1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Ansofaxine hydrochloride

Ansofaxine hydrochloride (Synonyms: LY03005; LPM570065)

Cat. No.: HY-U00096 Purity: 99.85%
Handling Instructions

Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.

For research use only. We do not sell to patients.

Ansofaxine hydrochloride Chemical Structure

Ansofaxine hydrochloride Chemical Structure

CAS No. : 916918-84-8

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10 mM * 1 mL in DMSO USD 220 In-stock
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100 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.

IC50 & Target

serotonin

723 nM (IC50)

Dopamine Receptor

491 nM (IC50)

In Vivo

Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

417.97

Formula

C₂₄H₃₂ClNO₃

CAS No.

916918-84-8

SMILES

O=C(OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1)C3=CC=C(C)C=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (74.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3925 mL 11.9626 mL 23.9252 mL
5 mM 0.4785 mL 2.3925 mL 4.7850 mL
10 mM 0.2393 mL 1.1963 mL 2.3925 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats: Acute administration to examine the effects of ansofaxine and desvenlafaxine on extracellular 5-HT, DA and NE levels is performed by administering oral solutions, oral suspensions and intravenous solutions of ansofaxine and desvenlafaxine. An equal number of animals are used to examine the acute effects of ansofaxine and desvenlafaxine on extracellular 5-HT levels under the blockade of 5-HT1A receptors by pretreatment with WAY-100635. For the 14-day chronic administration, animals are randomly divided into three groups. Oral suspensions of ansofaxine, desvenlafaxine and vehicle are administered daily for 14 days. On the 14th day of chronic administration, the effects of ansofaxine and desvenlafaxine on the extracellular 5-HT, DA and NE levels are examined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

AnsofaxineLY03005 LPM570065LY 03005LY-03005LPM570065LPM 570065LPM-5700655-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product Name:
Ansofaxine hydrochloride
Cat. No.:
HY-U00096
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