2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. MEN 10207

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

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MEN 10207 Chemical Structure

MEN 10207 Chemical Structure

CAS No. : 126050-12-2

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10 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

IC50 & Target[2]

Tachykinin NK2 Receptor

7.9 (pA2)

NK1

5.2 (pA2)

NK3

4.9 (pA2)

In Vitro

In competitive radioligand binding assays, MEN 10207 (the IC50 ranges of 21-54 nM) has high affinity in bovine stomach membranes and SKLKB82#3 cells, a murine fibroblast cell line transfected with a cDNA encoding for the bovine NK2 receptor[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MEN 10207 Related Antibodies
In Vivo

but not Substance P in a dose-dependent manner. And MEN 10207 also effectively blocks the long-term reflex facilitation to the gastrocnemius nerve stimulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Decerebrate, spinalized, unanesthetized Female Sprague-Dawley rats (250-280 g)[1]
Dosage: 7 pmol/10 μL, 70 pmol/10 μL, 700 pmol/10 μL
Administration: Intrathecal administration; once
Result: Blocked the reflex facilitation to intrathecal Neurokinin A, but not Substance P in a dose-dependent manner.
Molecular Weight

1109.24

Formula

C57H68N14O10
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (45.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9015 mL 4.5076 mL 9.0152 mL
5 mM 0.1803 mL 0.9015 mL 1.8030 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9015 mL 4.5076 mL 9.0152 mL 22.5380 mL
5 mM 0.1803 mL 0.9015 mL 1.8030 mL 4.5076 mL
10 mM 0.0902 mL 0.4508 mL 0.9015 mL 2.2538 mL
15 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5025 mL
20 mM 0.0451 mL 0.2254 mL 0.4508 mL 1.1269 mL
25 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.9015 mL
30 mM 0.0301 mL 0.1503 mL 0.3005 mL 0.7513 mL
40 mM 0.0225 mL 0.1127 mL 0.2254 mL 0.5634 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEN 10207126050-12-2MEN10207MEN-10207Neurokinin ReceptorNK receptorTachykinin receptorNK-2 tachykinin receptor antagonistselectiveNeurokinin AInhibitorinhibitorinhibit

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