[Sar9,Met(O2)11]-Substance P TFA

Name: [Sar9,Met(O2)11]-Substance P TFA
Brand: MedChemExpress
SKU: HY-P1012A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1012A Purity: 98.58%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Sar9,Met(O2)11]-Substance P TFA Chemical Structure

CAS No. : 2828433-10-7

Size	Price	Stock	Quantity
1 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 348	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 624	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1320	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of [Sar9,Met(O2)11]-Substance P TFA:

[Sar9,Met(O2)11]-Substance P In-stock

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

IC₅₀ & Target

NK₁ receptor^[1]

In Vitro

[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1507.68

Formula

C₆₆H₁₀₁F₃N₁₈O₁₇S

CAS No.

2828433-10-7

Appearance

Solid

Color

White to off-white

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2

Sequence Shortening

RPKPQQFF-{Sar}-LM[O2]-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (66.33 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6633 mL	3.3164 mL	6.6327 mL
5 mM	0.1327 mL	0.6633 mL	1.3265 mL
10 mM	0.0663 mL	0.3316 mL	0.6633 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (33.16 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.58%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (241 KB) LCMS (241 KB)

Handling Instructions (2659 KB)

References

[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6633 mL	3.3164 mL	6.6327 mL	16.5818 mL
	5 mM	0.1327 mL	0.6633 mL	1.3265 mL	3.3164 mL
	10 mM	0.0663 mL	0.3316 mL	0.6633 mL	1.6582 mL
	15 mM	0.0442 mL	0.2211 mL	0.4422 mL	1.1055 mL
	20 mM	0.0332 mL	0.1658 mL	0.3316 mL	0.8291 mL
	25 mM	0.0265 mL	0.1327 mL	0.2653 mL	0.6633 mL
	30 mM	0.0221 mL	0.1105 mL	0.2211 mL	0.5527 mL
	40 mM	0.0166 mL	0.0829 mL	0.1658 mL	0.4145 mL
	50 mM	0.0133 mL	0.0663 mL	0.1327 mL	0.3316 mL
	60 mM	0.0111 mL	0.0553 mL	0.1105 mL	0.2764 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.