Fluoxetine oxalate
Based on 34 publication(s) in Google Scholar
Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
For research use only. We do not sell to patients.
- CAS No.: 114414-02-7
- Formula: C19H20F3NO5
- Molecular Weight:399.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Fluoxetine oxalate
More- Nat Med. 2019 Sep;25(9):1428-1441. [Abstract]
- Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
- Nat Commun. 2026 Jun 16. [Abstract]
- Adv Sci (Weinh). 2025 Jun 10:e01981. [Abstract]
- J Transl Med. 2024 Aug 22;22(1):785. [Abstract]
- Mol Med. 2026 Jun 13. [Abstract]
- Cell Rep. 2021 Nov 2;37(5):109957. [Abstract]
- Cell Prolif. 2021 Jan;54(1):e12953. [Abstract]
- Brain Behav Immun. 2026 Jan 26:134:106471. [Abstract]
- Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]
- J Med Chem. 2026 Jun 11;69(11):13618-13634. [Abstract]
- Biochem Pharmacol. 2023 Nov:217:115846. [Abstract]
- Foods. 2026 Jun 21;15(12):2237. [Abstract]
- Eur J Pharmacol. 2026 Mar 28:1019:178713. [Abstract]
- Eur J Pharmacol. 2025 Dec 15:1009:178391. [Abstract]
- Eur J Pharmacol. 2019 Jan 15:843:260-267. [Abstract]
- Biomedicines. 2023 Apr 26;11(5):1279. [Abstract]
- Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]
- Virol J. 2024 Aug 8;21(1):181. [Abstract]
- J Psychiatr Res. 2023 Oct 19:168:91-99. [Abstract]
- Reprod Toxicol. 2025 Jan 16:108840. [Abstract]
- Chem Biodivers. 2025 Sep 24:e00918. [Abstract]
- J Clin Psychopharmacol. 2021 Sep-Oct;41(5):525-533. [Abstract]
- Behav Brain Res. 2017 Jan 15:317:62-70. [Abstract]
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Behav Pharmacol. 2025 Apr 1;36(2-3):127-136. [Abstract]
- Behav Pharmacol. 2024 Jun 1;35(4):227-238. [Abstract]
- Behav Pharmacol. 2021 Feb 1;32(1):62-72. [Abstract]
- bioRxiv. 2026 May 29.
- Orebro University. 2024.
- Research Square Preprint. 2024 Dec 16.
- Research Square Preprint. 2023 Jun 29.
- Research Square Preprint. 2023 Jun 16.
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
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In Vivo Imaging
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In Vivo Efficacy Study
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IHC
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WB
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WB
Biological Activity
Chemical Information
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CAS No. 114414-02-7
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Molecular Weight 399.36
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Formula C19H20F3NO5
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SMILES
O=C(C(O)=O)O.FC(F)(C1=CC=C(C=C1)OC(CCNC)C2=CC=CC=C2)F
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Synonyms
LY-110140 oxalate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (34)
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Journal Impact Factor
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Most Recent
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Nat Med
2019 Sep;25(9):1428-1441. PMID: 31501614 -
Cell Metab
Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. [Abstract]2025 Dec 17:S1550-4131(25)00495-4. PMID: 41412121
Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
Ovarian cancer ID8 syngeneic model testing fluoxetine effect, Fluoxetine treatment (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest), Cisplatin (5 mg/kg, twice/week, intraperitoneal injection in indicated time windows). The figure shows representative bioluminescence imaging results.
Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
Fluoxetine (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest). Ovarian cancer PDX #1795 mouse model treated with PARPi (Olaparib) alone or with a combination of Fluoxetine.
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Nat Commun
Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice. [Abstract]2026 Jun 16. PMID: 42303982 -
Adv Sci (Weinh)
The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress. [Abstract]2025 Jun 10:e01981. PMID: 40492401 -
J Transl Med
ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation. [Abstract]2024 Aug 22;22(1):785. PMID: 39175013 -
Mol Med
The role of Dymeclin in chronic unpredictable mild stress-induced depression: maintaining the Golgi apparatus structure and regulating NLRP3 inflammasome activation. [Abstract]2026 Jun 13. PMID: 42288765 -
Cell Rep
2021 Nov 2;37(5):109957. PMID: 34731610 -
Cell Prolif
Direct inhibitory effect on viral entry of influenza A and SARS-CoV-2 viruses by azithromycin. [Abstract]2021 Jan;54(1):e12953. PMID: 33211371 -
Brain Behav Immun
Depression-related chronic stress promotes ovarian cancer progression via metabolic dysfunction and IRF1-mediated immune suppression. [Abstract]2026 Jan 26:134:106471. PMID: 41605304 -
Brain Behav Immun
Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes. [Abstract]2021 Jul:95:142-153. PMID: 33737174
Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]
Fluoxetine (20 mg/kg; ip). Representative images of DCX positive cells in the DG of hippocampus in different group.
Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]
Fluoxetine (20 mg/kg; ip). Representative immunoblots of DCX and NeuN expression levels in different groups.
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J Med Chem
Development of Novel Estradiol-Indole Hybrids Targeting SERT and ERβ as Potential Antidepressants. [Abstract]2026 Jun 11;69(11):13618-13634. PMID: 42154662 -
Biochem Pharmacol
Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms. [Abstract]2023 Nov:217:115846. PMID: 37804870 -
Foods
Fermented Dendrobium officinale Ameliorates Sleep Deprivation-Induced Depressive-like Behaviors by Attenuating Neuroinflammation and Restoring 5-HT Synthesis via the Gut-Brain Axis. [Abstract]2026 Jun 21;15(12):2237. PMID: 42354205 -
Eur J Pharmacol
Chronic co-treatment with geniposide and shanzhiside methyl ester elicits antidepressant effects via PACAP signaling in stressed male mice. [Abstract]2026 Mar 28:1019:178713. PMID: 41794274 -
Eur J Pharmacol
Gypenoside XVII regulates apoptosis and fear extinction deficits mediated by post-traumatic stress disorder through the PERK/CHOP signaling pathway. [Abstract]2025 Dec 15:1009:178391. PMID: 41276105 -
Eur J Pharmacol
2019 Jan 15:843:260-267. PMID: 30502341 -
Biomedicines
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation. [Abstract]2023 Apr 26;11(5):1279. PMID: 37238950 -
Prog Neuropsychopharmacol Biol Psychiatry
2017 Jun 15;79(Pt B):258-267. PMID: 28625859
Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]
Representative images showing the restoration effect of harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg; ip) was used as a positive control, and all data were shown as mean ± SEM.
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Virol J
2024 Aug 8;21(1):181. PMID: 39118175 -
J Psychiatr Res
2023 Oct 19:168:91-99. PMID: 39492237 -
Reprod Toxicol
Long-term Oral Fluoxetine Leads to Reduced Male Reproductive Function in Mice and Gradual Recovery After Discontinuation. [Abstract]2025 Jan 16:108840. PMID: 39826770 -
Chem Biodivers
New 2,3-Methylenedioxy-naphthalene Derivatives With Neuroprotective Activity From the Roots of Ephedra sinica Stapf. [Abstract]2025 Sep 24:e00918. PMID: 40991575 -
J Clin Psychopharmacol
Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People. [Abstract]2021 Sep-Oct;41(5):525-533. PMID: 34121064 -
Behav Brain Res
Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?. [Abstract]2017 Jan 15:317:62-70. PMID: 27633560 -
Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
Behav Pharmacol
Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. [Abstract]2025 Apr 1;36(2-3):127-136. PMID: 39611623 -
Behav Pharmacol
2024 Jun 1;35(4):227-238. PMID: 38651981 -
Behav Pharmacol
Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. [Abstract]2021 Feb 1;32(1):62-72. PMID: 33416256 -
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Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Purity & Documentation
References
[1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [Content Brief]
[2]. Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? Behav Brain Res. 2017 Jan 15;317:62-70. [Content Brief]
[3]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [Content Brief]
[4]. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [Content Brief]
[5]. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [Content Brief]
[6]. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [Content Brief]
Calculators
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