1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Fosnetupitant

Fosnetupitant (Synonyms: Pronetupitant)

Cat. No.: HY-17615
Handling Instructions

Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor.

For research use only. We do not sell to patients.

Fosnetupitant Chemical Structure

Fosnetupitant Chemical Structure

CAS No. : 1703748-89-3

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Description

Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].

In Vitro

Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated[1].

In Vivo

Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats[1].

Molecular Weight

688.60

Formula

C₃₁H₃₅F₆N₄O₅P

CAS No.

1703748-89-3

SMILES

O=P(OC[N+]1(C)CCN(C2=NC=C(N(C)C(C(C)(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)=O)C(C4=CC=CC=C4C)=C2)CC1)([O-])O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FosnetupitantPronetupitantNeurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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