Ranakinin 

Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion^[1][2][3].

Ranakinin potently binds to and inhibits the binding of selective tachykinin NK1 receptor radioligands to membrane binding sites in rat submandibular glands, with an IC₅₀ of 1.6 nM^[1].
Ranakinin (10^-9-10^-5 M; 20 sec) stimulates the production of IP₃, IP₂ and IP₁ in a time- and dose-dependent manner, and decreases the concentrations of PIP₂ and PIP in a time- and dose-dependent manner, with no effect on PI levels, in myo-[³H]inositol-prelabeled adrenal tissues of Rana ridibunda^[2].
Ranakinin (10^-5 M; 20 min) doubles the secretions of corticosterone and aldosterone from perfused adrenal explants of Rana ridibunda^[2].
Ranakinin (at different competitor concentrations; incubated for 60 min at 25 °C) binds to bufokinin (bNK₁) receptors in intestinal smooth muscle membrane homogenates of Bufo marinus, with an IC₅₀ of 2.8 nM, exhibiting high binding affinity almost comparable to that of bufokinin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1350.59

C₆₂H₉₅N₁₇O₁₅S

139446-71-2

Lys-Pro-Asn-Pro-Glu-Arg-Phe-Tyr-Gly-Leu-Met-NH2

KPNPERFYGLM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. O'Harte F, et al. Ranakinin: a novel NK1 tachykinin receptor agonist isolated with neurokinin B from the brain of the frog Rana ridibunda. J Neurochem. 1991 Dec;57(6):2086-91.  [Content Brief]

  [2]. Kodjo MK, et al. Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland. Endocrinology. 1998;139(2):505-512.  [Content Brief]

  [3]. Liu L, et al. Quantitative structure-activity analyses of bufokinin and other tachykinins at bufokinin (bNK1) receptors of the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2005;69(2):329-338.  [Content Brief]