2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. (R)-Casopitant

(R)-Casopitant  (Synonyms: (R)-GW679769)

Cat. No.: HY-14405B Purity: 98.60%
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(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting.

For research use only. We do not sell to patients.

(R)-Casopitant Chemical Structure

(R)-Casopitant Chemical Structure

CAS No. : 414910-26-2

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5 mg USD 400 In-stock
10 mg USD 640 In-stock
25 mg USD 1300 In-stock
50 mg USD 2100 In-stock
100 mg USD 3360 In-stock
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Based on 1 publication(s) in Google Scholar

(R)-Casopitant Related Antibodies

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Description

(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting[1][2].

Molecular Weight

616.61

Formula

C30H35F7N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)C[C@H](N4CCN(CC4)C(C)=O)CC2)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (81.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6218 mL 8.1089 mL 16.2177 mL
5 mM 0.3244 mL 1.6218 mL 3.2435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6218 mL 8.1089 mL 16.2177 mL 40.5443 mL
5 mM 0.3244 mL 1.6218 mL 3.2435 mL 8.1089 mL
10 mM 0.1622 mL 0.8109 mL 1.6218 mL 4.0544 mL
15 mM 0.1081 mL 0.5406 mL 1.0812 mL 2.7030 mL
20 mM 0.0811 mL 0.4054 mL 0.8109 mL 2.0272 mL
25 mM 0.0649 mL 0.3244 mL 0.6487 mL 1.6218 mL
30 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3515 mL
40 mM 0.0405 mL 0.2027 mL 0.4054 mL 1.0136 mL
50 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.8109 mL
60 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6757 mL
80 mM 0.0203 mL 0.1014 mL 0.2027 mL 0.5068 mL
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(R)-Casopitant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Casopitant414910-26-2(R)-GW679769Neurokinin ReceptorNK receptorTachykinin receptorisomerNK(1)-receptorchemotherapynauseavomitingInhibitorinhibitorinhibit

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