139446-71-2
Chemical Structure
Ranakinin
- CAS No.: 139446-71-2
- Formula:C62H95N17O15S
- Molecular Weight:1350.59
IUPAC Name: (S)-4-((S)-1-(L-lysyl-L-prolyl-L-asparaginyl)pyrrolidine-2-carboxamido)-5-(((S)-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-oxopentanoic acid
InChIKey: YTZYDDAKFLJJQR-BHEJXMHWSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion[1][2][3].
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Ranakinin | Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion. | |||||||||||||||||||||
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- [1]. O'Harte F, et al. Ranakinin: a novel NK1 tachykinin receptor agonist isolated with neurokinin B from the brain of the frog Rana ridibunda. J Neurochem. 1991 Dec;57(6):2086-91. [Content Brief]
- [2]. Kodjo MK, et al. Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland. Endocrinology. 1998;139(2):505-512. [Content Brief]
- [3]. Liu L, et al. Quantitative structure-activity analyses of bufokinin and other tachykinins at bufokinin (bNK1) receptors of the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2005;69(2):329-338. [Content Brief]
Keywords
