CD160 Protein, Mouse (HEK293, Fc)

CD160, a versatile receptor on immune cells, orchestrates stimulatory or inhibitory signals crucial for regulating cell activation and differentiation. It exhibits dual forms—GPI-anchored and transmembrane—each presumably initiating distinct signaling pathways. In activated NK cells, CD160 triggers phosphoinositol 3-kinase pathways, while in activated T cells, it engages LCK and CD247/CD3 zeta chain signaling. CD160 serves as a receptor for both classical and non-classical MHC class I molecules, contributing to the intricate regulation of immune responses. Additionally, it functions as a receptor or ligand for TNFRSF14, enabling bidirectional cell-cell contact signaling between antigen-presenting cells and lymphocytes. Upon TNFRSF14 ligation, CD160 provides a stimulatory signal to NK cells, enhancing IFNG production and bolstering anti-tumor immune responses. Conversely, on activated CD4+ T cells, CD160 interacts with TNFRSF14 to down-regulate CD28 costimulatory signaling, thereby constraining memory and alloantigen-specific immune responses. In the context of bacterial infection, CD160 acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. The soluble GPI-cleaved form, often released by activated lymphocytes, likely plays an immune regulatory role by limiting lymphocyte effector functions.