MOR agonist-5 

MOR agonist-5 is a selective and potent mu-opioid receptor (MOR) agonist with an EC₅₀ of 0.25 nM. MOR agonist-5 shows an EC₅₀ of 10 nM for DOR and >10000 nM for KOR and NOR. MOR agonist-5 exerts significant antinociceptive activity. MOR agonist-5 can be used for the research of pain^[1].

MOR agonist-5 (Compound 13) demonstrates weak recruitment of β-arrestin2 with pEC₅₀ of 7.8^[1]. 
MOR agonist-5 shows an EC₅₀ of 10 nM for DOR and >10000 nM for KOR and NOR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MOR agonist-5 (Compound 13) (i.p.) exerts significant antinociceptive activity, with a ED₅₀ of 0.6581 mg/kg in B6129/F1 hybrid mice with hot plate test and its antinociceptive effect is completely antagonized by Naloxone (HY-17417A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

349.47

C₂₂H₂₇N₃O

3085132-31-3

NC(C1=CC(N2[C@H]3CC[C@@H]2CN(CCCC4=CC=CC=C4)C3)=CC=C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Trivedi RR, et al. N-(3-Hydroxyphenyl)-3,8-diazabicyclooctanes as opioid receptors probes. 1. Investigation of the phenolic hydroxyl group. Eur J Med Chem. 2025;298:117991.  [Content Brief]