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Referencia número: HY-149812

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AcrB-IN-4

Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.

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No. CAS: 2890177-95-2
Fòrmula: C₂₉H₃₄N₂O₄S
Peso molecular:506.66

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AcrB-IN-4 Chemical Structure

No. CAS: 2890177-95-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

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In Vitro

Efflux pump-IN-4 (compound G11) (8-128 μg/mL) shows outstanding antibacterial synergism with at least one of the antibiotics (ERY, LEV and MIN). Efflux pump-IN-4 show antibacterial synergism with MIN, and reduces the MIC value of LEV by 4-fold at 8 μg/mL^[1].
Efflux pump-IN-4 (50 μM, 100 μM) shows strong inhibitory activity at the lowest concentration of 50 μM, to inhibit Nile Red efflux^[1].
Efflux pump-IN-4 (4-256 μg/mL) does not cause hemolysis of mice red blood cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Efflux pump-IN-4 (compound G11) (128 μg/mL; 72 h) shows no significant and in vivo toxicity against Caenorhabditis elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2890177-95-2
Peso molecular 506.66
Fòrmula C₂₉H₃₄N₂O₄S
SMILES

O=C(N1CCOCC1)C2=CC3=C(C4=C2CCC(C)(C)O4)C=CC=C3OCCCSC5=CC=C(C=C5)N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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