1. Neuronal Signaling
  2. Serotonin Transporter
  3. Dapoxetine

Dapoxetine (Synonyms: (S)-(+)-Dapoxetine; LY-210448)

Cat. No.: HY-B0304
Handling Instructions

Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE).

For research use only. We do not sell to patients.

Dapoxetine Chemical Structure

Dapoxetine Chemical Structure

CAS No. : 119356-77-3

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Description

Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].

In Vitro

Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine.
Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Oral gavage; 1-10 mg/kg; once daily
Result: Reverted most of the changes made by testosterone injection.
Molecular Weight

305.41

Formula

C21H23NO

CAS No.
SMILES

CN(C)[[email protected]](C1=CC=CC=C1)CCOC2=CC=CC3=C2C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Dapoxetine
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HY-B0304
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