VU6024578
VU6024578 (BI02982816) is a selective, orally active positive allosteric modulator (PAM) for metabotropic glutamate receptor (mGluR1), that activates human mGluR1 and rat mGluR1 with EC50 of 54 nM and 46 nM. VU6024578 exhibits antipsychotic activity in rats amphetamine-induced hyperactivity models and MK-801 (HY-15084B)-induced novel object recognition (NOR) models. VU6024578 is blood brain barrier penetrable.
For research use only. We do not sell to patients.
- Formula: C20H18ClN5O2
- Molecular Weight:395.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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rat mGluR1 46 nM (EC50) |
Human mGluR1 54 nM (EC50) |
Chemical Information
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Molecular Weight 395.84
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Formula C20H18ClN5O2
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SMILES
O=C(C1=CC(C2=CC=CO2)=CC=C1Cl)NCC3=CC(C4=CC=NN4C)=NN3C
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Synonyms
BI02982816
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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