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Results for "

Nors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (7) Acetyl-CoA Carboxylase (2) Adrenergic Receptor (3) Akt (1) Amino Acid Decarboxylase (2) Anion Exchangers (1) Antibiotic (4) Apoptosis (6) Arginase (4) Aryl Hydrocarbon Receptor (4) Bacterial (10) Biochemical Assay Reagents (4) Cannabinoid Receptor (5) Carbonic Anhydrase (1) CCR (1) Cytochrome P450 (4) DNA Glycosylase (1) DNA/RNA Synthesis (1) Dopamine Receptor (4) Drug Derivative (7) Drug Intermediate (1) Drug Metabolite (6) EAAT (3) EBV (4) EGFR (1) Endogenous Metabolite (2) Endothelin Receptor (1) Environmental Pollutants (1) Ephrin Receptor (1) Epoxide Hydrolase (1) ERK (1) Exosomes (2) Fluorescent Dye (2) Fungal (2) FXR (2) GHSR (1) Glutaminase (2) GSK-3 (1) HIV (2) HSP (1) HSV (3) iGluR (1) Influenza Virus (2) Isotope-Labeled Compounds (11) Keap1-Nrf2 (2) Liposome (1) mAChR (2) MEK (1) mGluR (1) Mitophagy (1) Monoamine Oxidase (2) nAChR (1) NF-κB (1) NO Synthase (4) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (5) Parasite (4) PGE synthase (1) Phosphodiesterase (PDE) (3) Potassium Channel (4) PPAR (5) Progesterone Receptor (1) Prolyl Endopeptidase (PREP) (1) Proteasome (1) Ras (2) Reactive Oxygen Species (ROS) (1) Reference Standards (8) Ser/Thr Protease (2) Serotonin Transporter (1) Small Interfering RNA (siRNA) (1) Taste Receptor (1) TRP Channel (3) VD/VDR (2) VEGFR (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (13) Endocrinology (5) Infection (27) Inflammation/Immunology (15) Metabolic Disease (14) Neurological Disease (40)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

136

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108357

*6-Diazo-5-oxo-L-nor-Leucine* 10+ Cited Publications L-6-Diazo-5-oxonorleucine; DON	Glutaminase Bacterial Influenza Virus Antibiotic	Infection Cancer
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity .

HY-112885B

nor-NOHA monoacetate 5 Publications Verification Nω-Hydroxy-nor-L-arginine monoacetate	Arginase Apoptosis	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA monoacetate is a selective and reversible arginase inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-12646

Rhosin hydrochloride Maximum Cited Publications 40 Publications Verification	Ras Apoptosis	Cancer
Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis . Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

HY-112885A

nor-NOHA acetate 5 Publications Verification Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate is a selective and reversible Arginase inhibitor. nor-NOHA acetate induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism .

HY-100784

Dihydrokainic acid 1 Publications Verification	EAAT	Neurological Disease
Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory .

HY-112885C

nor-NOHA dihydrochloride 5 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible Arginase inhibitor. nor-NOHA dihydrochloride induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride improves liver ischemia-reperfusion injury. nor-NOHA dihydrochloride can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism .

HY-18832

AWL-II-38.3	Ephrin Receptor	Cancer
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf .

HY-12646A

Rhosin Maximum Cited Publications 40 Publications Verification	Ras Apoptosis	Cancer
Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis . Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

HY-12949

ML204 5+ Cited Publications	TRP Channel	Neurological Disease
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-N6641

Monascin 2 Publications Verification	Keap1-Nrf2 PPAR	Inflammation/Immunology Cancer
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .

HY-117040

nor-Binaltorphimine 5+ Cited Publications Norbinaltorphimine; NorBNI	Opioid Receptor	Neurological Disease
nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain .

HY-100903

Norbinaltorphimine dihydrochloride 5+ Cited Publications nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride	Opioid Receptor	Neurological Disease
Norbinaltorphimine dihydrochloride (nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride) is a selective, long-acting competitive antagonist of the κ-opioid receptor. Norbinaltorphimine dihydrochloride blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. Norbinaltorphimine dihydrochloride suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. Norbinaltorphimine dihydrochloride is applicable to research related to neurological disorders such as pain .

HY-G0007

Omeprazole sulfone 2 Publications Verification Omeprazole sulphone	Drug Metabolite Cytochrome P450 Aryl Hydrocarbon Receptor	Inflammation/Immunology
Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-D1509

Phenazine ethosulfate	Fluorescent Dye	Others
Phenazine ethosulfate is a cationic dye (Ex=390 nm, Em=530 nm) and an electron acceptor that can be used in dye-linked enzyme assays. Phenazine ethosulfate is an intermediate for detecting nitric oxide reducatase (Nors) activity with the presence of ascorbic acid .

HY-112885

nor-NOHA Nω-Hydroxy-nor-L-arginine	Apoptosis Arginase	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-D1266

RB-OPD NO-red	Fluorescent Dye	Others
RB-OPD (NO-red) is a o-phenylenediamine (OPD)-locked rhodamine nitric oxide (NO) fluorescent probe with great sensitivity and selectivity (λex=550 nm, λem=590 nm) .

HY-153089

GSK3-IN-3 4 Publications Verification	GSK-3 Mitophagy	Neurological Disease
GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC₅₀ value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA .

HY-23789

2′-O-(2-Methoxyethyl)guanosine 2'-O-MOE-rG	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA .

HY-139899

S6821	Taste Receptor	Others
S6821 is a TAS2R8 antagonist with IC₅₀ value of 0.035 μM. S6821 is not found to be mutagenic or disruptive in vitro, nor is it found to induce micronucleus in bone marrow polychromatic erythrocytes in vivo .

HY-126326

SWE101	Epoxide Hydrolase	Metabolic Disease
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC₅₀s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH .

HY-W270810

NR4A agonist-1	Nuclear Hormone Receptor 4A/NR4A	Cancer
NR4A agonist-1, a fatty acid mimetic (FAM), is a potent NR4A agonist. NR4A agonist-1 exhibits high agonist potency on NR4A receptors Nurr1, Nur77, and NOR-1, with EC₅₀s of 0.09 μM, 0.04 μM, and 0.15 μM, respectively .

HY-W722043

MFZ 2-13 O-456	Drug Intermediate Dopamine Receptor	Neurological Disease
MFZ 2-13 (O-456) is an N-demethylated intermediate and N-nor-analogue of MFD 2-12. MFZ 2-13 inhibits dopamine uptake through the human dopamine receptor with an IC₅₀ of 1.4 nM .

HY-W742532

ETH-LAD N-Ethyl-nor-LSD	5-HT Receptor Dopamine Receptor	Neurological Disease
ETH-LAD (N-Ethyl-nor-LSD) is an activator for 5-HT2A receptor with K_i of 5.1 nM. ETH-LAD exhibits affinity for dopamine receptor D1 and dopamine receptor D2 with K_i of 22.1 nM and 4.4 nM. ETH-LAD acts as psychoactive substance in rat model .

HY-RS12110

ROBO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ROBO1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROBO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ROBO1 Human Pre-designed siRNA Set A ROBO1 Human Pre-designed siRNA Set A

HY-N15317

Phocaecholic acid β-Phocaecholic acid	Drug Metabolite	Metabolic Disease
Phocaecholic acid (β-Phocaecholic acid) is a bile acid found in duck bile. Phocaecholic acid can be excreted into bile and partially decarboxylated to nor-chenodeoxycholic acid in rats. Phocaecholic acid is promising for research of bile acid metabolism and related diseases .

HY-12949A

ML204 hydrochloride 5+ Cited Publications	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-N10851

*23-Nor-6-oxopristimerol*	Others	Others
23-Nor-6-oxopristimerol is a phenolic dinor-triterpene .

HY-179004

ONO-9517601 VU6022856	Potassium Channel	Neurological Disease
ONO-9517601 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC₅₀= 0.067 μM, TREK-2 IC₅₀= 0.23 μM). ONO-9517601 displays robust efficacy in an MK-801 (HY-15084B) challenge rat novel object recognition (NOR) paradigm. ONO-9517601 can be used for research on neurological and cognitive disorders .

HY-114861

Nor-6α-Oxycodol	Opioid Receptor	Neurological Disease
Nor-6α-Oxycodol is structurally similar to known opioids and is a metabolite of Oxycodone .

HY-108357R

*6-Diazo-5-oxo-L-nor-Leucine (Standard)* L-6-Diazo-5-oxonorleucine (Standard); DON (Standard)	Reference Standards Glutaminase Bacterial Influenza Virus Antibiotic	Infection Cancer
6-Diazo-5-oxo-L-nor-Leucine (Standard) is the analytical standard of 6-Diazo-5-oxo-L-nor-Leucine. This product is intended for research and analytical applications. 6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].

HY-B0132B

Norfloxacin (nicotinate) MK-0366 (nicotinate)	Bacterial Antibiotic	Infection
Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration .

HY-43711

Nor-benzetimide	mAChR	Neurological Disease
Nor-benzetimide is a major metabolite of Benzetimide. Benzetimide is a mAChR antagonist with anticholinergic activity .

HY-179005

ONO-7927846 VU6024391	Potassium Channel	Neurological Disease
ONO-7927846 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC₅₀= 0.11 μM, TREK-2 IC₅₀= 0.29 μM). ONO-7927846 displays robust efficacy in an MK-801 (HY-15084B) challenge rat novel object recognition (NOR) paradigm. ONO-7927846 can be used for research on neurological and cognitive disorders .

HY-131896

FR144420 NOR4	NO Synthase	Cardiovascular Disease
FR144420 (NOR4) is an orally active nitric oxide (NO)-releasing agent with vasodilatory and antiplatelet effects. FR144420 induces cGMP-mediated vasodilation and inhibits platelet aggregation. FR144420 is promising for research of cardiovascular diseases, particularly angina pectoris and coronary artery spasm .

HY-149812

AcrB-IN-4	Bacterial Parasite	Infection
Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model .

HY-176411

ONO-TR-772 VU6018042	Potassium Channel	Neurological Disease
ONO-TR-772 (VU6018042) is a selective TREK inhibitor (IC₅₀: 15 nM). ONO-TR-772 enhances recognition memory in the MK-801-stimulated NOR mouse model. ONO-TR-772 can be used in the study of diseases related to cognitive impairment .

HY-N8041

Mogroside III A2	HSV	Infection
Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1 .

HY-100784R

Dihydrokainic acid (Standard)	Reference Standards EAAT	Neurological Disease
Dihydrokainic acid (Standard) is the analytical standard of Dihydrokainic acid. This product is intended for research and analytical applications. Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects .

HY-155330

PZ-1922	5-HT Receptor Monoamine Oxidase	Neurological Disease
PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (K_i: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC₅₀: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test .

HY-155330A

PZ-1922 free base	5-HT Receptor Monoamine Oxidase	Neurological Disease
PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (K_i: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC₅₀: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test .

HY-172080

*(-)-7-Nor-7-carboxy cannabidiol*	Cannabinoid Receptor	Neurological Disease
(-)-7-Nor-7-carboxy cannabidiol is a phytocannabinoid metabolite. (-)-7-Nor-7-carboxy cannabidiol is a metabolite of Cannabidiol.

HY-157061S

*7-Nor-7-carboxycannabidiol-d10*	Isotope-Labeled Compounds	Others
7-Nor-7-carboxycannabidiol-d₁₀ is deuterium-labeled 7-Nor-7-carboxycannabidiol .

HY-170047A

*11-Nor-9(S)-carboxy-hexahydrocannabinol* 11-Nor-9α-carboxy-HHC	Cannabinoid Receptor	Neurological Disease
11-Nor-9(S)-carboxy-hexahydrocannabinol (11-Nor-9α-carboxy-HHC) is structurally similar to known phytocannabinoids .

HY-170047

*11-Nor-9(R)-carboxy-hexahydrocannabinol* 11-Nor-9β-carboxy-HHC	Cannabinoid Receptor	Neurological Disease
11-Nor-9(S)-carboxy-hexahydrocannabinol (11-Nor-9β-carboxy-HHC) is structurally similar to known phytocannabinoids .

HY-143542S

Nor neostigmine-d6	Isotope-Labeled Compounds	Others
Nor neostigmine-d₆ is the deuterium labeled Nor neostigmine .

HY-132435S

Nor Propranolol-d7 hydrochloride	Isotope-Labeled Compounds	Others
Nor Propranolol-d₇ hydrochloride is the deuterium labeled Nor Propranolol hydrochloride .

HY-131101R

Nor-Acetildenafil (Standard)	Reference Standards Phosphodiesterase (PDE)	Others
Nor-Acetildenafil (Standard) is the analytical standard of Nor-Acetildenafil. This product is intended for research and analytical applications. Nor-Acetildenafil is an Acetildenafil derivative. Acetildenafil is a synthetic agent which acts as a phosphodiesterase inhibitor .

HY-168793

*(±)-9-Nor-9β-hydroxy Hexahydrocannabinol*	Cannabinoid Receptor	Neurological Disease
(±)-9-Nor-9β-hydroxy Hexahydrocannabinol is structurally similar to known synthetic cannabinoids.

HY-143665S

Nor-W-18-d4 Desphenethyl-W-18-d₄	Isotope-Labeled Compounds	Others
Nor-W-18-d₄ is the deuterium labeled Nor-W-18 .

HY-146067

*β-Nor-lapachone*	Fungal Reactive Oxygen Species (ROS)	Infection
β-Nor-lapachone is a *Candida glabrata* antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity .

Cat. No.	Product Name	Type

HY-D1509

Phenazine ethosulfate	Fluorescent Dyes
Phenazine ethosulfate is a cationic dye (Ex=390 nm, Em=530 nm) and an electron acceptor that can be used in dye-linked enzyme assays. Phenazine ethosulfate is an intermediate for detecting nitric oxide reducatase (Nors) activity with the presence of ascorbic acid .

HY-D1266

RB-OPD NO-red	Fluorescent Dyes
RB-OPD (NO-red) is a o-phenylenediamine (OPD)-locked rhodamine nitric oxide (NO) fluorescent probe with great sensitivity and selectivity (λex=550 nm, λem=590 nm) .

HY-D2957

BG-Nor NorBG; SNAP-Nor	Fluorescent Dyes
BG-Nor (NorBG) is a Benzylguanine analogue containing Norbornene (HY-W013021). BG-Nor can be converted by cell surface SNAP tags. NorBG can be used for tetrazine-linked labeling of cells via the iEDDA reaction .

Cat. No.	Product Name	Type

HY-15435A

CHAPS hydrate

4 Publications Verification

Biochemical Assay Reagents

CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins .

HY-23789

2′-O-(2-Methoxyethyl)guanosine 2'-O-MOE-rG	Biochemical Assay Reagents
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA .

Cat. No.	Product Name	Target	Research Area

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-P4851

Adipokinetic hormone (Manduca sexta) Manse-AKH	Peptides	Others
Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) is a common peptide among various insects. Adipokinetic Hormone induces strong adipokinetic/hypertrehalosemic response. However Adipokinetic Hormone has no a glycogen-mobilizing function nor an adequate glycogen store in fat body for its effective utilization .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-30004

1-Aminocyclopropane-1-carboxylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .

HY-N6641

Monascin 2 Publications Verification	Natural Products Microorganisms other families Classification of Application Fields Pigments Plants Inflammation/Immunology Disease Research Fields Source Classification Food Research	Keap1-Nrf2 PPAR
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .

HY-N0468

Rebaudioside D 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Sweeteners Source Classification Food Research	FXR Acetyl-CoA Carboxylase
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-N7041

11-Oxomogroside IIa	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Source Classification	EBV HSV
11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. 11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

HY-30004R

1-Aminocyclopropane-1-carboxylic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
1-Aminocyclopropane-1-carboxylic acid (Standard) is the analytical standard of 1-Aminocyclopropane-1-carboxylic acid. This product is intended for research and analytical applications. 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity. .

HY-N15317

Phocaecholic acid β-Phocaecholic acid	Animals Ketones, Aldehydes, Acids Source Classification	Drug Metabolite
Phocaecholic acid (β-Phocaecholic acid) is a bile acid found in duck bile. Phocaecholic acid can be excreted into bile and partially decarboxylated to nor-chenodeoxycholic acid in rats. Phocaecholic acid is promising for research of bile acid metabolism and related diseases .

HY-N11009

11-Oxomogroside II A1	Triterpenes Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Source Classification	EBV
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

HY-145491

Resolvin D5	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	ERK NF-κB CCR
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .

HY-N10851

*23-Nor-6-oxopristimerol*	Kokoona zeylanica Thwaites Triterpenes Structural Classification Terpenoids Celastraceae Plants Source Classification	Others
23-Nor-6-oxopristimerol is a phenolic dinor-triterpene .

HY-N7040

11-Deoxymogroside IIE	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Source Classification	HSV
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. 11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor .

HY-N0468R

Rebaudioside D (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards Acetyl-CoA Carboxylase FXR
Rebaudioside D (Standard) is the analytical standard of Rebaudioside D. This product is intended for research and analytical applications. Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-N8041

Mogroside III A2	Infection Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Source Classification	HSV
Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1 .

HY-N1713

*29-Nor-20-oxolupeol*	Triterpenes Structural Classification Classification of Application Fields Terpenoids Labiatae Plants Inflammation/Immunology Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb. Source Classification	Others
29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC₅₀ of 44.21 µM .

HY-N15709

Nor-Rubrofusarin gentiobioside	Cassia tora (L.) Roxb. Structural Classification Leguminosae Ketones, Aldehydes, Acids Phenols Polyphenols Plants Source Classification	Bacterial
Nor-Rubrofusarin gentiobioside is a phenolic glycoside de-rubrofusarin that can be isolated from the seeds of Cassia tora. The same series of extracts of Nor-Rubrofusarin gentiobioside have antibacterial effects on Staphylococcus aureus strains .

HY-W670564A

*(4S)-10-Nor-calamenen-10-one*	Structural Classification Terpenoids Sesquiterpenes Plants Alpinia oxyphylla Miq. Source Classification Zingiberaceae	NO Synthase
(4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla .

HY-N2944

Blumenol B	Citrus × aurantium Natsudaidai Natural Products Plants Source Classification Salicaceae	Others
Blumenol B, a C₁₃ nor-isoprenoid, can be isolated from the leaves of Casearia sylvestris .

HY-N6641R

Monascin (Standard)	Structural Classification Natural Products Microorganisms other families Plants Source Classification	Reference Standards Keap1-Nrf2 PPAR
Monascin (Standard) is the analytical standard of Monascin. This product is intended for research and analytical applications. Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .

HY-N16998

*16-Nor-7,15-dioxodehydroabieticacid*	Structural Classification Pinaceae Ketones, Aldehydes, Acids Pityrogramma triangularis Plants Source Classification	Drug Derivative
16-Nor-7,15-dioxodehydroabieticacid is a natural diterpene.

HY-N9752

Mogroside II B	Structural Classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Steroids Source Classification	EBV
Mogroside II B is a cucurbitane-type glycoside with a sweet taste in water. Mogroside II B inhibits the activation of Epstein Barr virus early antigen (EBV-EA) induced by Phorbol 12-myristate 13-acetate (TPA) (HY-18739). Mogroside II B exerts weak inhibitory effects on the activation of the nitric oxide (NO) donor (NOR1) .

HY-N17638

7-Oxomogroside V	Structural Classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Steroids Source Classification	EBV NO Synthase
7-Oxomogroside V is a cucurbitane-type glycoside isolated from the fruits of Siraitia grosvenorii. 7-Oxomogroside V inhibits the activation of Epstein-Barr virus early antigen (EBV-EA) induced by TPA (HY-18739). 7-Oxomogroside V also exerts weak inhibitory effects on the activation of the nitric oxide donor NOR 1. 7-Oxomogroside V is applicable to tumor-related research .

HY-N1706

*26-Nor-8-oxo-alpha-onocerin*	Lycopodiaceae Tetracyclic Triterpenoids Terpenoids Plants Lycopodium clavatum L. Source Classification	Others
26-Nor-8-oxo-alpha-onocerin is a Triterpenoids product that can be isolated from the herbs of Lycopodium clavatum .

HY-N18223

(R)-Hydroxymiltirone	Structural Classification Natural Products Salvia argentea L. Labiatae Plants Source Classification	Drug Derivative
(R)-Hydroxymiltirone is a 20-nor-abietane diterpenoid found in the root of Salvia argentea, and is identified as 1R-hydroxymiltirone .

HY-N19293

Aquastatin C	Structural Classification Monophenols Microorganisms Phenols Source Classification	Bacterial
Aquastatin C is a glycoaromatic derivative that can be found in Sporothrix sp. FN611. Aquastatin C is a substance that neither regulates bacterial enzymes nor inhibits bacterial growth .

HY-N16905

Diosbulbin I	Structural Classification Other Monoterpenes Terpenoids Plants Dioscorea bulbifera Linn. Dioscoreaceae Source Classification	Others
Diosbulbin I is a furan-type nor-diterpenoid compound that can be naturally extracted from the tubers of Dioscorea bulbifera L. Dioscorea bulbifera L. is traditionally used to research thyroid diseases and tumors .

HY-N3318

Marsdenoside F	Apocynaceae Structural Classification Tetracyclic Triterpenoids Terpenoids Plants Source Classification	HIV
Marsdenoside F is a polyoxygenated pregnane glycoside isolated from the stems of Marsdenia tenacissima. Marsdenoside F showed no significant cytotoxicity against A549 and MCF-7 cell lines, nor did it exhibit significant anti-HIV activity .

HY-182569

FR 111142	Structural Classification Natural Products Microorganisms Source Classification	VEGFR
FR 111142 is an angiogenesis inhibitor (IC₅₀ = 18.4 μM) and has anti-inflammatory activity (IC₅₀ = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS (HY-D1056)-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer, inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-157061S

*7-Nor-7-carboxycannabidiol-d10*
7-Nor-7-carboxycannabidiol-d₁₀ is deuterium-labeled 7-Nor-7-carboxycannabidiol .

HY-143542S

Nor neostigmine-d6
Nor neostigmine-d₆ is the deuterium labeled Nor neostigmine .

HY-132435S

Nor Propranolol-d7 hydrochloride
Nor Propranolol-d₇ hydrochloride is the deuterium labeled Nor Propranolol hydrochloride .

HY-143665S

Nor-W-18-d4
Nor-W-18-d₄ is the deuterium labeled Nor-W-18 .

HY-W717545

Nor Mianserin (Major)-d6
Nor Mianserin (Major)-d₆ is the deuterium labeled 1,2,3,4,10,14b-Hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine (HY-W702070).

HY-G0007S

Omeprazole sulfone-d3

Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-G0007S1

Omeprazole sulfone-13C,d3

Omeprazole sulfone- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-W707161

4-Methyl-2-(1-piperidinyl)-quinoline-d10
4-Methyl-2-(1-piperidinyl)-quinoline-d₁₀ is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels .

HY-W759947

*24-Nor* ursodeoxycholic acid acyl-b-D-glucuronide-d5**
24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide is the deuterium labeled 24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide (HY-W759947) .

HY-131101S

Nor-Acetildenafil-d8
Nor-Acetildenafil-d₈ is the deuterium labeled Nor-Acetildenafil. Nor-Acetildenafil is an Acetildenafil derivative. Acetildenafil is a synthetic agent which acts as a phosphodiesterase inhibitor .

HY-132422S

Nor Lidocaine-d5 hydrochloride
Nor Lidocaine-d₅ (hydrochloride) is the deuterium labeled Nor Lidocaine hydrochloride .

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