Dapoxetine hydrochloride
Based on 1 publication(s) in Google Scholar
Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE).
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 129938-20-1
- Formula: C21H24ClNO
- Molecular Weight:341.87
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Dapoxetine hydrochloride
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Biological Activity
Target: serotonin reuptake[1]
Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine dopamine.Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar rats[2]
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Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:Oral gavage; 1-10 mg/kg; once daily
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Result:Reverted most of the changes made by testosterone injection
Chemical Information
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CAS No. 129938-20-1
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Appearance Solid
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Molecular Weight 341.87
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Formula C21H24ClNO
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Color White to off-white
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SMILES
CN(C)[C@H](C1=CC=CC=C1)CCOC2=C3C(C=CC=C3)=CC=C2.Cl
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Synonyms
LY-210448 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Molecules
Dapoxetine, a Selective Serotonin Reuptake Inhibitor, Suppresses Zika Virus Infection In Vitro. [Abstract]2023 Dec 17;28(24):8142. PMID: 38138628
Solvent & Solubility
H2O : 100 mg/mL (292.51 mM; Need ultrasonic)
DMSO : ≥ 32 mg/mL (93.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89. [Content Brief]
[2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.9251 mL | 14.6254 mL | 29.2509 mL | 73.1272 mL |
| 5 mM | 0.5850 mL | 2.9251 mL | 5.8502 mL | 14.6254 mL | |
| 10 mM | 0.2925 mL | 1.4625 mL | 2.9251 mL | 7.3127 mL | |
| 15 mM | 0.1950 mL | 0.9750 mL | 1.9501 mL | 4.8751 mL | |
| 20 mM | 0.1463 mL | 0.7313 mL | 1.4625 mL | 3.6564 mL | |
| 25 mM | 0.1170 mL | 0.5850 mL | 1.1700 mL | 2.9251 mL | |
| 30 mM | 0.0975 mL | 0.4875 mL | 0.9750 mL | 2.4376 mL | |
| 40 mM | 0.0731 mL | 0.3656 mL | 0.7313 mL | 1.8282 mL | |
| 50 mM | 0.0585 mL | 0.2925 mL | 0.5850 mL | 1.4625 mL | |
| 60 mM | 0.0488 mL | 0.2438 mL | 0.4875 mL | 1.2188 mL | |
| 80 mM | 0.0366 mL | 0.1828 mL | 0.3656 mL | 0.9141 mL | |
| H2O | 100 mM | 0.0293 mL | 0.1463 mL | 0.2925 mL | 0.7313 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dapoxetine hydrochloride Related Classifications
HY-B0304A Related Classifications
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