L-703606 oxalate
L-703606 oxalate is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.
For research use only. We do not sell to patients.
- CAS No.: 351351-06-9
- Formula: C29H31IN2O4
- Molecular Weight:598.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
45.5 μM
Compound: 22; L-703,606 oxalate
|
Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay
Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay
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[PMID: 31260312] |
Chemical Information
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CAS No. 351351-06-9
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Molecular Weight 598.47
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Formula C29H31IN2O4
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SMILES
OC(C(O)=O)=O.IC(C=CC=C1)=C1CN[C@@H](C2CCN3CC2)[C@@H]3C(C4=CC=CC=C4)C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Minowa S, et al. Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. Eur J Pharmacol. 2004;486(3):317-324. [Content Brief]
[2]. Francis BE, et al. Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994;45(1):97-103. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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