AL-LAD
AL-LAD is a 5-HT2A receptor ligand with rat Ki values of 8.1 nM and 3.4 nM. AL-LAD mediates behavioral responses characteristic of serotonergic psychedelics. AL-LAD induces the head-twitch response in male C57BL/6J mice in an inverted-U-shaped dose-dependent manner. AL-LAD exhibits LSD-like behavioral effects in male C57BL/6J mice.
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- CAS No.: 65527-61-9
- Formule: C22H27N3O
- Masse moléculaire:349.47
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[1]|
5-HT2A Receptor 8.1 nM (Ki) |
5-HT2A Receptor 3.4 nM (Ki) |
In Vitro
AL-LAD exhibits high affinity for 5-HT2A receptors in rat frontal cortex homogenates, with Ki values of 8.1 nM (vs. [3H]ketanserin) and 3.4 nM (vs. [125I]-R-DOI)[1].
AL-LAD binds to D1 and D2 dopaminergic receptors in rat tissue homogenates with K0.5 values of 189 nM and 12.3 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6−8 weeks old)[1]
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Dosage:25 µg/kg; 50 µg/kg; 100 µg/kg; 200 µg/kg; 400 µg/kg
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Administration:i.p.; single dose
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Result:Dose-dependently induced HTR with an inverted-U-shaped response; maximal response occurred at 200 μg/kg.
Chemical Information
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CAS No. 65527-61-9
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Masse moléculaire 349.47
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Formule C22H27N3O
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SMILES
[H][C@@]1(CC2=CNC3=CC=CC4=C23)C4=C[C@H](CN1CC=C)C(N(CC)CC)=O
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Synonyms
6-Allyl-6-nor-LSD
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AL-LAD Related Classifications
HY-W743888 Related Classifications
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