MEN 10207 

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor)?antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively^[1][2].

In competitive radioligand binding assays, MEN 10207 (the IC₅₀ ranges of 21-54 nM) has high affinity in bovine stomach membranes and SKLKB82#3 cells, a murine fibroblast cell line transfected with a cDNA encoding for the bovine NK2 receptor^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

but not Substance P in a dose-dependent manner. And MEN 10207 also effectively blocks the long-term reflex facilitation to the gastrocnemius nerve stimulation^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1109.24

C₅₇H₆₈N₁₄O₁₀

126050-12-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44(2):483-90.  [Content Brief]

  [2]. P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175(1):113-5.  [Content Brief]

  [3]. A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8.  [Content Brief]