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Cat. No.: HY-15364

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19-nor-1α,25-Dihydroxyvitamin D3

19-nor-1α,25-Dihydroxyvitamin D3 is a vitamin D receptor (VDR) agonist with an EC₅₀ of 4.8 nM. 19-nor-1α,25-Dihydroxyvitamin D3 binds to VDR and promotes gene transcription. 19-nor-1α,25-Dihydroxyvitamin D3 can be used in the research of diseases related to the vitamin D signaling pathway.

For research use only. We do not sell to patients.

CAS No.: 130447-37-9
Formula: C₂₆H₄₄O₃
Molecular Weight:404.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

19-nor-1α,25-Dihydroxyvitamin D3 Chemical Structure

CAS No.: 130447-37-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

19-nor-1α,25-Dihydroxyvitamin D3 (1 μM) binds potently to purified VDR^[1].
19-nor-1α,25-Dihydroxyvitamin D3 potently promotes formation of the active VDR-coactivator complex with an EC₅₀ of 4.8 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 130447-37-9
Molecular Weight 404.63
Formula C₂₆H₄₄O₃
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C[C@@H](C\3)O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ibe K, et al. Design, synthesis, and properties of des-D-ring interphenylene derivatives of 1α,25-dihydroxyvitamin D3. European Journal of Medicinal Chemistry, 2023, 248: 114795.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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