DENV-IN-6
DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1IIIB (EC50=0.0181 µM; CC50=64.92 µM).
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- CAS No.: 2375780-95-1
- Formule: C23H26ClFN4OS
- Masse moléculaire:461.00
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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HIV (IIIB) |
DENV-IN-6 (compound 4a) (0.04, 0.2, 1, 5, 25 μM; 5 days) shows inhibitory effect on replication of DENV (I-IV) in a dose-dependent manner (EC50s=17.5, 13.20, 6.8 and 11.41 μM, respectively)[1].
DENV-IN-6 (25 μM; 5 days) shows low toxic to Vero cells (CC50＞200 μM) and exhibits stronger inhibitory effect on DENV-III than on DENV-I, II, IV with a TI value is greater than 29.41 (Therapeutic index (TI): ratio CC50/IC50)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells
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Concentration:0.04, 0.2, 1, 5, 25 μM
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Incubation Time:5 days
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Result:Surpressed replication of DENV (I-IV) in a dose-dependent manner and with EC50s of 17.5, 13.20, 6.8 and 11.41 μM, respectively.
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Cell Line:Vero cells
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Concentration:25 μM
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Incubation Time:5 days
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Result:Exhibited low toxic to Vero cells with a CC50 value was greater than 200 μM.
Showed stronger inhibitory effect on DENV-III than on DENV-I, II, IV (Therapeutic index (TI) values of DENV (I-IV):＞11.43, ＞15.15, ＞29.41, ＞17.53).
Chemical Information
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CAS No. 2375780-95-1
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Masse moléculaire 461.00
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Formule C23H26ClFN4OS
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SMILES
CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DENV-IN-6 Related Classifications
HY-143273 Related Classifications
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