Substance P (4-11)
Substance P (4-11), the C-terminus fragment of Substance P (HY-P0201), is a Substance P agonist that shows highly selective for NK1 receptors.
For research use only. We do not sell to patients.
- CAS No.: 53749-60-3
- Formula: C46H67N11O10S
- Molecular Weight:966.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Substance P (4-11) stimulates significantly the proliferation of human T lymphocytes in vitro at concentrations of 1 nM-100 nM, as assessed by the uptake of [3H]thymidine and [3H]leucine[1].
Substance P (4-11) elicites a strong burst of Luminol (Luminol (HY-15922))-enhanced chemiluminescence with a time course and dose-response curves in human polymorphonuclear leukocytes (PMN)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53749-60-3
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Molecular Weight 966.16
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Formula C46H67N11O10S
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Sequence Shortening
PQQFFGLM-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. D G Payan, et al. Specific stimulation of human T lymphocytes by substance P. J Immunol. 1983 Oct;131(4):1613-5. [Content Brief]
[2]. L Wang, et al. Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells. Am J Physiol. 1995 Jul;269(1 Pt 1):G85-92. [Content Brief]
[3]. P Cornaglia-Ferraris, et al. Sensory neuropeptides (substance P) and 4-11 SP enhance human neutrophils chemiluminescence; the role of L-arginine. Int J Immunopharmacol. 1986;8(4):463-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Substance P (4-11) Related Classifications
HY-P3891 Related Classifications
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