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Art. -Nr.: HY-W743888

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AL-LAD

Name: AL-LAD
Brand: MedChemExpress
SKU: HY-W743888
Price: 571.00 USD
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(Synonyms: 6-Allyl-6-nor-LSD)

AL-LAD is a 5-HT2A receptor ligand with rat K_i values of 8.1 nM and 3.4 nM. AL-LAD mediates behavioral responses characteristic of serotonergic psychedelics. AL-LAD induces the head-twitch response in male C57BL/6J mice in an inverted-U-shaped dose-dependent manner. AL-LAD exhibits LSD-like behavioral effects in male C57BL/6J mice.

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CAS. Nr.: 65527-61-9
Formel: C₂₂H₂₇N₃O
Molecular Weight:349.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

AL-LAD Chemical Structure

CAS. Nr.: 65527-61-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

5-HT_2A Receptor

8.1 nM (Ki)

5-HT_2A Receptor

3.4 nM (Ki)

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In Vitro

AL-LAD exhibits high affinity for 5-HT_2A receptors in rat frontal cortex homogenates, with K_i values of 8.1 nM (vs. [³H]ketanserin) and 3.4 nM (vs. [¹²⁵I]-R-DOI)^[1].
AL-LAD binds to D₁ and D₂ dopaminergic receptors in rat tissue homogenates with K_0.5 values of 189 nM and 12.3 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AL-LAD (25-400 μg/kg; i.p.) dose-dependently induces head twitch responses in male C57BL/6J mice, with the maximal response observed at 200 μg/kg and an ED₅₀ of 74.2 μg/kg (174.9 nmol/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 6−8 weeks old)^[1]
Dosage:

25 µg/kg; 50 µg/kg; 100 µg/kg; 200 µg/kg; 400 µg/kg
Administration:

i.p.; single dose
Result:

Dose-dependently induced HTR with an inverted-U-shaped response; maximal response occurred at 200 μg/kg.

Chemical Information

CAS. Nr. 65527-61-9
Molecular Weight 349.47
Formel C₂₂H₂₇N₃O
SMILES

[H][C@@]1(CC2=CNC3=CC=CC4=C23)C4=C[C@H](CN1CC=C)C(N(CC)CC)=O
Synonyms

6-Allyl-6-nor-LSD
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Brandt SD, et al. Return of the lysergamides. Part II: Analytical and behavioural characterization of N -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ). Drug testing and analysis. 2017 Jan;9(1):38-50. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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- In Vivo
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AL-LAD

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