QSY 21 NHS
Based on 1 Customer Validation
QSY 21 NHS is a dark quencher and an efficient energy transfer acceptor for far-red and near-infrared fluorescent probes. QSY 21 NHS operates at a wavelength range of 540-750 nm and is commonly used in FRET applications. QSY 21 NHS does not fluoresce under normal conditions. The NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides and other amine-containing molecules. QSY 21 NHS can be conjugated with dendritic poly-L-lysine to achieve intramolecular quenching of Cy5 fluorescence.
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- Pureté: 95.0%
- CAS No.: 304014-13-9
- Formule: C45H39ClN4O7S
- Masse moléculaire:815.33
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
QSY21-NHS (1:7 Cy5:QSY21 molar ratio; 1 h (serum/GSH); 2 h (caspase-3 assay)) achieves complete FRET quenching of Cy5, maintains stability in serum and GSH, and enables caspase-3-dependent fluorescence activation via cleavage of the DEVD linker[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
QSY 21 NHS (Conjugated to DGLs at a Cy5:QSY 21 molar ratio of 1:7 as part of brain-targeted nano-device; intravenous), as part of the RVG29-modified brain-targeted nano-device, exhibits enhanced accumulation in the brains of healthy mice, with peak brain signal observed 1 hour after intravenous administration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 304014-13-9
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Appearance Solid
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Masse moléculaire 815.33
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Formule C45H39ClN4O7S
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SMILES
O=C(C1CCN(S(=O)(C2=C(C3=C4C=CC(N5C6=C(CC5)C=CC=C6)=CC4=[O+]C7=C3C=CC(N8C9=C(CC8)C=CC=C9)=C7)C=CC=C2)=O)CC1)ON%10C(CCC%10=O)=O.[Cl-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
DMSO : 10 mg/mL (12.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Ben-Nun Y, et al. Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy. Theranostics. 2015;5(8):847-862. Published 2015 Apr 27. [Content Brief]
[2]. Liu Y, et al. Targeted imaging of activated caspase-3 in the central nervous system by a dual functional nano-device. J Control Release. 2012;163(2):203-210. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2265 mL | 6.1325 mL | 12.2650 mL | 30.6624 mL |
| 5 mM | 0.2453 mL | 1.2265 mL | 2.4530 mL | 6.1325 mL | |
| 10 mM | 0.1226 mL | 0.6132 mL | 1.2265 mL | 3.0662 mL |
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