.

HY-20696

Tetrahydro-β-carboline Tryptoline	5-HT Receptor	Metabolic Disease
Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive **serotonin reuptake inhibitor with an K_i** value of 6.1 µM .

HY-B0102B

(S)-Fluoxetine hydrochloride	Serotonin Transporter	Neurological Disease
(S)-Fluoxetine hydrochloride, an antidepressant, is **serotonin reuptake** inhibitor (SSRI) .

HY-B0196AS1

Venlafaxine-d6 hydrochloride Wy 45030-d6 hydrochloride	Serotonin Transporter	Neurological Disease
Venlafaxine-d₆ (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-14794

Dextromilnacipran (1R,2S)-Milnacipran; F2696	Serotonin Transporter Adrenergic Receptor	Neurological Disease Metabolic Disease
Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active *Serotonin* (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia .

HY-B0196R

Venlafaxine (Standard) Wy 45030 (Standard)	Serotonin Transporter Reference Standards	Neurological Disease Cancer
Venlafaxine (Standard) is the analytical standard of Venlafaxine. This product is intended for research and analytical applications. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-110019

Indatraline hydrochloride Lu 19-005	Serotonin Transporter Dopamine Transporter	Neurological Disease
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, *serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy* while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .

HY-B0196S

Venlafaxine-d6	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Venlafaxine-d₆ is the deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-122272R

Paroxetine (Standard) BRL29060 (Standard)	Serotonin Transporter Adrenergic Receptor P2X Receptor Apoptosis Reference Standards	Neurological Disease Cancer
Paroxetine (Standard) is the analytical standard of Paroxetine. This product is intended for research and analytical applications. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B0304

Dapoxetine (S)-(+)-Dapoxetine; LY-210448	Serotonin Transporter	Neurological Disease
Dapoxetine (LY-210448) is an orally active and selective **serotonin reuptake inhibitor (SSRI**). Dapoxetine can be used for the research of premature ejaculation (PE) .

HY-18332A

Amitifadine hydrochloride DOV-21947 hydrochloride; EB-1010 hydrochloride	Serotonin Transporter Dopamine Transporter	Infection Neurological Disease
Amitifadine (DOV-21947; EB-1010) hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

HY-117526

(-)-Mesembrine	Serotonin Transporter	Neurological Disease
(-)-Mesembrine is a serotonin transporter (SERT) inhibitor. (-)-Mesembrine inhibits serotonin reuptake. (-)-Mesembrine exerts anxiolytic, mood-enhancing and anti-addictive effects. (-)-Mesembrine is applicable to research on mild-to-moderate depression, anxiety disorders and stress-related conditions .

HY-14472R

Tesofensine (Standard) NS-2330 (Standard)	Dopamine Transporter Serotonin Transporter Reference Standards	Metabolic Disease
Tesofensine (Standard) is the analytical standard of Tesofensine. This product is intended for research and analytical applications. Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-18332C

DOV-216,303 Free Base	Serotonin Transporter Dopamine Transporter	Neurological Disease
DOV-216,303 (Free Base) is a potent triple *serotonin, norepinephrine, and dopamine reuptake* inhibitor, with IC₅₀ values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats .

HY-106956A

Lubazodone hydrochloride	Serotonin Transporter	Neurological Disease
Lubazodone hydrochloride is a selective serotonin reuptake inhibitor and can be used for study of depression .

HY-U00096A

Ansofaxine Toludesvenlafaxine; LY03005 free base; LPM570065 free base	Serotonin Transporter	Neurological Disease
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for the research of depression .

HY-G0005

Duloxetine metabolite Para-Naphthol Duloxetine Para-Naphthol duloxetine	Drug Metabolite	Neurological Disease
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).

HY-B0304AS

Dapoxetine-d7 hydrochloride LY-210448-d7 hydrochloride	Serotonin Transporter	Neurological Disease
Dapoxetine-d₇ (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI) .

HY-A0022

Azaphen Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride	Serotonin Transporter	Neurological Disease
Azaphen (Pipofezin) is an orally active *serotonin* reuptake inhibitor. Azaphen potentiates sympathomimetic compound effects. Azaphen can be used for the research of depressive states .

HY-148718

4-Chloro Trazodone hydrochloride	5-HT Receptor	Neurological Disease
4-Chloro Trazodone hydrochloride is an isomer of Trazodone hydrochloride (HY-B0478). Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders .

HY-B0773

Paroxetine mesylate BRL29060 mesylate	Serotonin Transporter Adrenergic Receptor	Neurological Disease
Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective *serotonin* reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-118835

Zimelidine	Serotonin Transporter	Neurological Disease
Zimelidine is an orally active selective *serotonin* reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance .

HY-121203S4

Citalopram-d3 hydrochloride	Serotonin Transporter Isotope-Labeled Compounds	Neurological Disease Cancer
Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active *selective serotonin* reuptake inhibitor (SSRI)**. Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-18332B

DOV-102,677	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC₅₀ = 129 nM; K_i = 222 nM), norepinephrine (NET) (IC₅₀ = 103 nM; K_i = 1030 nM), and serotonin (SERT) (IC₅₀ = 133 nM; K_i = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .

HY-172421

Cendifensine	Monoamine Transporter Serotonin Transporter Dopamine Transporter	Neurological Disease
Cendifensine is the inhibitor for monoamine reuptake that inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) .

HY-121203S

Citalopram-d4 hydrobromide	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Citalopram-d₄ (hydrobromide) is the deuterium labeled Citalopram hydrobromide. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) .

HY-167894

DA-8031	Serotonin Transporter	Neurological Disease
DA-8031 is a selective and orally active **serotonin reuptake** inhibitor. DA-8031 can be used for the research of premature ejaculation (PE) .

HY-W344115

Bicifadine	5-HT Receptor Dopamine Transporter Adrenergic Receptor	Neurological Disease
Bicifadine is an orally active *serotonin/norepinephrine/dopamine* triple reuptake inhibitor. Bicifadine is an effective antinociceptive in several models of acute, persistent, and chronic pain .

HY-A0022A

Azaphen dihydrochloride monohydrate 1 Publications Verification Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate	Serotonin Transporter	Neurological Disease
Azaphen (Pipofezin) dihydrochloride monohydrate is an orally active *serotonin* reuptake inhibitor. Azaphen dihydrochloride monohydrate potentiates sympathomimetic compound effects. Azaphen dihydrochloride monohydrate can be used for the research of depressive states .

HY-B0161E

(±)-Duloxetine hydrochloride (Rac)-Duloxetine hydrochloride	Serotonin Transporter	Neurological Disease
(±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research .

HY-B0196B

(S)-Venlafaxine	Serotonin Transporter	Cancer
(S)-Venlafaxine is the (S)-configuration of Venlafaxine. Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant agent .

製品番号	製品名	Category	Target	構造式

HY-14258

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	天然物 Endogenous metabolite Source Classification	Serotonin Transporter
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective **serotonin reuptake inhibitor (SSRI) with a K_i** of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-117526

(-)-Mesembrine	Alkaloids Structural Classification Aizoaceae Mesembryanthemum tortuosum Plants Indole Alkaloids Source Classification	Serotonin Transporter
(-)-Mesembrine is a serotonin transporter (SERT) inhibitor. (-)-Mesembrine inhibits serotonin reuptake. (-)-Mesembrine exerts anxiolytic, mood-enhancing and anti-addictive effects. (-)-Mesembrine is applicable to research on mild-to-moderate depression, anxiety disorders and stress-related conditions .

HY-A0022

Azaphen Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride	Structural Classification 天然物 Animals Source Classification	Serotonin Transporter
Azaphen (Pipofezin) is an orally active *serotonin* reuptake inhibitor. Azaphen potentiates sympathomimetic compound effects. Azaphen can be used for the research of depressive states .

HY-N0913R

Manninotriose (Standard)	Structural Classification Polysaccharides Microorganisms other families Plants Saccharides Source Classification	Reference Standards Antifolate Thymidylate Synthase
Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

HY-14258R

Escitalopram (Standard) (S)-Citalopram (Standard); (S)-(+)-Citalopram (Standard)	Structural Classification 天然物 Endogenous metabolite Source Classification	Serotonin Transporter Reference Standards
Escitalopram (Standard) is the analytical standard of Escitalopram. This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-N17247

Mesembranol (-)-Mesembranol	Structural Classification Alkaloids other families Other Alkaloids Plants Source Classification	Phosphodiesterase (PDE)
Mesembranol ((-)-Mesembranol) is a mesembrine-type alkaloid and **serotonin reuptake** inhibitor. Mesembranol can be found in Sceletium tortuosum and exhibits phosphodiesterase 4 (PDE4) inhibition. Mesembranol contributes to the psychoactive properties of Sceletium tortuosum. Mesembranol can be used for the research of central nervous system-related conditions .

製品番号	製品名	構造式

HY-B0196AS1

Venlafaxine-d6 hydrochloride
Venlafaxine-d₆ (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0196S

Venlafaxine-d6
Venlafaxine-d₆ is the deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0176AS

rel-Sertraline-d3 hydrochloride
rel-Sertraline-d₃ (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive .

HY-B0161S

Duloxetine-d7
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0304AS

Dapoxetine-d7 hydrochloride
Dapoxetine-d₇ (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI) .

HY-B0492S1

Paroxetine-d4 hydrochloride
Paroxetine-d₄ (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC₅₀ of 14?μM. Paroxetine hydrochloride can be used for the research of depressive disorder .

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-121203S4

Citalopram-d3 hydrochloride
Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active *selective serotonin* reuptake inhibitor (SSRI)**. Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-121203S

Citalopram-d4 hydrobromide
Citalopram-d₄ (hydrobromide) is the deuterium labeled Citalopram hydrobromide. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) .

HY-14261S

Vilazodone-d8 1 Publications Verification
Vilazodone-d₈ is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.

HY-B0176AS1

(±)-cis-Sertraline-d3 hydrochloride
(±)-cis-Sertraline-d₃ (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive .

HY-B0196AS

Venlafaxine-d10 hydrochloride
Venlafaxine-d₁₀ (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine (Wy 45030) hydrochloride is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-14794S

Dextromilnacipran-d6
Dextromilnacipran-d₆ is the deuterium labeled Dextromilnacipran (HY-14794). Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active *Serotonin* (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia .

HY-14262S1

Vilazodone-d8 hydrochloride
Vilazodone-d₈ hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

HY-B0168S

Milnacipran-d10 hydrochloride

Milnacipran-d₁₀ (hydrochloride) is the deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (K_i values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-B0103AS1

Fluvoxamine-d4 maleate
Fluvoxamine-d₄ (maleate) is the deuterium labeled Fluvoxamine maleate. Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-B0304AS1

Dapoxetine-d6 hydrochloride
Dapoxetine-d6 (LY-210448-d6) hydrochloride is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)

HY-B0103AS2

Fluvoxamine-13C, d3 maleate
Fluvoxamine- ¹³C, d₃ maleate is ¹³C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-B0196S1

Venlafaxine-d6-1
Venlafaxine-d₆-1 is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0161AS

Duloxetine-d3 hydrochloride
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0304S

Dapoxetine-d6
Dapoxetine-d₆ is the deuterium labeled Dapoxetine . Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE) .

HY-B0161ES

(±)-Duloxetine-d3 hydrochloride
(±)-Duloxetine-d₃ (hydrochloride) is deuterium labeled (±)-Duloxetine (hydrochloride). (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research .

HY-B0102S

Fluoxetine-d6
Fluoxetine-d₆ (LY-110140 (free base)-d₆) is deuterium labeled Fluoxetine. Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-B0196S3

Venlafaxine-d10
Venlafaxine-d₁₀ (Wy 45030-d₁₀) is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0196S2

Venlafaxine-d4
Venlafaxine-d₄ (Wy 45030-d₄) is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0161S3

Duloxetine-d5 oxalate
Duloxetine-d₅ (oxalate) ((S)-Duloxetine-d₅ (oxalate)) is deuterium labeled Duloxetine. Duloxetine is a **serotonin-norepinephrine reuptake inhibitor with a K_i** of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0602S1

(S)-(+)-O-Desmethyl Venlafaxine-d6
(S)-(+)-O-Desmethyl Venlafaxine-d₆ is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine . Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class .

HY-B0602S

(R)-(-)-O-Desmethyl Venlafaxine-d6
(R)-(-)-O-Desmethyl Venlafaxine-d₆ is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine . Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class .

HY-122272S2

Paroxetine-d6-1
Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective *serotonin* reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-B0196S4

Venlafaxine-d9
Venlafaxine-d₉ (Wy 45030-d₉) is a deuterium labeled Venlafaxine (HY-B0196). Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0161AS1

Duloxetine-d7 hydrochloride
Duloxetine-d7 hydrochloride ((S)-Duloxetine-d7 hydrochloride) is the deuterium labeled Duloxetine hydrochloride (HY-B0161A). Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a **serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i** of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-W700149

N,O-Didesmethylvenlafaxine-d3
N,O-Didesmethylvenlafaxine-d₃ is the deuterium labeled N,O-Didesmethylvenlafaxine (HY-138818). N,O-Didesmethylvenlafaxine (NODVFX) is a metabolite of Venlafaxine (VFX; HY-B0196). Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor .

HY-111124

Paroxetine-d2

Paroxetine-d₂ (CTP 347) is a deuterium labeled Paroxetine (HY-122272). Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B1287S

Citalopram-d3 hydrobromide

Citalopram-d₃ ((±)-Citalopram-d₃) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-B0168AS

Milnacipran-d5 hydrochloride

Milnacipran-d₅ hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (K_i values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .

HY-110289S1

(R)-Citalopram-d4 oxalate
(R)-Citalopram-d₄ (oxalate) is deuterium labeled (R)-Citalopram Oxalate. (R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a **serotonin reuptake** inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression .

HY-14794AS

Levomilnacipran-d10 hydrochloride

Levomilnacipran-d₁₀ ((1S,2R)-Milnacipran-d₁₀) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

HY-B0168BS

Levomilnacipran-d5 hydrochloride

Levomilnacipran-d5 ((1S,2R)-Milnacipran-d5) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

HY-107370S

Atomoxetine-d7

Atomoxetine-d₇ (Tomoxetine-d₇) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-107370S1

Atomoxetine-d5

Atomoxetine-d₅ (Tomoxetine-d₅) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-118835S

Zimeldine-d6

Zimeldine-d₆ is the deuterium labeled Zimeldine (HY-118835) . Zimelidine is an orally active selective serotonin reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance .

HY-B0102SA

Fluoxetine-d6 oxalate
Fluoxetine-d₆ oxalate (LY-110140-d₆ oxalate) is the deuterium labeled Fluoxetine oxalate. Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-170021

Dapoxetine-d7
Dapoxetine-d₇ (LY-210448-d₇) is the deuterium labeled Dapoxetine (HY-B0304). Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE) .

HY-17385S1

Atomoxetine-d7 hydrochloride

Atomoxetine-d₇ hydrochloride (Tomoxetine-d₇ hydrochloride) is the deuterium labeled Atomoxetine hydrochloride (HY-17385). Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .

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