Mca-(ala7,lys(dnp)9)-bradykinin

Name: Mca-(ala7,lys(dnp)9)-bradykinin
Brand: MedChemExpress
SKU: HY-P3749
Rating: 4.5 (0 reviews)

Cat. No.: HY-P3749 Purity: 99.93%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Mca-(ala7,lys(dnp)9)-bradykinin 화학구조

CAS No. : 323577-36-2

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Mca-(ala7,lys(dnp)9)-bradykinin is also a substrate for neprilysin, but is hydrolyzed 10-fold more efficiently by ECE-1, making this substrate selective for ECE-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1388.44

화학식

C₆₆H₈₁N₁₅O₁₉

CAS No.

323577-36-2

Appearance

Solid

Color

Light yellow to yellow

Emission (Em)

460

Excitation (Ex)

380

Sequence Shortening

{MOCAc}-RPPGFSAFK-{DNP}

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (72.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7202 mL	3.6012 mL	7.2023 mL
5 mM	0.1440 mL	0.7202 mL	1.4405 mL
10 mM	0.0720 mL	0.3601 mL	0.7202 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.93%

Select Batch:

Data Sheet (273 KB) SDS (254 KB)

COA (250 KB) LCMS (111 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Johnson GD, et al. Development of an internally quenched fluorescent substrate selective for endothelin-converting enzyme-1. Anal Biochem. 2000 Nov 1;286(1):112-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7202 mL	3.6012 mL	7.2023 mL	18.0058 mL
	5 mM	0.1440 mL	0.7202 mL	1.4405 mL	3.6012 mL
	10 mM	0.0720 mL	0.3601 mL	0.7202 mL	1.8006 mL
	15 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2004 mL
	20 mM	0.0360 mL	0.1801 mL	0.3601 mL	0.9003 mL
	25 mM	0.0288 mL	0.1440 mL	0.2881 mL	0.7202 mL
	30 mM	0.0240 mL	0.1200 mL	0.2401 mL	0.6002 mL
	40 mM	0.0180 mL	0.0900 mL	0.1801 mL	0.4501 mL
	50 mM	0.0144 mL	0.0720 mL	0.1440 mL	0.3601 mL
	60 mM	0.0120 mL	0.0600 mL	0.1200 mL	0.3001 mL