2. GPCR/G Protein
    Neuronal Signaling
  3. Neurokinin Receptor
  4. Imnopitant

Imnopitant 

Cat. No.: HY-109147
Handling Instructions

Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .

For research use only. We do not sell to patients.

Imnopitant Chemical Structure

Imnopitant Chemical Structure

CAS No. : 290297-57-3

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Description

Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) [1].

IC50 & Target[1]

NK1

 

In Vitro

Imnopitant is a NK1 receptor antagonist[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

550.54

Formula

C28H28F6N4O
CAS No.
SMILES

O=C(C1=CN=C(N2CCN(C)CC2)C=C1C(C=CC=C3)=C3C)N(C)CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (454.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8164 mL 9.0820 mL 18.1640 mL
5 mM 0.3633 mL 1.8164 mL 3.6328 mL
10 mM 0.1816 mL 0.9082 mL 1.8164 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Imnopitant290297-57-3Neurokinin ReceptorNK receptorTachykinin receptorcoughoveractivebladderalcoholdependencydepressionInhibitorinhibitorinhibit

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