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CD57 Antibody (YA4548)

(Synonyms: NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP)
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CD57 Antibody (YA4548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD57.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    IHC-P, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS with 0.05% sodium azide

  • Conjugation:
    Non-conjugated
  • CD57 Antibody (YA4548) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

CD57 Antibody (YA4548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD57.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 41 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 38 kDa
Immunogen

Purified recombinant fragment of human CD57 (AA: 28-334) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS with 0.05% sodium azide

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD57 is involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group

  • Subcellular Localization

    Golgi apparatus membrane; Single-pass type II membrane protein; Secreted; Golgi apparatus membrane; Single-pass type II membrane protein; Endoplasmic reticulum membrane; Secreted

  • Expression


    Tissue_specificity:Primarily expressed in the brain

  • Isoforms & Post-Translational Modification

    Q9P2W7 has 2 isomers: Q9P2W7-1: 38256 Da (predicted); Q9P2W7-2: 39738 Da (predicted).
    The soluble form derives from the membrane form by proteolytic processing

  • Subunit

    Homodimer. Interacts with SAR1A

  • SwissProt ID

    Q9P2W7

  • Gene ID
    27087 [NCBI]
  • Synonyms

    NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP

CD57 Antibody (YA4548) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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