304014-13-9
Chemical Structure
QSY 21 NHS
- CAS No.: 304014-13-9
- Formula:C45H39ClN4O7S
- Molecular Weight:815.33
InChIKey: LZDDKALXTHBHSB-UHFFFAOYSA-M
SMILES: O=C(C1CCN(S(=O)(C2=C(C3=C4C=CC(N5C6=C(CC5)C=CC=C6)=CC4=[O+]C7=C3C=CC(N8C9=C(CC8)C=CC=C9)=C7)C=CC=C2)=O)CC1)ON%10C(CCC%10=O)=O.[Cl-]
Biological Activity: QSY 21 NHS is a dark quencher and an efficient energy transfer acceptor for far-red and near-infrared fluorescent probes. QSY 21 NHS operates at a wavelength range of 540-750 nm and is commonly used in FRET applications. QSY 21 NHS does not fluoresce under normal conditions. The NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides and other amine-containing molecules. QSY 21 NHS can be conjugated with dendritic poly-L-lysine to achieve intramolecular quenching of Cy5 fluorescence[1][2].
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QSY 21 NHS | 95.0% | QSY 21 NHS is a dark quencher and an efficient energy transfer acceptor for far-red and near-infrared fluorescent probes. QSY 21 NHS operates at a wavelength range of 540-750 nm and is commonly used in FRET applications. QSY 21 NHS does not fluoresce under normal conditions. The NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides and other amine-containing molecules. QSY 21 NHS can be conjugated with dendritic poly-L-lysine to achieve intramolecular quenching of Cy5 fluorescence. | ||||||||||||||||||||
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References
- [1]. Ben-Nun Y, et al. Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy. Theranostics. 2015;5(8):847-862. Published 2015 Apr 27. [Content Brief]
- [2]. Liu Y, et al. Targeted imaging of activated caspase-3 in the central nervous system by a dual functional nano-device. J Control Release. 2012;163(2):203-210. [Content Brief]
