T3SS-IN-5
T3SS-IN-5 (Compound F9) is a specific inhibitor of the type III secretion system (T3SS). T3SS-IN-5 reduces bacterial pathogenicity without affecting bacterial viability by inhibiting the expression of genes associated with T3SS.
For research use only. We do not sell to patients.
- Formula: C16H14N2OS2
- Molecular Weight:314.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
T3SS-IN-5 (200 μM; 48 h) has no statistically significant effect on the viability of Xcc[1].
T3SS-IN-5 (200 μM; 5 d) causes a significant reduction in Xcc-jx-6-induced hypersensitive response (HR) in Nicotiana benthamiana[1].
T3SS-IN-5 (200 μM; 4-7 d) reduces the ulcerative symptoms of orach orange and is more effective than bismerthiazol at the same concentration[1].
T3SS-IN-5 (200 μM; 16 h) significantly reduces the relative incidence of Xcc[1].
T3SS-IN-5 (200 μM; 48 h-5 d) does not affect other virulence factors of Xcc, including extracellular enzymes activity, EPS activity, motility, and biofilm formation[1].
T3SS-IN-5 (100-200 μM; 4 d) combines with Burkholderia anthina hN-8 can further improve the inhibition of Xcc[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hrp cluster
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Concentration:200 μM
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Incubation Time:16 h
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Result:Significantly reduced the expression levels of key T3SS genes (hrpG, hrpX, hrpE, hrcC, hrcT, and hpa1) in the Xcc.
Significantly reduced the expression of the critical disease susceptibility gene, Citrus sinensis lateral organ boundary 1 (CsLOB1).
Chemical Information
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Molecular Weight 314.43
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Formula C16H14N2OS2
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SMILES
OC(C1=NN=C(SCC2=CC=CC=C2)S1)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T3SS-IN-5 Related Classifications
HY-158320 Related Classifications
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