DENV-IN-6
DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1IIIB (EC50=0.0181 µM; CC50=64.92 µM).
For research use only. We do not sell to patients.
- CAS No.: 2375780-95-1
- Formula: C23H26ClFN4OS
- Molecular Weight:461.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Biological Activity
Description
IC50 & Target
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HIV (IIIB) |
In Vitro
DENV-IN-6 (compound 4a) (0.04, 0.2, 1, 5, 25 μM; 5 days) shows inhibitory effect on replication of DENV (I-IV) in a dose-dependent manner (EC50s=17.5, 13.20, 6.8 and 11.41 μM, respectively)[1].
DENV-IN-6 (25 μM; 5 days) shows low toxic to Vero cells (CC50＞200 μM) and exhibits stronger inhibitory effect on DENV-III than on DENV-I, II, IV with a TI value is greater than 29.41 (Therapeutic index (TI): ratio CC50/IC50)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Vero cells
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Concentration:0.04, 0.2, 1, 5, 25 μM
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Incubation Time:5 days
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Result:Surpressed replication of DENV (I-IV) in a dose-dependent manner and with EC50s of 17.5, 13.20, 6.8 and 11.41 μM, respectively.
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Cell Line:Vero cells
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Concentration:25 μM
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Incubation Time:5 days
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Result:Exhibited low toxic to Vero cells with a CC50 value was greater than 200 μM.
Showed stronger inhibitory effect on DENV-III than on DENV-I, II, IV (Therapeutic index (TI) values of DENV (I-IV):＞11.43, ＞15.15, ＞29.41, ＞17.53).
Chemical Information
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CAS No. 2375780-95-1
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Molecular Weight 461.00
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Formula C23H26ClFN4OS
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SMILES
CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DENV-IN-6 Related Classifications
HY-143273 Related Classifications
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