21730-16-5
21730-16-5
Chemical Structure
Metapramine
Synonym(s): 19560 RP
- CAS No.: 21730-16-5
- Formula:C16H18N2
- Molecular Weight:238.33
IUPAC Name: N,5-dimethyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-amine
InChIKey: YXVZOBVWVRFPTE-UHFFFAOYSA-N
SMILES: CNC1C2=CC=CC=C2N(C)C3=C(C=CC=C3)C1
Biological Activity: Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1][2][3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].
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Metapramine | Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel. | |||||||||||||||||||||
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References
- [1]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23. [Content Brief]
- [2]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23.
- [3]. H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8. [Content Brief]
- [4]. J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70. [Content Brief]
