1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. Metapramine

Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel.

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Metapramine Chemical Structure

Metapramine Chemical Structure

CAS No. : 21730-16-5

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Description

Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1][2][3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].

IC50 & Target

NMDA receptor complex channel[4]

In Vivo

Metapramine (19560 RP) (0-20 mg/kg; i.p.) shows analgesic effects in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice[5]
Dosage: 0-20 mg/kg
Administration: Intraperitoneal injection
Result: Increased jump latency, threshold voltage, reduction in writhes, and tail flick latency in a dose-dependent manner.
Molecular Weight

238.33

Formula

C16H18N2

CAS No.
SMILES

CNC1C2=CC=CC=C2N(C)C3=C(C=CC=C3)C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Metapramine Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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