2. Anti-infection Cell Cycle/DNA Damage
  3. HIV DNA/RNA Synthesis
  4. DENV-IN-6

DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1IIIB (EC50=0.0181 µM; CC50=64.92 µM).

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DENV-IN-6 Chemical Structure

DENV-IN-6 Chemical Structure

CAS No. : 2375780-95-1

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DENV-IN-6 Related Antibodies

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Description

DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1IIIB (EC50=0.0181 µM; CC50=64.92 µM)[1].

IC50 & Target

HIV (IIIB)

 

In Vitro

DENV-IN-6 (compound 4a) (0.04, 0.2, 1, 5, 25 μM; 5 days) shows inhibitory effect on replication of DENV (I-IV) in a dose-dependent manner (EC50s=17.5, 13.20, 6.8 and 11.41 μM, respectively)[1].
DENV-IN-6 (25 μM; 5 days) shows low toxic to Vero cells (CC50＞200 μM) and exhibits stronger inhibitory effect on DENV-III than on DENV-I, II, IV with a TI value is greater than 29.41 (Therapeutic index (TI): ratio CC50/IC50)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DENV-IN-6 Related Antibodies

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: 0.04, 0.2, 1, 5, 25 μM
Incubation Time: 5 days
Result: Surpressed replication of DENV (I-IV) in a dose-dependent manner and with EC50s of 17.5, 13.20, 6.8 and 11.41 μM, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: Vero cells
Concentration: 25 μM
Incubation Time: 5 days
Result: Exhibited low toxic to Vero cells with a CC50 value was greater than 200 μM.
Showed stronger inhibitory effect on DENV-III than on DENV-I, II, IV (Therapeutic index (TI) values of DENV (I-IV):＞11.43, ＞15.15, ＞29.41, ＞17.53).
Molecular Weight

461.00

Formula

C23H26ClFN4OS
CAS No.
SMILES

CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DENV-IN-6 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DENV-IN-62375780-95-1HIVDNA/RNA SynthesisHuman immunodeficiency virusDENVHIV-1VeroAntiviral activityInhibitorinhibitorinhibit

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