2890177-95-2
Chemical Structure
AcrB-IN-4
- CAS No.: 2890177-95-2
- Formula:C29H34N2O4S
- Molecular Weight:506.66
IUPAC Name: (7-(3-((4-aminophenyl)thio)propoxy)-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromen-5-yl)(morpholino)methanone
InChIKey: AKLNAJNYBBUACV-UHFFFAOYSA-N
SMILES: O=C(N1CCOCC1)C2=CC3=C(C4=C2CCC(C)(C)O4)C=CC=C3OCCCSC5=CC=C(C=C5)N
Biological Activity: Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model[1].
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AcrB-IN-4 | Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model. | |||||||||||||||||||||
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Keywords
