WIN 66306 

WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and NK2 receptors^[1][2].

800.90

C₄₁H₅₂N₈O₉

151928-32-4

Solid

White to off-white

Cyclo(Gly-Trp-Pro-Gly-Val-Gly-{(βR)-β-OH-3-(3-Me-2-Butenyl)-Tyr})

Cyclo(GWPGVG-{(βR)-β-OH-3-(3-Me-2-Butenyl)-Tyr})

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Barrow CJ, et al. WIN 66306, a new neurokinin antagonist produced by an Aspergillus species: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 1994 Nov;47(11):1182-7.  [Content Brief]

  [2]. Barrow C J, et al. Structure, determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-. beta.-hydroxytyrosine isolated from Aspergillus flavipes[J]. Journal of medicinal chemistry, 1994, 37(3): 356-363.  [Content Brief]