Tyrosine kinase-IN-8
Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia.
For research use only. We do not sell to patients.
- Formula: C31H21F2N7O2
- Molecular Weight:561.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Abl1 0.8 μM (CC50) |
Tyrosine kinase-IN-8 (1 and 10 µM, 48 h) shows the best anti-leukemia activity in the K562 cell lines, but is also more toxic to WSS-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 cells and WSS-1 cells
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Concentration:1 and 10 µM
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Incubation Time:48 h
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Result:Reduced cell activity at 10μM but had no obvious cytotoxicity at 1μM.
Chemical Information
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Molecular Weight 561.54
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Formula C31H21F2N7O2
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SMILES
CC(C=CC(N1C(C2=CC=C(F)C=C2)=NOC13C(C=C(F)C=C4)=C4NC3=O)=C5)=C5NC6=NC(C7=CC=CN=C7)=CC=N6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyrosine kinase-IN-8 Related Classifications
HY-162489 Related Classifications
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