(S)-Norfluoxetine
(S)-Norfluoxetine, a S enantiomer of Norfluoxetine (HY-135556), is a selective serotonin reuptake inhibitor. (S)-Norfluoxetine can increase allopregnanolone levels and reduce aggression in socially isolated mice.
For research use only. We do not sell to patients.
- CAS No.: 126924-38-7
- Formula: C16H16F3NO
- Molecular Weight:295.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
2806 nM
Compound: (S)-3
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Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cells
Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cells
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[PMID: 19014888] |
| HEK293 | IC50 |
46 nM
Compound: (S)-3
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Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cells
Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cells
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[PMID: 19014888] |
| HEK293 | IC50 |
6488 nM
Compound: (S)-3
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Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cells
Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cells
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[PMID: 19014888] |
Chemical Information
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CAS No. 126924-38-7
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Molecular Weight 295.30
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Formula C16H16F3NO
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SMILES
FC(F)(F)C1=CC=C(O[C@@H](CCN)C2=CC=CC=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wong DT, et, al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology. 1993 Jun;8(4):337-44. [Content Brief]
[2]. Nelson M, et, al. S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology. 2011 Jun;60(7-8):1154-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-Norfluoxetine Related Classifications
HY-133171A Related Classifications
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