BuChE-IN-22
BuChE-IN-22 is a pseudo-irreversible butyrylcholinesterase (BuChE) inhibitor, with IC50 values of 4 nM and 157 nM against hBuChE and hAChE, respectively. It also acts as a prodrug of 7-hydroxysertraline. BuChE-IN-22 releases 7-hydroxysertraline during BuChE inhibition. BuChE-IN-22 completely reverses Aβ25-35-induced short-term and long-term memory impairments in a mouse model of Alzheimer's disease. BuChE-IN-22 can be used in research related to Alzheimer's disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C23H26Cl2N2O2
- Peso molecular:433.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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hBCHE 4 nM (IC50) |
hAChE 157 nM (IC50) |
BuChE-IN-22 (Compound 8e) (255 μM; 48 h) remains stable in the absence of hBuChE, but is completely metabolized by hBuChE within 48 h, releasing 85% of the serotonin reuptake inhibitor HO-Sert[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (male, 6 weeks old, 30-35 g, intracerebroventricular injection of 9 nmol oligomeric Aβ25-35 peptide)[1]
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Dosage:0.3 mg/kg; 1 mg/kg (long-term non-spatial memory); 3 mg/kg (spatial working memory)
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Administration:i.p.; daily; 7 days (starting 20 minutes post-Aβ25-35 injection)
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Result:Completely prevented Aβ25-35-induced deficits in spontaneous alternation (spatial working memory) at 3 mg/kg.
Completely prevented Aβ25-35-induced deficits in passive avoidance retention latency (long-term non-spatial memory) at 1 mg/kg.
Chemical Information
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Peso molecular 433.37
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Fòrmula C23H26Cl2N2O2
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SMILES
CN[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=C(OC(N4CCCCC4)=O)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BuChE-IN-22 Related Classifications
HY-181865 Related Classifications
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