L-659874
L-659874 is a selective NK2 receptor antagonist with an IC50 value of 0.49 μM in hamsters. L-659874 inhibits NK2 receptor-mediated hydrolysis of inositol phospholipids. L-659874 could be used for research on the correlation between pain signal transduction and smooth muscle responses.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 125989-15-3
- 分子式: C40H55N9O8S
- 分子量:822.00
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Hamster Bladder NK-2 0.49 μM (IC50) |
L-659874 (preincubated for 15 min prior to stimulation with Eledoisin (HY-P0006); co-incubated with Eledoisin for a total duration of 45 min at 0.01-100 μM) potently inhibits NK2 receptor-mediated Eledoisin-induced phosphatidylinositol hydrolysis in hamster bladder slices, with an IC50 of 0.49 μM[1].
L-659874 blocks the binding of iodine-125-labeled BH-Eledoisin to hamster bladder cell membranes, with an IC50 of 0.04 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 125989-15-3
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分子量 822.00
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分子式 C40H55N9O8S
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SMILES
C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCSC)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3
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配列
Ac-Leu-Met-Gln-Trp-Phe-Gly-NH2
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シーケンスの短縮
Ac-LMQWFG-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L-659874 関連分類
HY-P2593 関連分類
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