2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage MAPK/ERK Pathway Apoptosis
  3. Endogenous Metabolite JAK STAT PPAR p38 MAPK JNK ERK Caspase Apoptosis
  4. Pentadecanoic acid

ペンタデカン酸  (Synonyms: Pentadecanoic acid)

製品番号: HY-W004283 純度: 99.92%
COA 取扱説明書 Technical Support

Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

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Pentadecanoic acid

ペンタデカン酸 構造式

CAS 番号 : 1002-84-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
1 g $25 在庫あり
5 g $50 在庫あり
10 g $70 在庫あり
25 g $120 在庫あり
50 g $170 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Pentadecanoic acid:

ペンタデカン酸 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

JAK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
JAK1 JAK2 JAK3 Tyk2 JAK

STAT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
STAT3 STAT5 STAT6 STAT1

PPAR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PPARα PPARβ/δ PPARγ PPAR PPARδ

p38 MAPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

JNK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
JNK1 JNK2 JNK3 JNK

ERK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ERK ERK1 ERK2 ERK5 ERK8

Caspase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

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  • 参考文献

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製品説明

Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

IC50 & Target

Human Endogenous Metabolite

 

体外実験

Pentadecanoic acid (50-200 μM, 48 hours) induces apoptosis in MCF-7/SC breast cancer stem-like cells by inhibiting the JAK2/STAT3 signaling pathway and suppresses their proliferation and migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ペンタデカン酸 関連抗体

Cell Viability Assay[1]

Cell Line: MCF-7/SC breast cancer stem-like cells
Concentration: 50, 100, 150, 200 μM
Incubation Time: 48 hours
Result: Significantly reduced MCF-7/SC cell viability, showing time- and dose-dependent cytotoxic effects.

Cell Invasion Assay[1]

Cell Line: MCF-7/SC breast cancer stem-like cells
Concentration: 100 μM
Incubation Time: 48 hours
Result: Significantly reduced the ability of MCF-7/SC cells to penetrate Matrigel, with a markedly lower number of invasive cells compared to the control group.

Cell Cycle Analysis[1]

Cell Line: MCF-7/SC breast cancer stem-like cells
Concentration: 50, 100, 150, 200 μM
Incubation Time: 48 hours
Result: Led to a significant accumulation of MCF-7/SC cells in the Sub-G1 phase and reduced the proportion of S-phase and G2/M-phase cells, suggesting cell cycle arrest.
体内実験

Pentadecanoic acid (1% w/w, dietary intake, from gestation to the end of lactation) induces mild glucose intolerance during pregnancy in C57BL6/J mice, partly mediated through activation of PPARα and MAPK signaling pathways, and promoted offspring growth and enhanced antioxidant capacity during lactation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1% Pentadecanoic acid (PA) diet-induced gestational glucose intolerance C57BL6/J mouse model[2]
Dosage: 1% (Pentadecanoic acid ethyl ester was incorporated into a low-fat diet (LFD) by replacing 10 g/kg soybean oil, achieving a final concentration of 1% (w/w), with a total feed composition of 1000 g/kg as an example)
Administration: Dietary intake, from gestation to the end of lactation
Result: Increased PA and heptadecanoic acid (C17:0) levels in maternal and fetal tissues;
Induced mild insulin resistance during pregnancy and activated PPARα and MAPK signaling pathways;
Increased maternal oxidative stress but reduced maternal fat deposition and promoted offspring growth during lactation;
Reduced plasma and liver triglyceride (TG) levels in offspring and enhanced antioxidant capacity.
臨床実験
分子量

242.40

分子式

C15H30O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCCCCCCCCCC)O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 62.5 mg/mL (257.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1254 mL 20.6271 mL 41.2541 mL
5 mM 0.8251 mL 4.1254 mL 8.2508 mL
10 mM 0.4125 mL 2.0627 mL 4.1254 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.94%

COA (238 KB) HNMR (138 KB) RP-HPLC (233 KB) MS (70 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1254 mL 20.6271 mL 41.2541 mL 103.1353 mL
5 mM 0.8251 mL 4.1254 mL 8.2508 mL 20.6271 mL
10 mM 0.4125 mL 2.0627 mL 4.1254 mL 10.3135 mL
15 mM 0.2750 mL 1.3751 mL 2.7503 mL 6.8757 mL
20 mM 0.2063 mL 1.0314 mL 2.0627 mL 5.1568 mL
25 mM 0.1650 mL 0.8251 mL 1.6502 mL 4.1254 mL
30 mM 0.1375 mL 0.6876 mL 1.3751 mL 3.4378 mL
40 mM 0.1031 mL 0.5157 mL 1.0314 mL 2.5784 mL
50 mM 0.0825 mL 0.4125 mL 0.8251 mL 2.0627 mL
60 mM 0.0688 mL 0.3438 mL 0.6876 mL 1.7189 mL
80 mM 0.0516 mL 0.2578 mL 0.5157 mL 1.2892 mL
100 mM 0.0413 mL 0.2063 mL 0.4125 mL 1.0314 mL
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Pentadecanoic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentadecanoic acid1002-84-2Endogenous MetaboliteJAKSTATPPARp38 MAPKJNKERKCaspaseApoptosisJanus kinasePeroxisome proliferator-activated receptorsc-Jun N-terminal kinaseExtracellular signal regulated kinasesMCF-7/SC breast cancer stem-like cellsgestational glucose intolerance C57BL6/J mouseAnti-cancerInhibitorinhibitorinhibit

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