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Cat. No.: HY-144730

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gp120-IN-1

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 2.2 µM and CC₅₀ of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells.

For research use only. We do not sell to patients.

CAS No.: 5948-75-4
Formula: C₁₅H₁₈N₂O₄S
Molecular Weight:322.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

gp120-IN-1 Chemical Structure

CAS No.: 5948-75-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1

2.2 μM (IC₅₀)

HIV-1

100.90 μM (CC₅₀)

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	30 μg/mL Compound: BA21	Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
A549	IC₅₀	>100 μM Compound: 4	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
HCT-116	IC₅₀	>100 μM Compound: 4	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
HT-29	GI₅₀	34.9 μg/mL Compound: BA21	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
MCF7	IC₅₀	>100 μM Compound: 4	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MM1.S	IC₅₀	>100 μM Compound: 4	Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
NCI/ADR-RES	GI₅₀	59.7 μg/mL Compound: BA21	Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
NCI-H460	GI₅₀	180.4 μg/mL Compound: BA21	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
OVCAR-3	GI₅₀	11 μg/mL Compound: BA21	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
PC-3	GI₅₀	72.6 μg/mL Compound: BA21	Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
SUP-T1	CC₅₀	100.9 μM Compound: 4e	Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay	[PMID: 34839157]
U-251	GI₅₀	88.3 μg/mL Compound: BA21	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]

Chemical Information

CAS No. 5948-75-4
Molecular Weight 322.38
Formula C₁₅H₁₈N₂O₄S
SMILES

CCOC(C1=C(NC(NC1C2=CC(OC)=C(C=C2)O)=S)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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gp120-IN-1

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

gp120-IN-1 Related Classifications

HY-144730 Related Classifications