Search Result

Results for "

CC50

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Bacterial (5) Bcr-Abl (1) CHIKV (1) CMV (1) Dengue Virus (2) DNA/RNA Synthesis (11) Drug Metabolite (1) DYRK (1) EBV (1) Endogenous Metabolite (2) Enterovirus (2) Ferroptosis (1) Flavivirus (5) Fungal (2) Glutathione S-transferase (1) HBV (4) HCV (3) HCV Protease (1) Hepatitis E Virus (HEV) (1) HIV (27) HIV Integrase (1) Influenza Virus (10) NF-κB (2) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) Parasite (16) Potassium Channel (1) PROTACs (2) Ras (1) Reference Standards (1) REV-ERB (1) Reverse Transcriptase (3) RSV (3) SARS-CoV (20) TNF Receptor (1) Virus Protease (5)
By Research Areas:	Cancer (9) Infection (93) Inflammation/Immunology (16)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1)

111

Inhibitors & Agonists

Peptides

Natural
Products

Click Chemistry

Oligonucleotides

Targets Recommended: CCR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1123

Auranofin 35+ Cited Publications SKF-39162	Bacterial SARS-CoV	Infection Inflammation/Immunology Cancer
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an *IC₅₀* of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC₅₀ of 4.2 μM for monkey kidney Vero E6 cells.

HY-144645

SP-471P	Flavivirus Dengue Virus Virus Protease DNA/RNA Synthesis	Infection
SP-471P is a potent dengue virus (DENV) protease inhibitor with *EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC₅₀* value over 100 μM. SP-471P can reduce DENV viral RNA synthesis .

HY-164102

TNF-α-IN-18	TNF Receptor NF-κB	Inflammation/Immunology
TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC₅₀ of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a *CC₅₀* >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis .

HY-148170

L-I-OddU	EBV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an *EC₅₀* value of 0.03μM. L-I-OddU has low cytotoxicity with a *CC₅₀* value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .

HY-115574

RSV L-protein-IN-1	RSV	Infection
RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC₅₀=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC₅₀=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .

HY-N6622

Tazettine	Others	Others
Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL) .

HY-157023

RCB16007	Flavivirus	Infection
RCB16007 is a Yellow Fever Virus (YFV) Inhibitor. RCB16007 inhibits the West Nile virus (EC₅₀: 7.9 μM, CC₅₀: 17 μM) .

HY-146045

Antiparasitic agent-7	Parasite	Infection
Antiparasitic agent-7 (compound 5d) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an *IC₅₀* value of 2.85 μM. Antiparasitic agent-7 also has certain cytotoxicity against HepG2 (CC₅₀ = 10.61 μM) .

HY-109571

HZ-1157	Flavivirus Dengue Virus HCV Protease	Infection Inflammation/Immunology
HZ-1157 inhibits HCV NS3/4A protease with an *IC₅₀* of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC₅₀ = 0.15 μM) and is a relatively nontoxic (CC₅₀ > 10 μM) dengue antiviral agent .

HY-B1123R

Auranofin (Standard) SKF-39162 (Standard)	Bacterial SARS-CoV Reference Standards	Infection Inflammation/Immunology Cancer
Auranofin (Standard) is the analytical standard of Auranofin. This product is intended for research and analytical applications. Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2 μM for monkey kidney Vero E6 cells.

HY-157454

Antiviral agent 48	Hepatitis E Virus (HEV)	Infection
Antiviral agent 48 (compound 9m) is a pan-antiviral agent. Antiviral agent 48 has anti-HEV activity and cytotoxicity (EC₉₀=30.6 nM; *CC₅₀*=13.8 nM) .

HY-172223

3-Deazaguanosine C3Guo	SARS-CoV	Infection
3-Deazaguanosine (C3Guo) has potent antiviral activity against SARS-CoV-2 (EC₅₀: 1.14 μM, CC₅₀: >200 μM for Vero E6 cells). 3-Deazaguanosine prevents COVID-19 pneumonia .

HY-139989

NBD-14270	HIV	Infection
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an *IC₅₀* of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC₅₀>100 μM) .

HY-174224

Amb929 ZINC000002782982	SARS-CoV	Infection
Amb929 (ZINC000002782982), a nsp3 ligand, is an anti-SARS-CoV-2 agent. Amb929 inhibits SARS-CoV2-mNG replication in VeroE6 cells with an *EC₅₀* of 34.7 µM. Amb929 has limited and moderate cytotoxicity for VeroE6 cells (CC₅₀: 281 µM). Amb929 also inhibits SARS-CoV-2-mNG replication in Human Airway Epithelium (HAE) .

HY-12108

S 1360	HIV Integrase HIV	Infection
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC₅₀: 20 nM). The EC₅₀, and CC₅₀ of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants .

HY-144730

gp120-IN-1	HIV	Inflammation/Immunology
gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an *IC₅₀* of 2.2 µM and *CC₅₀* of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells .

HY-145850

EV-A71-IN-1	Enterovirus	Infection
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an *EC₅₀* of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC₅₀>56.2 μM) .

HY-146353

HIV-1 inhibitor-29	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an *EC₅₀* of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC₅₀ = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC₅₀ = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS .

HY-146382

WRNA10	HIV	Inflammation/Immunology
WRNA10 is a potent HIV-1 TAR RNA binder with an *IC₅₀* of 10 µM and an *CC₅₀* of 40 µM .

HY-162833

Antileishmanial agent-30	Parasite	Infection
Antileishmanial agent-30 (compound 17k) is a potent inhibitor of leishmania, with the *IC₅₀, CC₅₀, and SI of 0.2 μM, >100 μM and >500 for L. donovani* .

HY-147003

MMV687807	Parasite	Infection
MMV687807 is an anthelmintic agent which has a good activity against *Toxoplasma gondii* (T. gondii) with an *IC₅₀* value of 0.15 μM and a *CC₅₀* value of 1.69 μM .

HY-155709

Antifungal agent 67	Fungal	Infection
Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .

HY-144722

Antitubercular agent-12	Bacterial	Infection
Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .

HY-N12305

4,5-O-Dicaffeoyl quinic acid methyl ester	RSV	Infection
4,5-O-Dicaffeoyl quinic acid methyl ester (compound 4), a dicaffeoylquinic acid, has potent antiviral activity against respiratory syncytial virus (RSV) with an *IC₅₀* of 0.63 μg/mL and a *CC₅₀* of 118.68 μg/mL.

HY-N15562

Batzelladine L	Parasite	Infection
Batzelladine L is a potent *Plasmodium falciparum* inhibitor (IC₅₀= 0.4 μM). Batzelladine L shows moderate cytotoxicity to HepG2 cells (CC₅₀= 14 μM) with antimalarial properties. Batzelladine L is promising for research of antimalarial agents .

HY-155056

SARS-CoV-2 Mpro-IN-7	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-7 (compound 6g) is a potent inhibitor of M ^pro-SARS-CoV-2 (IC₅₀=8.8 μM, *CC₅₀*=10 μM) .

HY-150754

FtsZ-IN-4	Bacterial	Infection
FtsZ-IN-4 is an orally active FtsZ (filamenting temperature-sensitive mutant Z) inhibitor, exhibits excellent antibacterial activity. FtsZ-IN-4 shows good pharmaceutical properties with low cytotoxicity (CC₅₀ >20 μg/mL) .

HY-172123

PRV-IN-1	DNA/RNA Synthesis	Infection
PRV-IN-1 (compound c14) shows significant anti-pseudorabies virus (PRV) potency and safety, with an *EC₅₀* of 14 pM and a *CC₅₀* of 343.7 μM. PRV-IN-1 significantly inhibits the replication of PRV .

HY-163136

Autophagy/REV-ERB-IN-1	Autophagy REV-ERB	Cancer
Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a *CC₅₀* value of 2.3 μM on BTB-474 cells.

HY-162327

PROTAC PAPD5 degrader 1	PROTACs HBV	Infection
PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo , with *IC₅₀* and *CC₅₀* of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells .

HY-144107

HCV-IN-34	HCV	Infection
HCV-IN-34 (compound 3i) is an orally active and potent HCV entry inhibitor. HCV-IN-35 shows excellent antiviral activity, with an *EC₅₀* of 0.010 μM and a *CC₅₀* (half-maximal cytotoxic concentration) of 8.23 μM .

HY-149937

Antimalarial agent 24	Parasite	Infection
Antimalarial agent 24 (Compound 7) is an antimalarial agent in vitro. Antimalarial agent 24 inhibits P. falciparum W2 strain with an *IC₅₀* of 0.81 μM. Antimalarial agent 24 displays a CC₅₀ higher than 200 μM against HepG2 cells .

HY-144109

HCV-IN-36	HCV	Infection
HCV-IN-36 (compound (S)-3h) is an orally active and potent HCV entry inhibitor. HCV-IN-36 shows excellent antiviral activity, with an *EC₅₀* of 0.016 μM and a *CC₅₀* (half-maximal cytotoxic concentration) of 8.78 μM .

HY-N6048

Lancifodilactone F	HIV	Infection
Lancifodilactone F (compound 1) can be isolated from the leaves and stems of Schisandra lancifolia. Lancifodilactone F has anti-HIV activity with *EC₅₀*=20.69 μg/mL. Lancifodilactone F has cytotoxicity against C8166 cells (CC₅₀ >200 μg/mL) .

HY-113860

Antiviral agent 52	HCV	Infection
Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an *EC₅₀* of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with *CC₅₀* of 21.3 μM .

HY-146043

Antiparasitic agent-5	Parasite	Infection
Antiparasitic agent-5 (compound 8h) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an *IC₅₀* value of 2.50 μM. Antiparasitic agent-5 also has certain cytotoxicity against HepG2 (CC₅₀ = 6.78 μM) .

HY-146044

Antiparasitic agent-6	Parasite	Infection
Antiparasitic agent-6 (compound 5b) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an *IC₅₀* value of 3.89 μM. Antiparasitic agent-6 also has certain cytotoxicity against HepG2 (CC₅₀ = 13.64 μM) .

HY-155053

ZIKV-IN-6	Flavivirus DNA/RNA Synthesis	Inflammation/Immunology
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC₅₀＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis .

HY-161820

IAV-IN-3	Influenza Virus	Infection
IAV-IN-3 (Compound (R,S)-16s) is an anti-influenza A virus (IAV) agent (EC₅₀ = 0.134 μM) with weak cytotoxicity (CC₅₀ = 15.35 μM for MDCK cells). IAV-IN-3 inhibits IAV polymerase with an IC₅₀ of 0.045 μM .

HY-146091

HIV-1 inhibitor-34	HIV	Infection
HIV-1 inhibitor-34 (compound 5q) is a potent and selective HIV-1 inhibitor with an *EC₅₀* of 6.4 nM for HIV-1 and a *CC₅₀* of 16 μM in MT-4 cells. HIV-1 inhibitor-34 can be used for researching AIDS .

HY-129152

Ganoderic acid T-N	Influenza Virus	Infection
Ganoderic acid T-N, a triterpenoid, is a H5N1 and H1N1 influenza neuraminidase (NA) inhibitor with *IC₅₀s of 2.7 μM and 42 μM, respectively. Ganoderic acid T-Q shows cytotoxicity against MCF7 cells (CC₅₀=24.4* μM) .

HY-149655

D1N8	SARS-CoV	Infection
D1N8 is a potent SARS-CoV-2 3CL ^pro inhibitor with an IC₅₀ and CC₅₀ values of 0.44 μM and >20 μM, respectively. D1N8 has the potential for the research of anti-SARS-CoV-2 agents targeting 3CL ^pro .

HY-146090

HIV-1 inhibitor-33	HIV	Infection
HIV-1 inhibitor-33 (compound 5n) is a potent and selective HIV-1 inhibitor with an *EC₅₀* of 8.6 nM for HIV-1 and a *CC₅₀* of 18 μM in MT-4 cells. HIV-1 inhibitor-33 can be used for researching AIDS .

HY-161325

Antileishmanial agent-26	Parasite	Infection
Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its *IC₅₀* value against Leishmania donovani is 5.67 μM, and its *CC₅₀* value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases .

HY-179029

RNA polymerase-IN-4	DNA/RNA Synthesis Influenza Virus	Infection
RNA polymerase-IN-4 is a RNA polymerase inhibitor with an *EC₅₀* of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC₅₀ = 3.76 nM), relatively low cytotoxicity (CC₅₀ = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection .

HY-143492

Influenza virus-IN-1	Influenza Virus	Inflammation/Immunology
Influenza virus-IN-1 (compound 14) is a potent influenza A virus inhibitor with an *EC₅₀* of 2.46 µM and *CC₅₀* of >200 µM. Influenza virus-IN-1 shows a concentration dependent inhibition activity for PA_N endonuclease with EC₅₀ of 312.36 nM. Influenza virus-IN-1 shows shows anti-influenza A virus activities .

HY-P10685

T-22 [Tyr5,12,Lys7]-Polyphemusin II	HIV CMV	Infection
T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an *EC₅₀* of 0.008 μg/mL and a *CC₅₀* of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .

HY-143493

Influenza virus-IN-2	Influenza Virus	Inflammation/Immunology
Influenza virus-IN-2 (compound 19) is a potent influenza virus inhibitor with an *EC₅₀* of 2.58 µM and *CC₅₀* of 150.85 µM. Influenza virus-IN-2 shows a concentration dependent inhibition activity for PA_N endonuclease with EC₅₀ of 489.39 nM. Influenza virus-IN-2 shows shows anti-influenza A virus activities .

HY-146364

CI-39	DNA/RNA Synthesis HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an *EC₅₀* of 3.40 μM and an *CC₅₀* of >30 μM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

HY-146042

Antiparasitic agent-4	Parasite	Infection
Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with *IC₅₀s of 8.51 μM and 2.20 μM, respectively. Antiparasitic agent-4 also has certain cytotoxicity against HepG2 (CC₅₀* = 18.97 μM) .

Cat. No.	Product Name	Target	Research Area

HY-P10685

T-22 [Tyr5,12,Lys7]-Polyphemusin II	HIV CMV	Infection
T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an *EC₅₀* of 0.008 μg/mL and a *CC₅₀* of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .

HY-144334

CHIKV-IN-3	CHIKV DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with *EC₅₀* values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC₅₀>100 μM). Prophylactic effect .

HY-P10872

P315V3	SARS-CoV	Infection
P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with *IC₅₀s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC₅₀* of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .

Cat. No.	Product Name		Classification

HY-111640

3'-Azido-3'-deoxy-5-methylcytidine		Azide
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a *CC₅₀* of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an *EC₅₀* of 0.06 μM in peripheral blood mononuclear (PBM) cells . 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-168093

Cetzole		Alkynes
Cetzole (Compound 1) is a ferroptosis inducer that induces cell death through ROS accumulation. The *CC₅₀* values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer .

Cat. No.	Product Name		Classification

HY-148170

L-I-OddU		Nucleoside Analogs Uridine
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an *EC₅₀* value of 0.03μM. L-I-OddU has low cytotoxicity with a *CC₅₀* value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

CC50

Inhibitors & Agonists

Peptides

NaturalProducts

Click Chemistry

Oligonucleotides

Natural
Products