Antiparasitic agent-25
Antiparasitic agent-25 (Compounds 11) is an orally active antiparasitic agent. Antiparasitic agent-25 inhibits both parasite invasion and replication ability and has irreversible action against Toxoplasma gondii, significantly reducing the replication rate of Toxoplasma gondii with an IC50 value of 6.33 μM, and demonstrates low cytotoxicity with a CC50 value of 285 μM.
For research use only. We do not sell to patients.
- Formula: C32H29N5O3
- Molecular Weight:531.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 6.33 μM (Toxoplasma gondii)[1]
Antiparasitic agent-25 (10 μM, 24-72 h) reveals irreversible action of against Toxoplasma gondii[1].
Antiparasitic agent-25 (10 μM; 30 min) significantly cut down the number of invaded parasites, indicating it can inhibit the invasion of parasites into host cells[1].
Antiparasitic agent-25 (10 μM, 24 h) constrains the replication of the majority of tachyzoites to 0-1 cycles, manifesting a prevalence of vacuoles sized for accommodating only one or two tachyzoites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HFF cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Constrained the replication of the majority of tachyzoites to 0-1 cycles, manifesting a prevalence of vacuoles sized for accommodating only one or two tachyzoites.
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Cell Line:HFF cells
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Concentration:10 μM
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Incubation Time:30 min
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Result:Significantly cut down the number of invaded parasites, indicating could inhibit the invasion of parasites into host cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Kunming mice (eight-nine weeks old) (Inoculated with 1 × 103 tachyzoites of the RH strain via intraperitoneal (i.p.) injection.)[1]
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Dosage:50 mg/kg (Dissolved in PBS including 25% PEG-400 and 5% DMSO)
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Administration:Oral gavage (p.o.); twice daily for 5 days
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Result:Reduced parasite numbers, statistically significantly extended the median survival time, but insufficient to completely suppress the growth of parasites in vivo, leading to continued infection and consequently high mortality rates among infected mice.
Chemical Information
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Molecular Weight 531.60
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Formula C32H29N5O3
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SMILES
O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)CN3CCN(C(N4C5=CC=CC=C5)=NC6=C(C=CC=C6)C4=O)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiparasitic agent-25 Related Classifications
HY-168959 Related Classifications
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