1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. DENV-IN-4

DENV-IN-4 

Cat. No.: HY-115929
Handling Instructions

DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect.

For research use only. We do not sell to patients.

DENV-IN-4 Chemical Structure

DENV-IN-4 Chemical Structure

CAS No. : 2762302-75-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect[1].

IC50 & Target

EC50=4.79 μM (DENV)[1]

In Vitro

DENV-IN-4 (compound 15) (0.064-200 μM; 3 days) has antiviral effect and not related to its toxicity (DENV EC50=4.79 μM, Vero CC50>100, SI>20.9)[1].
DENV-IN-4 (3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7; 48 hours) inhibits the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero[1].
DENV-IN-4 (7.5 and 15 μM; 48 hours) can effectively inhibit DENV infection in Vero cells, and completely inhibited at 15 μM[1].
DENV-IN-4 (0-15 μM; 48 hours) inhibits DENV2 E protein production with good concentration-dependent relationship in Vero cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line: Vero[1]
Concentration: 0.064-200 μM
Incubation Time: 3 days
Result: Showed antiviral effect of DENV-IN-4 was not related to its toxicity (Vero EC50=4.79 μM, CC50>100, SI>20.9).

RT-PCR

Cell Line: Vero, A549 and Huh-7 cells[1]
Concentration: 3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7
Incubation Time: 48 hours
Result: Inhibited the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero.

Western Blot Analysis

Cell Line: Vero[1]
Concentration: 7.5 and 15 μM
Incubation Time: 48 hours
Result: Effectively inhibited DENV infection and completely inhibited at 15 μM.

Immunofluorescence

Cell Line: Vero[1]
Concentration: 0-15 μM
Incubation Time: 48 hours
Result: Inhibited DENV2 E protein production with good concentration-dependent relationship.
Molecular Weight

516.66

Formula

C28H32N4O4Si

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DENV-IN-4
Cat. No.:
HY-115929
Quantity:
MCE Japan Authorized Agent: