2. Neuronal Signaling
  3. Serotonin Transporter
  4. Dapoxetine-d7 hydrochloride

Dapoxetine-d7 hydrochloride  (Synonyms: LY-210448-d7 (hydrochloride))

Cat. No.: HY-B0304AS Purity: 99.92%
COA Handling Instructions

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Dapoxetine-d7 (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)[1].

For research use only. We do not sell to patients.

Dapoxetine-d<sub>7</sub> hydrochloride Chemical Structure

Dapoxetine-d7 hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dapoxetine-d7 hydrochloride:

Dapoxetine-d7 hydrochloride Related Antibodies

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Description

Dapoxetine-d7 (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)[1].

Molecular Weight

348.92

Formula

C21H17D7ClNO
Appearance

Solid

Color

White to off-white

SMILES

CN(C)[C@H](C1=CC=CC=C1)CCOC2=C3C(C([2H])=C([2H])C([2H])=C3[2H])=C([2H])C([2H])=C2[2H].Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (716.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (143.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8660 mL 14.3299 mL 28.6599 mL
5 mM 0.5732 mL 2.8660 mL 5.7320 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.96 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.96 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.8660 mL 14.3299 mL 28.6599 mL 71.6497 mL
5 mM 0.5732 mL 2.8660 mL 5.7320 mL 14.3299 mL
10 mM 0.2866 mL 1.4330 mL 2.8660 mL 7.1650 mL
15 mM 0.1911 mL 0.9553 mL 1.9107 mL 4.7766 mL
20 mM 0.1433 mL 0.7165 mL 1.4330 mL 3.5825 mL
25 mM 0.1146 mL 0.5732 mL 1.1464 mL 2.8660 mL
30 mM 0.0955 mL 0.4777 mL 0.9553 mL 2.3883 mL
40 mM 0.0716 mL 0.3582 mL 0.7165 mL 1.7912 mL
50 mM 0.0573 mL 0.2866 mL 0.5732 mL 1.4330 mL
60 mM 0.0478 mL 0.2388 mL 0.4777 mL 1.1942 mL
80 mM 0.0358 mL 0.1791 mL 0.3582 mL 0.8956 mL
100 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7165 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dapoxetine-d7 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dapoxetine-d7LY-210448-d7Serotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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