1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Maropitant

Maropitant 

Cat. No.: HY-10053 Purity: 99.00%
Handling Instructions

Maropitant is a neurokinin (NK1) receptor antagonist.

For research use only. We do not sell to patients.

Maropitant Chemical Structure

Maropitant Chemical Structure

CAS No. : 147116-67-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 297 In-stock
Estimated Time of Arrival: December 31
2 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 288 In-stock
Estimated Time of Arrival: December 31
10 mg USD 528 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1056 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Maropitant is a neurokinin (NK1) receptor antagonist. IC50 value: Target: NK1 receptor Maropitant is the first NK1 receptor antagonist developed to treat and prevent emesis in dogs. Treatment with 1 mg/kg Maropitant citrate, significantly reduced the size of ulcerative dermatitis (UD) lesions in mice. Intravenous Maropitant decreased (p < 0.05) MAC by 16% (1.74 ± 0.17%). In contrast, epidural administration of either saline or Maropitant did not change (p > 0.05) the MAC (2.17 ± 0.34% and 1.92 ± 0.12%, respectively).

Molecular Weight

468.67

Formula

C₃₂H₄₀N₂O

CAS No.

147116-67-4

SMILES

CC(C)(C)C1=CC=C(OC)C(CN[[email protected]@H]2[[email protected]](C(C3=CC=CC=C3)C4=CC=CC=C4)N5CCC2CC5)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (71.12 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1337 mL 10.6685 mL 21.3370 mL
5 mM 0.4267 mL 2.1337 mL 4.2674 mL
10 mM 0.2134 mL 1.0668 mL 2.1337 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MaropitantNeurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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Product name:
Maropitant
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HY-10053
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