NK1 Antagonist

NK1 Antagonists (19):

Cat. No.	Product Name	Effect	Purity

HY-14751

Rolapitant	Antagonist	98.65%
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM.

HY-101249

L-732138	Antagonist	99.75%
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM.

HY-14405A

Casopitant mesylate	Antagonist	99.84%
Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist.

HY-P3802

[D-Trp2,7,9] Substance P

Antagonist

[D-Trp2,7,9] Substance P is a tachykinin (HY-151413

MEN 10207

Antagonist

MEN 10207 is a selective NK-2 tachykinin receptor (HY-P0061

Vapreotide

Antagonist 98.75%

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P1194

Spantide I

Antagonist 98.97%

Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively.

HY-14406A

L-733060 hydrochloride

Antagonist ≥99.0%

L-733060 hydrochloride is a potent tachykinin NK₁ receptor antagonist.

HY-122347A

Orvepitant maleate

Antagonist 99.99%

Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pK_i of 10.2 for human neurokinin-1 receptor.

HY-108480

SDZ NKT 343

Antagonist

SDZ NKT 343 is a selective, orally active NK₁ receptor antagonist with an IC₅₀ of 0.62 nM against human NK₁ receptor.

HY-19633

CS-003 Free base

Antagonist

CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with K_i values of 2.3 nM, 0.54 nM and 0.74 nM, respectively.

HY-109147

Imnopitant

Antagonist

Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .

HY-P1722

Spantide II

Antagonist

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist.

HY-108479

Nolpitantium

Antagonist

Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK₁ receptor antagonist.

HY-14751A

Rolapitant hydrochloride

Antagonist

Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM.

HY-108481

L-760735

Antagonist

L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC₅₀ of 0.19 nM for human NK1 receptors.

HY-16436

Rolapitant hydrochloride hydrate

Antagonist

Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM.

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P

Antagonist

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist.

HY-19670

Befetupitant

Antagonist

Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.

[email protected]

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