3100913-05-8
Chemical Structure
VU6024578
Synonym(s): BI02982816
- CAS No.: 3100913-05-8
- Formula:C20H18ClN5O2
- Molecular Weight:395.84
InChIKey: DRUXADDGGKWTSU-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=CC=CO2)=CC=C1Cl)NCC3=CC(C4=CC=NN4C)=NN3C
Biological Activity: VU6024578 (BI02982816) is a selective, orally active positive allosteric modulator (PAM) for metabotropic glutamate receptor (mGluR1), that activates human mGluR1 and rat mGluR1 with EC50 of 54 nM and 46 nM. VU6024578 exhibits antipsychotic activity in rats amphetamine-induced hyperactivity models and MK-801 (HY-15084B)-induced novel object recognition (NOR) models. VU6024578 is blood brain barrier penetrable[1].
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VU6024578 | VU6024578 (BI02982816) is a selective, orally active positive allosteric modulator (PAM) for metabotropic glutamate receptor (mGluR1), that activates human mGluR1 and rat mGluR1 with EC50 of 54 nM and 46 nM. VU6024578 exhibits antipsychotic activity in rats amphetamine-induced hyperactivity models and MK-801 (HY-15084B)-induced novel object recognition (NOR) models. VU6024578 is blood brain barrier penetrable. | |||||||||||||||||||||
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Keywords
