1. Neuronal Signaling
  2. Serotonin Transporter
  3. Dapoxetine hydrochloride

Dapoxetine hydrochloride (Synonyms: LY-210448 hydrochloride)

Cat. No.: HY-B0304A Purity: 99.93%
Handling Instructions

Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE).

For research use only. We do not sell to patients.

Dapoxetine hydrochloride Chemical Structure

Dapoxetine hydrochloride Chemical Structure

CAS No. : 129938-20-1

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Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 210 In-stock
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Description

Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE)[1].

IC50 & Target

Target: serotonin reuptake[1]

In Vitro

Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine.
Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Oral gavage; 1-10 mg/kg; once daily
Result: Reverted most of the changes made by testosterone injection
Clinical Trial
Molecular Weight

341.87

Formula

C₂₁H₂₄ClNO

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (93.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9251 mL 14.6254 mL 29.2509 mL
5 mM 0.5850 mL 2.9251 mL 5.8502 mL
10 mM 0.2925 mL 1.4625 mL 2.9251 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.93%

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Dapoxetine hydrochloride
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