Search Result
Results for "
quencher
" in MedChemExpress (MCE) Product Catalog:
7
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0040
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Calcein
Maximum Cited Publications
13 Publications Verification
Fluorexon
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Fluorescent Dye
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Others
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Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
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- HY-43520
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Fluorescent Dye
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Others
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BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .
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- HY-D0720
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NSC-151912; L-6868
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Fluorescent Dye
Reactive Oxygen Species (ROS)
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Others
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Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O 2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm .
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- HY-W012642
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DNA Stain
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Others
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2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics .
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- HY-P4931
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MMP
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Cancer
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Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
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- HY-15943
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6-TAMRA
1 Publications Verification
6-Carboxytetramethylrhodamine
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Fluorescent Dye
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Others
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6-TAMRA (6-Carboxytetramethylrhodamine) is a fluorescent dye. 6-TAMRA is often used in combination with 6-FAM (HY-66021) as an acceptor or fluorescence quencher for fluorescence resonance energy transfer (FRET) in biochemical studies such as potassium ion detection and ribonuclease activity assays .
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- HY-123630
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FD&C RED NO. 40; CI 16035
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Environmental Pollutants
Fluorescent Dye
5-HT Receptor
Interleukin Related
Reactive Oxygen Species (ROS)
IFNAR
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Inflammation/Immunology
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Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .
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- HY-D1045
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DABCYL; Para-methyl red
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Fluorescent Dye
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Others
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Dabcyl acid (Dabcyl) is a nonfluorescent chromophore and a quencher. Dabcyl acid can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions .
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- HY-W127703
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Fluorescent Dye
Biochemical Assay Reagents
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Others
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Octadecyl Rhodamine B chloride is an amphiphilic fluorescent probe with both membrane-binding ability and fluorescent properties, which easily forms aggregates in aqueous phase leading to self-quenching. Octadecyl Rhodamine B chloride can be used for cell membrane staining and further applied in membrane biology research. The maximum absorption/emission wavelengths of Octadecyl Rhodamine B chloride monomer in Triton X-100 are 565 nm/585 nm; the absorption peaks of aggregates in water are blue-shifted to 524 nm and 574 nm, with significantly quenched fluorescence .
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- HY-162543
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18:1 Lissamine rhodamine PE
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Fluorescent Dye
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Others
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18:1 Liss Rhod (18:1 Lissamine rhodamine) PE is a fluorescent phospholipid and fluorescent probe.18:1 Liss Rhod PE admixes into phospholipid inks for large-scale monitoring of dip-pen nanolithography-generated lithographic structures via fluorescence microscopy.18:1 Liss Rhod PE undergoes phase separation or self-quenching under certain conditions in thin lipid membrane stacks .
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- HY-P10533
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Tyrosinase
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Others
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Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .
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- HY-D1080
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EDANS
3 Publications Verification
1,5-EDANS
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Fluorescent Dye
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Others
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EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .
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- HY-126823
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PGSK diacetate (5/6-mixture)
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Fluorescent Dye
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Others
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Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe 2+, Cd 2+, Co 2+, Ni 2+, Zn 2+, etc. Phen green SK (PGSK) diacetate chelates Fe 2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively .
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- HY-D2365
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Fluorescent Dye
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Others
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QSY 21 NHS is a dark quencher and an efficient energy transfer acceptor for far-red and near-infrared fluorescent probes. QSY 21 NHS operates at a wavelength range of 540-750 nm and is commonly used in FRET applications. QSY 21 NHS does not fluoresce under normal conditions. The NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides and other amine-containing molecules. QSY 21 NHS can be conjugated with dendritic poly-L-lysine to achieve intramolecular quenching of Cy5 fluorescence .
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- HY-D1030
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Fluorescent Dye
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Others
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Fluorescein Biotin is a fluorescent modulator with avidin and streptavidin binding activity. Fluorescein Biotin binds to the biotin-binding sites of avidin and streptavidin, and this binding induces significant fluorescence quenching .
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- HY-W013205
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Biochemical Assay Reagents
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Others
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Bis(4-nitrophenyl) phosphate is a catalyst for metal micelles and can catalyze the hydrolysis of (4-nitrophenyl) phosphate. Bis(4-nitrophenyl) phosphate is also an effective catalyst for ring-opening polymerization (ROP), which can achieve controlled polymerization of β-butyrolactone (β-BL) ring-opening and can be used to prepare diembedded polymers without quenching. segment copolymer .
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- HY-W923198
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Methacryloyloxy fluorescein
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Fluorescent Dye
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Others
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Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm) .
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- HY-149931
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Fluorescent Dye
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Cancer
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BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging .
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- HY-W013195
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Nucleoside Antimetabolite/Analog
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Cancer
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8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
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- HY-P3749
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Fluorescent Dye
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Others
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Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
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- HY-D1590
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Fluorescent Dye
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Others
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ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .
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- HY-N3103
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Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate
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Tyrosinase
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Inflammation/Immunology
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p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC50=4.89 μg/mL, Ki=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen .
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- HY-W127716
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Fluorescent Dye
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Cancer
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Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .
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- HY-D1555
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Cy7 DBCO
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Fluorescent Dye
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Others
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Cyanine7 DBCO (Cy7 DBCO) is a near-infrared fluorescent dye and an efficient bio-orthogonal quencher. Cyanine7 DBCO is formed by covalent connection of the near-infrared fluorescent dye Cy7 and the dibenzocyclooctyne (DBCO) functional group. After reacting with N3-Cy5-COOH, the fluorescence of Cy5 decreases by 90% within 90 minutes, and rapid signal attenuation can be observed within 2-5 minutes. Cyanine7 DBCO can be used for the study of deep tissue imaging and receptor-targeted therapeutic strategies .
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- HY-154834
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Fluorescent Dye
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Others
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BHQ-1 NHS is a quencher and fluorescent dye. BHQ-1 NHS enables direct labeling via fluorescently labeled nucleotides .
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- HY-P2536
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- HY-D2864
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Fluorescent Dye
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Others
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Aza-CyBz is a selective NaCl-responsive fluorescent probe. Aza-CyBz visualizes plant salt stress by forming ordered aggregates with NaCl, leading to near-infrared fluorescence quenching. Aza-CyBz acts via electrostatic interaction between the cationic cyanine dye and NaCl to form J-aggregates, causing fluorescence quenching with a detection limit of 170 μM .
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- HY-42984
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Biochemical Assay Reagents
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Others
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BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. UBHQ-2 NHS has a wide and intense quenching range from 560-670 nm, which makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-P1853
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- HY-D0142
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Fluorescent Dye
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Others
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Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium acts as a water-soluble fluorescent dye for fluorescence quenching assays monitoring gramicidin ion-channel activity .
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- HY-W007359
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- HY-W130025
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Cholinesterase (ChE)
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Neurological Disease
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p-Xylene bis(pyridinium bromide) (compound 21), a cationic charged quencher, is a week bisquaternary AChE and BChE inhibitor with IC50s of 1540 μM and 529 μM, respectively .
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- HY-P4920
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Fluorescent Dye
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Others
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Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
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- HY-D1682
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Fluorescent Dye
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Others
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NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors .
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- HY-D1050
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6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester
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Fluorescent Dye
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Metabolic Disease
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DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
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- HY-D0929
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α-Naphthol Orange
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Fluorescent Dye
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Others
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Orange I (α-Naphthol Orange) is an anionic azo dye that can form a complex with Methylene blue (HY-14536) and cause fluorescence quenching. The equilibrium constant of the complex of Orange I and Methylene blue is 79900 mol -1·dm 3. Orange I can change the absorption spectrum of itself and Methylene blue .
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- HY-125273
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Fluorescent Dye
Phosphoglycerate Dehydrogenase (PHGDH)
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Others
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DNS-pE is a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor with a Ki of 7.4 μM. DNS-pE selectively and irreversibly covalently modifies endogenous PHGDH in live mammalian cells, its vinyl sulfone moiety acts as a fluorescence quencher that becomes highly fluorescent upon covalent modification of PHGDH. DNS-pE can be used as a fluorescent dye for live-cell imaging .
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- HY-W001952
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Fluorescent Dye
Drug Intermediate
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Others
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6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe that forms a 1:1 or 2:1 complex with β-cyclodextrin (β-CD). 6-Bromo-2-naphthol is capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. RTP probes are a class of small DNA or RNA sequences labeled with fluorescent dyes and quencher molecules, which can be widely used in gene expression analysis, SNP genotyping, and pathogen detection. 6-Bromo-2-naphthol embeds into the cyclodextrin cavity through hydrophobic interactions, inhibits the oxygen quenching effect, and emits a phosphorescent signal at room temperature. 6-Bromo-2-naphthol can also be used as an intermediate for the synthesis of antibacterial azo dyes, and its derivatives show antibacterial activity against Staphylococcus aureus, Escherichia coli and other bacteria .
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- HY-P5485
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Bacterial
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Others
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Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA .
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- HY-D1190
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RAR/RXR
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Others
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DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm) .
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- HY-117245
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- HY-D1080R
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1,5-EDANS (Standard)
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Fluorescent Dye
Reference Standards
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Others
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EDANS (1,5-EDANS) (Standard) is an analytical standard for EDANS. This product is intended for research and analytical applications. EDANS (1,5-EDANS) is a novel quenched fluorogenic substrate for the analysis of retroviral proteases by resonance energy transfer .
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- HY-W007671
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Endogenous Metabolite
Tyrosinase
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Others
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H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols .
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- HY-W142692
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Biochemical Assay Reagents
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Others
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Dodecyl β-D-glucopyranoside is a non-ionic detergent and surfactant commonly used to solubilize and purify membrane proteins in biochemical research. Dodecyl β-D-glucopyranoside also interacts with bovine serum albumin (BSA) to quench its intrinsic fluorescence. The critical micelle concentration (CMC) of Dodecyl β-D-glucopyranoside (DG) and DG/BSA complex is 2.0 mM and 2.34 mM, respectively. Micelles can be formed in aqueous solutions above this concentration .
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- HY-173308
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Fluorescent Dye
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Others
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QSY-21 is a fluorescence quencher. QSY-21 possesses broad absorption in far red and NIR range, and can quench fluorescence of dyes that emit in this region. This is a carboxylic acid derivative. QSY-21 has intense absorption maximum at 661 nm, making it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications. It is a common quencher for Cyanine5, Cyanine5.5, AF 647, or other spectrally similar fluorescent dyes.
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- HY-155786
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TGF-beta/Smad
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Others
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3,7-DMF is an orally active inhibitor of TGF-β1-induced activation of HSCs. 3,7-DMF induces antioxidant genes and quenches ROS away, which can be used to study liver fibrosis .
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- HY-P3123A
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Fluorescent Dye
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Others
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Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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- HY-W110791
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Biochemical Assay Reagents
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Others
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Sodium diphenylamine-4-sulfonate is a chemical indicator commonly used in redox titrations. Its reduced state is colorless and its oxidized state is reddish-purple. Sodium diphenylamine-4-sulfonate is also a quencher and reducing agent. Sodium diphenylamine-4-sulfonate inhibits the electrochemiluminescence of the ruthenium tris(bipyridine) system through energy transfer. Sodium diphenylamine-4-sulfonate participates in the synthesis of nanocrystals .
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- HY-P11302
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CHIKV
Virus Protease
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Infection
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DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .
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- HY-D1045A
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DABCYL sodium; Para-methyl red sodium
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Fluorescent Dye
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Others
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Dabcyl acid sodium (DABCYL sodium) is a nonfluorescent chromophore and a quencher. Dabcyl acid sodium can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions .
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- HY-W112090
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PdTFPP; 5,10,15,20-Tetrakis(pentafluorophenyl)-21H,23H-porphine palladium(II)
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Fluorescent Dye
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Others
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Palladium meso-tetra(pentafluorophenyl)porphyrin (PdTFPP) derives from palladium(II), acting as a fluorescence-quenched optical probe and high-performance oxygen concentration sensor with outstanding photostability and antioxidant capacity. Palladium meso-tetra(pentafluorophenyl)porphyrin exhibits reduced luminescence intensity as dissolved oxygen concentration rises. Palladium meso-tetra(pentafluorophenyl)porphyrin can be applied for real-time monitoring of live-cell respiration, hypoxic tissue imaging, and nanofibrous organic semiconductors in photodetectors for ambient oxygen detection .
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- HY-167632
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(3R,3′S)-Zeaxanthin
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Reactive Oxygen Species (ROS)
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Inflammation/Immunology
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meso-Zeaxanthin accumulates in the central retina and forms macular pigment together with lutein and zeaxanthin, which has the function of light filtering. meso-Zeaxanthin can quench ROS and exert antioxidant function .
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- HY-D2735
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Fluorescent Dye
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Others
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QSY-9-succinimidyl ester is a nonfluorescent acceptor molecule with a terminal NHS ester group. QSY-9-succinimidyl ester has a wide and intense quenching range from 500-600 nm that makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with fluorescent dyes at 500 nm to 600 nm. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-D1663
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Fluorescent Dye
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Others
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APTAB is a fluorescent cationic membrane probe. APTAB locates the anthracene-labeled molecules incorporated into model membranes by fluorescence quenching .
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- HY-D2737
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BHQ-2 DMT amidite
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Fluorescent Dye
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Others
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DMT-BH2 amidite (BHQ-2 DMT amidite) is a black quencher dye for the synthesis of dual-labeled oligonucleotide probes for qPCR bearing 5'-quencher. This quencher is ideal for HEX, JOE, ROX, Cyanine5, and other dyes with emissions in the orange and red parts of the spectrum.
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- HY-D2742
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BHQ-1 DMT amidite
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Fluorescent Dye
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Others
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DMT-BH1 amidite (BHQ-1 DMT amidite) is a true dark quencher with broad absorption curve which covers the visible spectrum with maximum in green to yellow region. It is used for the synthesis of dual labeled oligonucleotide probes for qPCR bearing 5'-quencher DusQ 1 and other FRET applications for multiplexing assays.
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- HY-D2579
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Biochemical Assay Reagents
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Others
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Sulfo DBCO-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission. UBQ-2 effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes .
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- HY-153770
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- HY-N12698
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Others
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Others
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(9Z)-Antheraxanthin is a carotenoid and can be isolated from K. antarctica .
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- HY-126965
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Biochemical Assay Reagents
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Others
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Lipid Y is a potent monosaccharide which contains two bromines per chain. lipid Y binds to a tryptophan residue in a membrane protein and then quenches the fluorescence of the tryptophan residue .
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- HY-P4919
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Beta-secretase
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Others
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Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
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-
- HY-163204
-
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P-glycoprotein
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Cancer
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RhQ-DMB is a potent inhibitor of P-gp. RhQ-DMB exhibits high affinity and inhibitory activity in yeast strains expressing CmABCB1 .
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- HY-W012642A
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DNA Stain
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Others
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2-Aminopurine dihydrochloride is a fluorescent analog of guanosine. 2-Aminopurine dihydrochloride can be used as a fluorescence probe for nucleic acid structure and dynamics. Incorporating 2-Aminopurine dihydrochloride into DNA quenches its fluorescence .
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- HY-118213
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Fluorescent Dye
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Others
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N-(2-Hydroxyethyl)-1,8-naphthalimide is a fluorescent probe for detecting nucleic acids and their precursors. The fluorescence of N-(2-Hydroxyethyl)-1,8-naphthalimide will be quenched by these molecules.
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- HY-D1049
-
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6-((2,4-Dinitrophenyl)amino)hexanoic acid
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Fluorescent Dye
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Metabolic Disease
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DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
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- HY-D1294
-
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Fluorescent Dye
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Cancer
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SY-21 NHS ester is a QSY-21 analog. QSY-21 is a specific quencher against A647. QSY-21 labels polymer. QSY-21 can be used in colon cancer research .
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- HY-P10163
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Fluorescent Dye
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Others
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α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
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- HY-W007671R
-
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Reference Standards
Endogenous Metabolite
Tyrosinase
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Others
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H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols .
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- HY-D2761
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Fluorescent Dye
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Others
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DY-680-NHS ester is an amine reactive hydrophilic fluorochrome. It can be conjugated to an antibody with higher D/P ratio without causing fluorescence quenching and conjugate precipitation, and it is widely used in applications including western blotting, microscopy, flow cytometry, and cell-based assays. The spectrum has an excitation of 690nm and emission at 709nm.
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- HY-P10922
-
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Cathepsin
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Others
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Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence .
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- HY-158235
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Tyrosinase
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Others
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Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC50: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices. .
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- HY-P3123
-
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Fluorescent Dye
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Others
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Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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- HY-W419044A
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Fluorescent Dye
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Others
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Calcein calcium potassium is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
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- HY-W329161
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Fluorescent Dye
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Others
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|
Calcein sodium is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
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-
- HY-D2204
-
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Phosphatase
SHP1
Fluorescent Dye
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Cancer
|
|
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe 3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .
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-
- HY-172309
-
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Fluorescent Dye
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Others
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|
UBQ-3 NHS Ester is a fluroescent agent with a terminal NHS ester group. UBQ-3 NHS Ester has a wide quenching range from 620-730 nm, which makes the compound useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with far-red to near-IR emitting dyes such as Cy5, Cy5.5, Alexa Fluor 633, 647, 700. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-W013205R
-
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Biochemical Assay Reagents
Reference Standards
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Others
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|
Bis(4-nitrophenyl) phosphate (Standard) is the analytical standard of Bis(4-nitrophenyl) phosphate. This product is intended for research and analytical applications. Bis(4-nitrophenyl) phosphate is a catalyst for metal micelles and can catalyze the hydrolysis of (4-nitrophenyl) phosphate. Bis(4-nitrophenyl) phosphate is also an effective catalyst for ring-opening polymerization (ROP), which can achieve controlled polymerization of β-butyrolactone (β-BL) ring-opening and can be used to prepare diembedded polymers without quenching. segment copolymer .
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-
- HY-116762
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Biochemical Assay Reagents
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Others
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|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.
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- HY-D2937
-
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Fluorescent Dye
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Others
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|
BGQFL-9 is a quenched probe. BGQFL-9 can label SNAP tags with successfully labeling all three proteins (GG-SNAP, G132-SNAP, SNAP). BGQFL-9 shows almost no fluorescence .
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-
- HY-D2924
-
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Fluorescent Dye
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Others
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|
CBG-549-QSY7 is a Dylight 549-labeled SNAP tag fluorescent probe (Ex/Em: 546 nm/580 nm), specially designed for non-washable fluorescence imaging applications. CBG-549-QSY7 employs an intramolecular FRET quenching mechanism: intramolecular fluorescence quenching occurs before binding to the SNAP tag, and upon binding, the quenching group is cleaved, releasing fluorescence. The background fluorescence of CBG-549-QSY7 is extremely low, and clear cell membrane images can be obtained after 5 minutes of incubation .
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- HY-D3319
-
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Biochemical Assay Reagents
MMP
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Inflammation/Immunology
Cancer
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BHQ‑3 carboxylic acid is an azo‑containing dark fluorescence quencher. BHQ‑3 carboxylic acid is conjugated to an MMP‑cleavable peptide and paired with a fluorophore to form an activatable probe for MMP activity detection in vitro. BHQ‑3 carboxylic acid shows maximal absorption in the 620 to 730 nm range. BHQ‑3 carboxylic acid–based fluorescent probes can be used in the research of arthritis and tumor‑related pathological processes. .
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- HY-D3206
-
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Fluorescent Dye
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Cancer
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|
CuFS is a reaction-based fluorescent sensor for detecting Cu 2+ with zero background fluorescence. CuFS acts as a fluorescence quencher in the absence of Cu 2+ and as a fluorescence enhancer in the presence of Cu 2+. CuFS can be fabricated into test strips and applied to the detection of Cu 2+ in human cancer cells .
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-
- HY-P11652
-
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Biochemical Assay Reagents
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Others
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Cardiogen is a short biologically active peptide (Ala-Glu-Asp-Arg) that does not bind single-stranded deoxyribooligonucleotides, slightly quenches fluorescence of some double-stranded deoxyribooligonucleotides, strongly quenches fluorescence of methylated and unmethylated λ phage DNA-ethidium bromide complexes .
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-
- HY-203233
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Fluorescent Dye
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Others
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|
Rhodamine-DHPE is a fluorescently labeled phosphatidylethanolamine lipid that labels phospholipid bilayers. Rhodamine-DHPE serves as a fluorescence quenching substrate and membrane stain. The fluorescence lifetime of Rhodamine-DHPE decreases significantly in the presence of Cu 2+-PS complexes. Rhodamine-DHPE effectively stains the membranes of human red blood cells and mouse fibroblasts, and supports lifetime-resolved imaging via pump-probe fluorescence microscopy .
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-
- HY-170466
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1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine
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Biochemical Assay Reagents
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Others
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16:0-12 Doxyl PC (1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine) is a fluorescence quencher, and its nitrogen oxide is located downstream of the sn-2 chain. 16:0-12 Doxyl PC has a better fluorescence quenching effect onthe fluorophore is buried within the hydrocarbon interior of the bilayer .
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- HY-179883
-
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Others
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Metabolic Disease
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16:0-5 Doxyl PC is a phosphocholine with a Doxyl group, which can be used as a membrane probe and a fluorescence quencher in the study of lipid bilayer structures, and is employed to study the membrane transport mediated by phosphatidylinositol translocase.
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- HY-179879
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Others
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Metabolic Disease
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|
16:0-16 Doxyl PC is a phosphocholine with a Doxyl group, which can be used as a membrane probe and a fluorescence quencher in the study of lipid bilayer structures, and is employed to study the membrane transport mediated by phosphatidylinositol translocase.
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- HY-179760
-
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Others
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Metabolic Disease
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|
16:0-7 Doxyl PC is a phosphocholine with a Doxyl group, which can be used as a membrane probe and a fluorescence quencher in the study of lipid bilayer structures, and is employed to study the membrane transport mediated by phosphatidylinositol translocase.
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-
- HY-D3322
-
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Biochemical Assay Reagents
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Others
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|
Sulfo DBCO-UBQ-1 is a click chemistry reagent uniting UBQ-1, which is a dark quencher with a polyaromatic-azo backbone that exhibits no native emission, with a sulfo group for improved hydrophilicity and DBCO for undergoing copper-free click chemistry.
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- HY-D3346
-
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Fluorescent Dye
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Others
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|
Dusquench1 NHS ester is an amino-reactive fluorescent quencher (it does not emit light and has no emission wavelength, Ex = 480-580 nM), specially designed for labeling proteins, oligonucleotides and other biopolymers containing primary amines. It is a core reagent in the fields of qPCR probes, FRET detection and molecular beacons.
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-
- HY-175163
-
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Photosensitizer
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Cancer
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|
TPAPyN is a nitroreductase(NTR)-responsive type I photosensitizer. TPAPyN facilitates the imaging of hypoxic cancer cells and image-guided photodynamic therapy (PDT). TPAPyN does not emit fluorescence in the aqueous environment, but restores when NTR cleaves the nitrofuran quencher with aggregation-induced emission. TPAPyN can be used as a fluorescent probe for specific imaging of hypoxic cancer .
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-
- HY-N12630
-
|
Mycosporine-Gly
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Mitochondrial Metabolism
Bacterial
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Others
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|
Mycosporine glycine (Mycosporine-Gly) is a potent singlet oxygen quencher. Mycosporine glycine can effectively suppress various detrimental effects of the Type-II photosensitization in biological systems, such as inactivation of mitochondrial electron transport, lipid peroxidation of microsomes, hemolysis of erythrocytes and growth inhibition of E.coli. Mycosporine glycine can be used for protecting marine organisms against sunlight damage .
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-
- HY-D3243
-
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Fluorescent Dye
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Others
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|
Mn1 (M1) is a BODIPY-based Mn 2+-selective "turn-on" Fluorescent sensor and fluorescence modulator. In the absence of Mn 2+, Mn1 undergoes fluorescence quenching via photoinduced electron transfer; binding to Mn 2+ inhibits this mechanism, thereby generating a fluorescence "turn-on" response. Mn1 exhibits Mn 2+-specific cellular fluorescence response .
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-
- HY-118720A
-
|
U-23 TFA
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Reactive Oxygen Species (ROS)
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Others
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|
Ovothiol A TFA (U-23 TFA) is an antioxidant. Ovothiol A TFA can be isolated from the tissues of marine invertebrates, algae and fish. Ovothiol A acts synergistically with glutathione to actively scavenge ROS and free radicals, and quench the triplet state of Kynurenic acid (HY-100806), thereby inhibiting oxidative stress and photodamage. OSH is expected to serve as an excellent photoprotective agent to inhibit the harmful effects caused by solar ultraviolet radiation .
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- HY-D3224
-
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Fluorescent Dye
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Neurological Disease
|
|
HCP is a two-photon fluorescent probe capable of crossing the blood-brain barrier, which is specifically designed for real-time detection of hypochlorous acid (HClO/ClO -) produced by myeloperoxidase (MPO). Chlorination of the quinoline skeleton of HCP generates HCP-Cl, which eliminates intramolecular charge transfer (ICT) quenching and thereby produces fluorescence. HCP is suitable for in vivo dynamic imaging of HClO in the brains of epileptic mice and high-throughput screening of antiepileptic drugs (HCP-Cl: Ex/Em = 800 nm/495 nm) .
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- HY-D3347
-
|
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Fluorescent Dye
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Cancer
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|
DUPA-FITC is a fluorescent reagent targeting PSMA, which specifically binds to prostate cancer cells expressing PSMA without non-specific binding to normal blood cells. DUPA-FITC can label PSMA-expressing prostate cancer cells in whole blood, followed by internalization and trafficking to acidic intracellular endosomes, during which the fluorescence is quenched. When combined with flow cytometry and density gradient centrifugation enrichment, DUPA-FITC enables quantitative analysis of circulating tumor cells in peripheral blood samples from prostate cancer patients .
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-
- HY-D3185
-
|
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Fluorescent Dye
Aldehyde Dehydrogenase (ALDH)
|
Cancer
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|
AlDeSense AM is a cell-permeable ALDH1A1-selective fluorescent reporter. AlDeSense AM is oxidized by ALDH1A1, which eliminates photoinduced electron transfer quenching and enhances the fluorescent signal. AlDeSense AM can be used to detect cells with cancer stem cell properties, as well as to monitor the plasticity of cancer stem cells in cell culture systems and animal models. AlDeSense AM is applicable to the study of cancers associated with cancer stem cells, including chronic myeloid leukemia, melanoma, and breast cancer .
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-
- HY-D3269
-
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Fluorescent Dye
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Others
|
|
Mito-Cu (II) is a mitochondria-targeted fluorescent probe (Ex/Em = 370/450 nM). Mito-Cu (II) specifically accumulates in mitochondria of living cells and enables real-time detection of exogenous Cu 2+ within mitochondria of living cells. Mito-Cu (II) achieves "on-off-on" fluorescence switching through sequential exposure to Cu 2+ and ethylenediaminetetraacetic acid (EDTA) (HY-Y0682). Its fluorescence is quenched after forming a 1:1 complex with Cu 2+, and the fluorescence recovers when Cu 2+ is chelated by EDTA .
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-
- HY-DY1091
-
|
Fluorexon (solution)
|
Fluorescent Dye
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Others
|
Calcein (solution) (Fluorexon (solution)) is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
Solvent and concentration: DMSO: 2 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
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-
- HY-D3188
-
|
|
Fluorescent Dye
|
Cancer
|
|
gGlu-2OMe SiR600 is a γ-glutamyl transpeptidase (GGT) responsive fluorescent probe. gGlu-2OMe SiR600 can be converted into a highly fluorescent molecule via reaction with GGT, and its initial fluorescence is quenched through a photoinduced electron transfer (PeT) mechanism. gGlu-2OMe SiR600 exhibits fluorescence activation in malignant breast cancer and benign breast fibroadenoma tissues, enabling lesion visualization. gGlu-2OMe SiR600 can be used for research related to breast cancer and fibroadenoma .
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-
- HY-W086988
-
|
5-Methylbenzotriazole
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Biochemical Assay Reagents
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Others
|
|
5-Methyl-1H-benzotriazole (5-Methylbenzotriazole) is a benzotriazole derivative, and serves as a key building block for ultraviolet absorbers and light stabilizers. 5-Methyl-1H-benzotriazole reduces the photosensitizing ability of nitrate and dissolved organic matter (DOM), enhances the persistence of microorganic pollutants, inhibits the photodegradation of DOM and drug residues, and quenches the triplet excited states of DOM and methotrexate substructures. 5-Methyl-1H-benzotriazole acts as a corrosion inhibitor for copper and copper alloys, and is present in formulations of anti-icing fluids, dishwasher detergents, aircraft deicing fluids and automotive antifreezes .
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-
- HY-123630R
-
|
FD&C RED NO. 40 (Standard); CI 16035 (Standard)
|
Fluorescent Dye
Interleukin Related
5-HT Receptor
IFNAR
Reactive Oxygen Species (ROS)
Reference Standards
|
Inflammation/Immunology
|
|
Allura Red AC (Standard) is an analytical standard of Allura Red AC. This product is intended for research and analytical applications. Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .
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-
- HY-158320
-
|
|
Bacterial
|
Infection
|
|
T3SS-IN-5 (Compound F9) is a specific inhibitor of the type III secretion system (T3SS). T3SS-IN-5 reduces bacterial pathogenicity without affecting bacterial viability by inhibiting the expression of genes associated with T3SS .
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-
- HY-D2768
-
|
|
Fluorescent Dye
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Others
|
|
BP Fluor 430 NHS Ester is a water-soluble, green-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10.
The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 430 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection.
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-
- HY-118159
-
|
DPPP
|
Fluorescent Dye
|
Others
|
|
Diphenyl-1-pyrenylphosphine (DPPP) is a functional organic molecule with both fluorescent properties and metal coordination ability, which is commonly used in materials and coordination chemistry research. Upon exposure to ultraviolet light, Diphenyl-1-pyrenylphosphine undergoes photoinduced phosphorus atom oxidation to form O-DPPP, triggering a transition from aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ). Diphenyl-1-pyrenylphosphine reacts stoichiometrically with lipid hydroperoxides to produce fluorescent diphenyl-1-pyrenylphosphine oxide. Diphenyl-1-pyrenylphosphine can insert into cell membranes to monitor lipid peroxidation processes in living cells .
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-
- HY-Y0678
-
|
TRIMETHYL PHLOROGLUCINOL
|
Biochemical Assay Reagents
|
Others
|
|
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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-
- HY-D2771
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 405 NHS Ester is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10.
The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 405 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection. BP Fluor 405 conjugates can also be used for the detection of abundance targets.
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-
- HY-W127832
-
|
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Fluorescent Dye
|
Others
|
|
Ru(dpp)3(PF6)2 is a complex containing metallic ruthenium (Ru) and is a chemiluminescent oxygen probe. [Ru(dpp)3] 2+ is a luminescent substance that can undergo metal-to-ligand charge transfer (MLCT), and fluorescence will appear during the transfer of Ru to the ligand. At the same time, the fluorescence of Ru(dpp)3(PF6)2 is effectively quenched by molecular oxygen, so it is widely used in biosensors, environmental monitoring, and materials science. The property of Ru(dpp)3(PF6)2, which oxidizes Ru 2+ to Ru 3+, has also been used to design and construct solid-state light-emitting electrochemical cells .
|
-
- HY-D1450
-
|
S01448
|
Fluorescent Dye
|
Cancer
|
|
IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment .
|
-
- HY-Y0678R
-
|
|
Reference Standards
Biochemical Assay Reagents
|
Others
|
|
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl+) and free bromine (Br+). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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-
- HY-N9677
-
|
|
Herbicide
|
Others
|
|
Digalactosyldiacylglycerol is a membrane structure stabilizer that selectively acts on photosystem II light-harvesting complex II (LHCII), serving as a natural bilayer-forming lipid in plant thylakoid membranes. Digalactosyldiacylglycerol constructs a lipid bilayer environment with monogalactosyldiacylglycerol (MGDG) in a 2:1 molar ratio, stabilizing the supramolecular structure of LHCII through interactions such as hydrogen bonding. Its core activity is maintaining thylakoid membrane stacking (grana formation) and supporting photosynthesis-related functions, while also possessing functions in light harvesting assistance and excitation energy quenching regulation under light stress. Digalactosyldiacylglycerol can be used in research on plant photosynthesis mechanisms, thylakoid membrane structure and function regulation, as well as in the construction of artificial photosynthetic systems and the development of plant photoprotection strategies .
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-
- HY-N2452
-
|
|
GLP Receptor
|
Cardiovascular Disease
Infection
Metabolic Disease
|
|
Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions .
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-
- HY-D2745
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection.
BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.
|
-
- HY-D0015
-
|
|
Fluorescent Dye
|
Others
|
|
Cresol red, 97% is an acidic phenolsulfonphthalein triphenylmethane dye. Cresol red, 97% generates reactive oxygen species and singlet oxygen under ultrasonic irradiation, interacts with bovine serum albumin, alters the structure of bovine serum albumin, and oxidizes the fluorescent amino acid residues of bovine serum albumin. Cresol red, 97% can be decolorized and biodegraded by *Absidia spinosa* M15, producing phenylacetic acid and benzoic acid metabolites. Cresol red, 97% serves as a pH indicator (orange at pH 1.8-yellow at pH 2.0, yellow at pH 7.0-purple at pH 8.8). Cresol red, 97% can be used to indicate pH, temperature and salinity .
|
-
- HY-D0916
-
|
YOYO 1; YOYO1
|
Fluorescent Dye
|
Others
|
|
Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).
|
-
- HY-W074143
-
|
|
Fluorescent Dye
|
Others
|
|
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] 2+) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S2O8 2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research .
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-
| Cat. No. |
Product Name |
Type |
-
- HY-D0040
-
Calcein
Maximum Cited Publications
13 Publications Verification
Fluorexon
|
Fluorescent Dyes
|
|
Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
|
-
- HY-43520
-
|
|
Fluorescent Dyes
|
|
BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .
|
-
- HY-D0720
-
|
NSC-151912; L-6868
|
Fluorescent Dyes
|
|
Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O 2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm .
|
-
- HY-W012642
-
|
|
Fluorescent Dyes
|
|
2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics .
|
-
- HY-W074143
-
|
|
Fluorescent Dyes
|
|
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] 2+) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S2O8 2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research .
|
-
- HY-15943
-
6-TAMRA
1 Publications Verification
6-Carboxytetramethylrhodamine
|
Fluorescent Dyes
|
|
6-TAMRA (6-Carboxytetramethylrhodamine) is a fluorescent dye. 6-TAMRA is often used in combination with 6-FAM (HY-66021) as an acceptor or fluorescence quencher for fluorescence resonance energy transfer (FRET) in biochemical studies such as potassium ion detection and ribonuclease activity assays .
|
-
- HY-123630
-
|
FD&C RED NO. 40; CI 16035
|
Fluorescent Dyes
|
|
Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .
|
-
- HY-D1045
-
|
DABCYL; Para-methyl red
|
Fluorescent Dyes
|
|
Dabcyl acid (Dabcyl) is a nonfluorescent chromophore and a quencher. Dabcyl acid can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions .
|
-
- HY-W127703
-
|
|
Fluorescent Dyes
|
|
Octadecyl Rhodamine B chloride is an amphiphilic fluorescent probe with both membrane-binding ability and fluorescent properties, which easily forms aggregates in aqueous phase leading to self-quenching. Octadecyl Rhodamine B chloride can be used for cell membrane staining and further applied in membrane biology research. The maximum absorption/emission wavelengths of Octadecyl Rhodamine B chloride monomer in Triton X-100 are 565 nm/585 nm; the absorption peaks of aggregates in water are blue-shifted to 524 nm and 574 nm, with significantly quenched fluorescence .
|
-
- HY-D1080
-
EDANS
3 Publications Verification
1,5-EDANS
|
Fluorescent Dyes
|
|
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .
|
-
- HY-118159
-
|
DPPP
|
Fluorescent Dyes
|
|
Diphenyl-1-pyrenylphosphine (DPPP) is a functional organic molecule with both fluorescent properties and metal coordination ability, which is commonly used in materials and coordination chemistry research. Upon exposure to ultraviolet light, Diphenyl-1-pyrenylphosphine undergoes photoinduced phosphorus atom oxidation to form O-DPPP, triggering a transition from aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ). Diphenyl-1-pyrenylphosphine reacts stoichiometrically with lipid hydroperoxides to produce fluorescent diphenyl-1-pyrenylphosphine oxide. Diphenyl-1-pyrenylphosphine can insert into cell membranes to monitor lipid peroxidation processes in living cells .
|
-
- HY-D2365
-
|
|
Fluorescent Dyes
|
|
QSY 21 NHS is a dark quencher and an efficient energy transfer acceptor for far-red and near-infrared fluorescent probes. QSY 21 NHS operates at a wavelength range of 540-750 nm and is commonly used in FRET applications. QSY 21 NHS does not fluoresce under normal conditions. The NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides and other amine-containing molecules. QSY 21 NHS can be conjugated with dendritic poly-L-lysine to achieve intramolecular quenching of Cy5 fluorescence .
|
-
- HY-D1030
-
|
|
Fluorescent Dyes
|
|
Fluorescein Biotin is a fluorescent modulator with avidin and streptavidin binding activity. Fluorescein Biotin binds to the biotin-binding sites of avidin and streptavidin, and this binding induces significant fluorescence quenching .
|
-
- HY-W923198
-
|
Methacryloyloxy fluorescein
|
Fluorescent Dyes
|
|
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm) .
|
-
- HY-P3749
-
|
|
Fluorescent Dyes
|
|
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
|
-
- HY-W127716
-
|
|
Fluorescent Dyes
|
|
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .
|
-
- HY-D1555
-
|
Cy7 DBCO
|
Fluorescent Dyes
|
|
Cyanine7 DBCO (Cy7 DBCO) is a near-infrared fluorescent dye and an efficient bio-orthogonal quencher. Cyanine7 DBCO is formed by covalent connection of the near-infrared fluorescent dye Cy7 and the dibenzocyclooctyne (DBCO) functional group. After reacting with N3-Cy5-COOH, the fluorescence of Cy5 decreases by 90% within 90 minutes, and rapid signal attenuation can be observed within 2-5 minutes. Cyanine7 DBCO can be used for the study of deep tissue imaging and receptor-targeted therapeutic strategies .
|
-
- HY-P2536
-
|
|
Fluorescent Dyes
|
|
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .
|
-
- HY-D2864
-
|
|
Fluorescent Dyes
|
|
Aza-CyBz is a selective NaCl-responsive fluorescent probe. Aza-CyBz visualizes plant salt stress by forming ordered aggregates with NaCl, leading to near-infrared fluorescence quenching. Aza-CyBz acts via electrostatic interaction between the cationic cyanine dye and NaCl to form J-aggregates, causing fluorescence quenching with a detection limit of 170 μM .
|
-
- HY-42984
-
|
|
Fluorescent Dyes
|
|
BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. UBHQ-2 NHS has a wide and intense quenching range from 560-670 nm, which makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
|
-
- HY-D0142
-
|
|
Fluorescent Dyes
|
|
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium acts as a water-soluble fluorescent dye for fluorescence quenching assays monitoring gramicidin ion-channel activity .
|
-
- HY-D0916
-
|
YOYO 1; YOYO1
|
Fluorescent Dyes
|
|
Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).
|
-
- HY-D1682
-
|
|
Fluorescent Dyes
|
|
NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors .
|
-
- HY-D1050
-
|
6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester
|
Fluorescent Dyes
|
|
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
|
-
- HY-D1190
-
|
|
Fluorescent Dyes
|
|
DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm) .
|
-
- HY-173308
-
|
|
Fluorescent Dyes
|
|
QSY-21 is a fluorescence quencher. QSY-21 possesses broad absorption in far red and NIR range, and can quench fluorescence of dyes that emit in this region. This is a carboxylic acid derivative. QSY-21 has intense absorption maximum at 661 nm, making it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications. It is a common quencher for Cyanine5, Cyanine5.5, AF 647, or other spectrally similar fluorescent dyes.
|
-
- HY-D2771
-
|
|
Fluorescent Dyes
|
|
BP Fluor 405 NHS Ester is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10.
The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 405 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection. BP Fluor 405 conjugates can also be used for the detection of abundance targets.
|
-
- HY-D0015
-
|
|
Fluorescent Dyes
|
|
Cresol red, 97% is an acidic phenolsulfonphthalein triphenylmethane dye. Cresol red, 97% generates reactive oxygen species and singlet oxygen under ultrasonic irradiation, interacts with bovine serum albumin, alters the structure of bovine serum albumin, and oxidizes the fluorescent amino acid residues of bovine serum albumin. Cresol red, 97% can be decolorized and biodegraded by *Absidia spinosa* M15, producing phenylacetic acid and benzoic acid metabolites. Cresol red, 97% serves as a pH indicator (orange at pH 1.8-yellow at pH 2.0, yellow at pH 7.0-purple at pH 8.8). Cresol red, 97% can be used to indicate pH, temperature and salinity .
|
-
- HY-D1045A
-
|
DABCYL sodium; Para-methyl red sodium
|
Fluorescent Dyes
|
|
Dabcyl acid sodium (DABCYL sodium) is a nonfluorescent chromophore and a quencher. Dabcyl acid sodium can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions .
|
-
- HY-D2735
-
|
|
Fluorescent Dyes
|
|
QSY-9-succinimidyl ester is a nonfluorescent acceptor molecule with a terminal NHS ester group. QSY-9-succinimidyl ester has a wide and intense quenching range from 500-600 nm that makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with fluorescent dyes at 500 nm to 600 nm. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
|
-
- HY-123630R
-
|
FD&C RED NO. 40 (Standard); CI 16035 (Standard)
|
Fluorescent Dyes
|
|
Allura Red AC (Standard) is an analytical standard of Allura Red AC. This product is intended for research and analytical applications. Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .
|
-
- HY-D2745
-
|
|
Fluorescent Dyes
|
|
BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection.
BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.
|
-
- HY-D2737
-
|
BHQ-2 DMT amidite
|
Fluorescent Dyes
|
|
DMT-BH2 amidite (BHQ-2 DMT amidite) is a black quencher dye for the synthesis of dual-labeled oligonucleotide probes for qPCR bearing 5'-quencher. This quencher is ideal for HEX, JOE, ROX, Cyanine5, and other dyes with emissions in the orange and red parts of the spectrum.
|
-
- HY-D2579
-
|
|
Fluorescent Dyes
|
|
Sulfo DBCO-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission. UBQ-2 effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes .
|
-
- HY-W012642A
-
|
|
Fluorescent Dyes
|
|
2-Aminopurine dihydrochloride is a fluorescent analog of guanosine. 2-Aminopurine dihydrochloride can be used as a fluorescence probe for nucleic acid structure and dynamics. Incorporating 2-Aminopurine dihydrochloride into DNA quenches its fluorescence .
|
-
- HY-118213
-
|
|
Fluorescent Dyes
|
|
N-(2-Hydroxyethyl)-1,8-naphthalimide is a fluorescent probe for detecting nucleic acids and their precursors. The fluorescence of N-(2-Hydroxyethyl)-1,8-naphthalimide will be quenched by these molecules.
|
-
- HY-D1049
-
|
6-((2,4-Dinitrophenyl)amino)hexanoic acid
|
Fluorescent Dyes
|
|
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.
|
-
- HY-D2761
-
|
|
Fluorescent Dyes
|
|
DY-680-NHS ester is an amine reactive hydrophilic fluorochrome. It can be conjugated to an antibody with higher D/P ratio without causing fluorescence quenching and conjugate precipitation, and it is widely used in applications including western blotting, microscopy, flow cytometry, and cell-based assays. The spectrum has an excitation of 690nm and emission at 709nm.
|
-
- HY-D2204
-
|
|
Fluorescent Dyes
|
|
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe 3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .
|
-
- HY-D2768
-
|
|
Fluorescent Dyes
|
|
BP Fluor 430 NHS Ester is a water-soluble, green-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10.
The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 430 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection.
|
-
- HY-D2937
-
|
|
Fluorescent Dyes
|
|
BGQFL-9 is a quenched probe. BGQFL-9 can label SNAP tags with successfully labeling all three proteins (GG-SNAP, G132-SNAP, SNAP). BGQFL-9 shows almost no fluorescence .
|
-
- HY-D2924
-
|
|
Fluorescent Dyes
|
|
CBG-549-QSY7 is a Dylight 549-labeled SNAP tag fluorescent probe (Ex/Em: 546 nm/580 nm), specially designed for non-washable fluorescence imaging applications. CBG-549-QSY7 employs an intramolecular FRET quenching mechanism: intramolecular fluorescence quenching occurs before binding to the SNAP tag, and upon binding, the quenching group is cleaved, releasing fluorescence. The background fluorescence of CBG-549-QSY7 is extremely low, and clear cell membrane images can be obtained after 5 minutes of incubation .
|
-
- HY-D3319
-
|
|
Fluorescent Dyes
|
|
BHQ‑3 carboxylic acid is an azo‑containing dark fluorescence quencher. BHQ‑3 carboxylic acid is conjugated to an MMP‑cleavable peptide and paired with a fluorophore to form an activatable probe for MMP activity detection in vitro. BHQ‑3 carboxylic acid shows maximal absorption in the 620 to 730 nm range. BHQ‑3 carboxylic acid–based fluorescent probes can be used in the research of arthritis and tumor‑related pathological processes. .
|
-
- HY-D3206
-
|
|
Fluorescent Dyes
|
|
CuFS is a reaction-based fluorescent sensor for detecting Cu 2+ with zero background fluorescence. CuFS acts as a fluorescence quencher in the absence of Cu 2+ and as a fluorescence enhancer in the presence of Cu 2+. CuFS can be fabricated into test strips and applied to the detection of Cu 2+ in human cancer cells .
|
-
- HY-203233
-
|
|
Fluorescent Dyes
|
|
Rhodamine-DHPE is a fluorescently labeled phosphatidylethanolamine lipid that labels phospholipid bilayers. Rhodamine-DHPE serves as a fluorescence quenching substrate and membrane stain. The fluorescence lifetime of Rhodamine-DHPE decreases significantly in the presence of Cu 2+-PS complexes. Rhodamine-DHPE effectively stains the membranes of human red blood cells and mouse fibroblasts, and supports lifetime-resolved imaging via pump-probe fluorescence microscopy .
|
-
- HY-D3322
-
|
|
Fluorescent Dyes
|
|
Sulfo DBCO-UBQ-1 is a click chemistry reagent uniting UBQ-1, which is a dark quencher with a polyaromatic-azo backbone that exhibits no native emission, with a sulfo group for improved hydrophilicity and DBCO for undergoing copper-free click chemistry.
|
-
- HY-D3346
-
|
|
Fluorescent Dyes
|
|
Dusquench1 NHS ester is an amino-reactive fluorescent quencher (it does not emit light and has no emission wavelength, Ex = 480-580 nM), specially designed for labeling proteins, oligonucleotides and other biopolymers containing primary amines. It is a core reagent in the fields of qPCR probes, FRET detection and molecular beacons.
|
-
- HY-D3243
-
|
|
Fluorescent Dyes
|
|
Mn1 (M1) is a BODIPY-based Mn 2+-selective "turn-on" Fluorescent sensor and fluorescence modulator. In the absence of Mn 2+, Mn1 undergoes fluorescence quenching via photoinduced electron transfer; binding to Mn 2+ inhibits this mechanism, thereby generating a fluorescence "turn-on" response. Mn1 exhibits Mn 2+-specific cellular fluorescence response .
|
-
- HY-D3224
-
|
|
Fluorescent Dyes
|
|
HCP is a two-photon fluorescent probe capable of crossing the blood-brain barrier, which is specifically designed for real-time detection of hypochlorous acid (HClO/ClO -) produced by myeloperoxidase (MPO). Chlorination of the quinoline skeleton of HCP generates HCP-Cl, which eliminates intramolecular charge transfer (ICT) quenching and thereby produces fluorescence. HCP is suitable for in vivo dynamic imaging of HClO in the brains of epileptic mice and high-throughput screening of antiepileptic drugs (HCP-Cl: Ex/Em = 800 nm/495 nm) .
|
-
- HY-D3347
-
|
|
Fluorescent Dyes
|
|
DUPA-FITC is a fluorescent reagent targeting PSMA, which specifically binds to prostate cancer cells expressing PSMA without non-specific binding to normal blood cells. DUPA-FITC can label PSMA-expressing prostate cancer cells in whole blood, followed by internalization and trafficking to acidic intracellular endosomes, during which the fluorescence is quenched. When combined with flow cytometry and density gradient centrifugation enrichment, DUPA-FITC enables quantitative analysis of circulating tumor cells in peripheral blood samples from prostate cancer patients .
|
- HY-D3185
-
|
|
Fluorescent Dyes
|
|
AlDeSense AM is a cell-permeable ALDH1A1-selective fluorescent reporter. AlDeSense AM is oxidized by ALDH1A1, which eliminates photoinduced electron transfer quenching and enhances the fluorescent signal. AlDeSense AM can be used to detect cells with cancer stem cell properties, as well as to monitor the plasticity of cancer stem cells in cell culture systems and animal models. AlDeSense AM is applicable to the study of cancers associated with cancer stem cells, including chronic myeloid leukemia, melanoma, and breast cancer .
|
- HY-D3269
-
|
|
Fluorescent Dyes
|
|
Mito-Cu (II) is a mitochondria-targeted fluorescent probe (Ex/Em = 370/450 nM). Mito-Cu (II) specifically accumulates in mitochondria of living cells and enables real-time detection of exogenous Cu 2+ within mitochondria of living cells. Mito-Cu (II) achieves "on-off-on" fluorescence switching through sequential exposure to Cu 2+ and ethylenediaminetetraacetic acid (EDTA) (HY-Y0682). Its fluorescence is quenched after forming a 1:1 complex with Cu 2+, and the fluorescence recovers when Cu 2+ is chelated by EDTA .
|
- HY-DY1091
-
|
Fluorexon (solution)
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Fluorescent Dyes
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Calcein (solution) (Fluorexon (solution)) is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
Solvent and concentration: DMSO: 2 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
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- HY-D3188
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Fluorescent Dyes
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gGlu-2OMe SiR600 is a γ-glutamyl transpeptidase (GGT) responsive fluorescent probe. gGlu-2OMe SiR600 can be converted into a highly fluorescent molecule via reaction with GGT, and its initial fluorescence is quenched through a photoinduced electron transfer (PeT) mechanism. gGlu-2OMe SiR600 exhibits fluorescence activation in malignant breast cancer and benign breast fibroadenoma tissues, enabling lesion visualization. gGlu-2OMe SiR600 can be used for research related to breast cancer and fibroadenoma .
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| Cat. No. |
Product Name |
Type |
-
- HY-W007359
-
-
- HY-W001952
-
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Biochemical Assay Reagents
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6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe that forms a 1:1 or 2:1 complex with β-cyclodextrin (β-CD). 6-Bromo-2-naphthol is capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. RTP probes are a class of small DNA or RNA sequences labeled with fluorescent dyes and quencher molecules, which can be widely used in gene expression analysis, SNP genotyping, and pathogen detection. 6-Bromo-2-naphthol embeds into the cyclodextrin cavity through hydrophobic interactions, inhibits the oxygen quenching effect, and emits a phosphorescent signal at room temperature. 6-Bromo-2-naphthol can also be used as an intermediate for the synthesis of antibacterial azo dyes, and its derivatives show antibacterial activity against Staphylococcus aureus, Escherichia coli and other bacteria .
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-
- HY-W142692
-
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Biochemical Assay Reagents
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Dodecyl β-D-glucopyranoside is a non-ionic detergent and surfactant commonly used to solubilize and purify membrane proteins in biochemical research. Dodecyl β-D-glucopyranoside also interacts with bovine serum albumin (BSA) to quench its intrinsic fluorescence. The critical micelle concentration (CMC) of Dodecyl β-D-glucopyranoside (DG) and DG/BSA complex is 2.0 mM and 2.34 mM, respectively. Micelles can be formed in aqueous solutions above this concentration .
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-
- HY-W127832
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Biochemical Assay Reagents
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Ru(dpp)3(PF6)2 is a complex containing metallic ruthenium (Ru) and is a chemiluminescent oxygen probe. [Ru(dpp)3] 2+ is a luminescent substance that can undergo metal-to-ligand charge transfer (MLCT), and fluorescence will appear during the transfer of Ru to the ligand. At the same time, the fluorescence of Ru(dpp)3(PF6)2 is effectively quenched by molecular oxygen, so it is widely used in biosensors, environmental monitoring, and materials science. The property of Ru(dpp)3(PF6)2, which oxidizes Ru 2+ to Ru 3+, has also been used to design and construct solid-state light-emitting electrochemical cells .
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- HY-D0015
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Biochemical Assay Reagents
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Cresol red, 97% is an acidic phenolsulfonphthalein triphenylmethane dye. Cresol red, 97% generates reactive oxygen species and singlet oxygen under ultrasonic irradiation, interacts with bovine serum albumin, alters the structure of bovine serum albumin, and oxidizes the fluorescent amino acid residues of bovine serum albumin. Cresol red, 97% can be decolorized and biodegraded by *Absidia spinosa* M15, producing phenylacetic acid and benzoic acid metabolites. Cresol red, 97% serves as a pH indicator (orange at pH 1.8-yellow at pH 2.0, yellow at pH 7.0-purple at pH 8.8). Cresol red, 97% can be used to indicate pH, temperature and salinity .
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- HY-116762
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Biochemical Assay Reagents
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Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.
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- HY-170466
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1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine
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Biochemical Assay Reagents
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16:0-12 Doxyl PC (1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine) is a fluorescence quencher, and its nitrogen oxide is located downstream of the sn-2 chain. 16:0-12 Doxyl PC has a better fluorescence quenching effect onthe fluorophore is buried within the hydrocarbon interior of the bilayer .
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P4931
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MMP
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Cancer
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Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
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-
- HY-P10533
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Tyrosinase
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Others
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Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .
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- HY-P3749
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Fluorescent Dye
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Others
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Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
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-
- HY-P2536
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-
- HY-P1853
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-
- HY-P4920
-
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Fluorescent Dye
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Others
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Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
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-
- HY-P5485
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Bacterial
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Others
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Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA .
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-
- HY-P10461
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Peptides
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Others
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Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM -1s -1), and can be used for detection of proteinase 3 (PR3) activity .
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-
- HY-P3123A
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Fluorescent Dye
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Others
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Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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-
- HY-P11302
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CHIKV
Virus Protease
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Infection
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DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .
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-
- HY-P4940
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Peptides
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Others
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Abz-Val-Asn-Leu-Asp-Ala-Glu-EDDnp is a quenched fluorometric substrate .
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-
- HY-P4919
-
|
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Beta-secretase
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Others
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Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
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-
- HY-P4227A
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Peptides
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Metabolic Disease
|
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WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .
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-
- HY-P10163
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|
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Fluorescent Dye
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Others
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α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
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-
- HY-P10922
-
|
|
Cathepsin
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Others
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Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence .
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-
- HY-P3123
-
|
|
Fluorescent Dye
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Others
|
|
Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
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-
- HY-P11652
-
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Biochemical Assay Reagents
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Others
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Cardiogen is a short biologically active peptide (Ala-Glu-Asp-Arg) that does not bind single-stranded deoxyribooligonucleotides, slightly quenches fluorescence of some double-stranded deoxyribooligonucleotides, strongly quenches fluorescence of methylated and unmethylated λ phage DNA-ethidium bromide complexes .
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-
- HY-K1042
-
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MCE AntiFade Mounting Medium can slow the fluorescence quenching of various common fluorescent dyes with simple operation and good anti-fluorescence quenching effect.
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-
- HY-K1048
-
|
|
|
AntiFade Reagent (with DAPI) is used to slow the fluorescence quenching. The 5 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-Y0678
-
|
TRIMETHYL PHLOROGLUCINOL
|
Structural Classification
Natural Products
Rosaceae
Plants
Rosa rugosa Thunb.
Source Classification
|
Biochemical Assay Reagents
|
|
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
|
-
-
- HY-N3103
-
-
-
- HY-N2452
-
|
|
other families
Classification of Application Fields
Phenols
Polyphenols
Metabolic Disease
Plants
Disease Research Fields
Source Classification
|
GLP Receptor
|
|
Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions .
|
-
-
- HY-117245
-
-
-
- HY-W007671
-
-
-
- HY-Y0678R
-
|
|
Structural Classification
Natural Products
Rosaceae
Plants
Rosa rugosa Thunb.
Source Classification
|
Reference Standards
Biochemical Assay Reagents
|
|
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl+) and free bromine (Br+). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
|
-
-
- HY-N12698
-
-
-
- HY-W007671R
-
-
-
- HY-N12630
-
|
Mycosporine-Gly
|
Structural Classification
Animals
Ketones, Aldehydes, Acids
Source Classification
|
Mitochondrial Metabolism
Bacterial
|
|
Mycosporine glycine (Mycosporine-Gly) is a potent singlet oxygen quencher. Mycosporine glycine can effectively suppress various detrimental effects of the Type-II photosensitization in biological systems, such as inactivation of mitochondrial electron transport, lipid peroxidation of microsomes, hemolysis of erythrocytes and growth inhibition of E.coli. Mycosporine glycine can be used for protecting marine organisms against sunlight damage .
|
-
-
- HY-N9677
-
|
|
Structural Classification
Natural Products
Amaranthaceae
Plants
Spinacia oleracea L.
Source Classification
|
Herbicide
|
|
Digalactosyldiacylglycerol is a membrane structure stabilizer that selectively acts on photosystem II light-harvesting complex II (LHCII), serving as a natural bilayer-forming lipid in plant thylakoid membranes. Digalactosyldiacylglycerol constructs a lipid bilayer environment with monogalactosyldiacylglycerol (MGDG) in a 2:1 molar ratio, stabilizing the supramolecular structure of LHCII through interactions such as hydrogen bonding. Its core activity is maintaining thylakoid membrane stacking (grana formation) and supporting photosynthesis-related functions, while also possessing functions in light harvesting assistance and excitation energy quenching regulation under light stress. Digalactosyldiacylglycerol can be used in research on plant photosynthesis mechanisms, thylakoid membrane structure and function regulation, as well as in the construction of artificial photosynthetic systems and the development of plant photoprotection strategies .
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-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-D1555
-
|
Cy7 DBCO
|
|
DBCO
|
|
Cyanine7 DBCO (Cy7 DBCO) is a near-infrared fluorescent dye and an efficient bio-orthogonal quencher. Cyanine7 DBCO is formed by covalent connection of the near-infrared fluorescent dye Cy7 and the dibenzocyclooctyne (DBCO) functional group. After reacting with N3-Cy5-COOH, the fluorescence of Cy5 decreases by 90% within 90 minutes, and rapid signal attenuation can be observed within 2-5 minutes. Cyanine7 DBCO can be used for the study of deep tissue imaging and receptor-targeted therapeutic strategies .
|
-
- HY-D2579
-
|
|
|
DBCO
|
|
Sulfo DBCO-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission. UBQ-2 effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes .
|
-
- HY-D3322
-
|
|
|
DBCO
|
|
Sulfo DBCO-UBQ-1 is a click chemistry reagent uniting UBQ-1, which is a dark quencher with a polyaromatic-azo backbone that exhibits no native emission, with a sulfo group for improved hydrophilicity and DBCO for undergoing copper-free click chemistry.
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-162543
-
|
18:1 Lissamine rhodamine PE
|
|
Phospholipids
|
|
18:1 Liss Rhod (18:1 Lissamine rhodamine) PE is a fluorescent phospholipid and fluorescent probe.18:1 Liss Rhod PE admixes into phospholipid inks for large-scale monitoring of dip-pen nanolithography-generated lithographic structures via fluorescence microscopy.18:1 Liss Rhod PE undergoes phase separation or self-quenching under certain conditions in thin lipid membrane stacks .
|
-
- HY-W013195
-
|
|
|
Nucleoside Analogs
Adenosine
|
|
8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
|
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