2. Neuronal Signaling
  3. Serotonin Transporter
  4. Dapoxetine

Dapoxetine  (Synonyms: (S)-(+)-Dapoxetine; LY-210448)

Cat. No.: HY-B0304
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Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Dapoxetine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Dapoxetine Chemical Structure

Dapoxetine Chemical Structure

CAS No. : 119356-77-3

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Dapoxetine Related Antibodies

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1 Publications Citing Use of MCE Dapoxetine

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Description

Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].

In Vitro

Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine.
Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dapoxetine Related Antibodies
In Vivo

Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Oral gavage; 1-10 mg/kg; once daily
Result: Reverted most of the changes made by testosterone injection.
Clinical Trial
Molecular Weight

305.41

Formula

C21H23NO
CAS No.
SMILES

CN(C)[C@H](C1=CC=CC=C1)CCOC2=CC=CC3=C2C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dapoxetine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dapoxetine119356-77-3(S)-(+)-Dapoxetine LY-210448LY210448LY 210448LY-210448Serotonin Transporter5-HTTSERTSLC6A4Premature ejaculationPEsexual disorderBenignProstate HyperplasiaBPHserotonin reuptakeInhibitorinhibitorinhibit

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