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Cat. No.: HY-133171A

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(S)-Norfluoxetine

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(S)-Norfluoxetine, a S enantiomer of Norfluoxetine (HY-135556), is a selective serotonin reuptake inhibitor. (S)-Norfluoxetine can increase allopregnanolone levels and reduce aggression in socially isolated mice.

For research use only. We do not sell to patients.

CAS No.: 126924-38-7
Formula: C₁₆H₁₆F₃NO
Molecular Weight:295.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(S)-Norfluoxetine Chemical Structure

CAS No.: 126924-38-7

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Sample (0.1mg)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	2806 nM Compound: (S)-3	Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cells Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cells	[PMID: 19014888]
HEK293	IC₅₀	46 nM Compound: (S)-3	Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cells Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cells	[PMID: 19014888]
HEK293	IC₅₀	6488 nM Compound: (S)-3	Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cells Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cells	[PMID: 19014888]

Chemical Information

CAS No. 126924-38-7
Molecular Weight 295.30
Formula C₁₆H₁₆F₃NO
SMILES

FC(F)(F)C1=CC=C(O[C@@H](CCN)C2=CC=CC=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wong DT, et, al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology. 1993 Jun;8(4):337-44. [Content Brief]

[2]. Nelson M, et, al. S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology. 2011 Jun;60(7-8):1154-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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