L-703606
L-703606 is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 144425-84-3
- Formel: C27H29IN2
- Molecular Weight:508.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| TAMH | IC50 |
17.2 μM
Compound: 4; L-703,606
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Cytotoxicity against TAMH assessed as reduction in cell viability by CellTiter-Glo assay
Cytotoxicity against TAMH assessed as reduction in cell viability by CellTiter-Glo assay
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[PMID: 27173385] |
| TAMH | IC50 |
64.28 μM
Compound: 4; L-703,606
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Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 10 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 10 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
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[PMID: 27173385] |
| TAMH | IC50 |
78.19 μM
Compound: 4; L-703,606
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Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 1 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 1 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
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[PMID: 27173385] |
| TAMH | IC50 |
80.9 μM
Compound: 4; L-703,606
|
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 100 nM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 100 nM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
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[PMID: 27173385] |
Chemical Information
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CAS. Nr. 144425-84-3
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Molecular Weight 508.44
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Formel C27H29IN2
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SMILES
IC(C=CC=C1)=C1CN[C@@H](C2CCN3CC2)[C@@H]3C(C4=CC=CC=C4)C5=CC=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Minowa S, et al. Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. Eur J Pharmacol. 2004;486(3):317-324. [Content Brief]
[2]. Francis BE, et al. Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994;45(1):97-103. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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