D-473
D-473 is an orally active, blood-brain barrier-penetrant reuptake inhibitor with a preference for serotonin. D-473 inhibits the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET), significantly elevating the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits clear antidepressant-like activity without inducing motor activation. D-473 is widely used in research related to major depressive disorder.
For research use only. We do not sell to patients.
- CAS No.: 1632000-05-5
- Formula: C26H27F2NO3
- Molecular Weight:439.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
D-473 (25 mg/kg; p.o.; single dose) does not significantly alter locomotor activity in rats[1].
D-473 (10 mg/kg; i.p.; single dose) significantly elevates extracellular dopamine, serotonin, and norepinephrine in the rat mPFC and DLS, while reducing levels of dopamine metabolites in these regions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rat with major depressive disorder (male, 200-225 g)[1]
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Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg
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Administration:p.o.; single dose; 1 hour prior to 5-minute swim test
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Result:Produced no significant reduction in immobility time at 5 mg/kg.
Reduced immobility time significantly compared to vehicle at 10 mg/kg.
Reduced immobility time significantly compared to vehicle at 25 mg/kg.
Reduced immobility time significantly compared to vehicle at 50 mg/kg.
Chemical Information
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CAS No. 1632000-05-5
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Molecular Weight 439.49
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Formula C26H27F2NO3
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SMILES
O[C@@H]([C@@H](CO1)NCC2=CC=C(C=C2)OC)C[C@H]1C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-473 Related Classifications
HY-182247 Related Classifications
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