Cetzole
Cetzole (Compound 1) is a ferroptosis inducer that induces cell death through ROS accumulation. The CC50 values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer.
For research use only. We do not sell to patients.
- CAS No.: 3043764-86-6
- Formula: C11H11NOS
- Molecular Weight:205.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
Cetzole (Compound 1) is a ferroptosis inducer that induces cell death through ROS accumulation. The CC50 values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | CC50 |
3.07 μM
Compound: 1
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Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
|
[PMID: 39264826] |
| MDA-MB-231 | CC50 |
6.28 μM
Compound: 1
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
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[PMID: 39264826] |
| MEF | CC50 |
2.41 μM
Compound: 1
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Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
|
[PMID: 39264826] |
| NCI-H522 | CC50 |
10.31 μM
Compound: 1
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Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
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[PMID: 39264826] |
| NCI-H522 | CC50 |
2.56 μM
Compound: 1
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Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
|
[PMID: 39264826] |
| NCI-H522 | CC50 |
2.71 μM
Compound: 1
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Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
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[PMID: 39264826] |
| U2OS | CC50 |
14.9 μM
Compound: 1
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
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[PMID: 39264826] |
| WI-38 | CC50 |
2.51 μM
Compound: 1
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis
|
[PMID: 39264826] |
Chemical Information
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CAS No. 3043764-86-6
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Molecular Weight 205.28
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Formula C11H11NOS
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SMILES
C#CC1=NC(C2=C(C)C(O)CC2)=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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