2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR Potassium Channel
  4. SEN 78702

SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC50 of 6.13. SEN 78702 has an acceptable hERG inhibition (IC50: 15.8 μM). SEN 78702 induces memory enhancement.

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SEN 78702

SEN 78702 Chemical Structure

CAS No. : 1205530-63-7

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Description

SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC50 of 6.13. SEN 78702 has an acceptable hERG inhibition (IC50: 15.8 μM). SEN 78702 induces memory enhancement[1].

IC50 & Target

pEC50: 6.13 (α7 nAChR); IC50: 15.8 μM (hERG)[1]
Cellular Effect
Cell Line Type Value Description References
CHO IC50
15.8 μM
Compound: 12, SEN78702, WYE-308775
Inhibition of human ERG expressed in CHO cells
Inhibition of human ERG expressed in CHO cells
[PMID: 23083093]
GH4-C1 EC50
0.74 μM
Compound: 12, SEN78702, WYE-308775
Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR
Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR
[PMID: 23083093]
GH4-C1 EC50
10.7 μM
Compound: 12, SEN78702, WYE-308775
Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells by patch clamp assay
Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells by patch clamp assay
[PMID: 23083093]
Molecular Weight

331.39

Formula

C17H22FN5O
CAS No.
SMILES

O=C(NC1=CC(C2=CC(F)=CN=C2)=NN1)CCCN3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SEN 78702 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEN 787021205530-63-7SEN78702SEN-78702nAChRPotassium ChannelNicotinic acetylcholine receptorsKcsAmemory enhancementNORPPIInhibitorinhibitorinhibit

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