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Cat. No.: HY-146043

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Antiparasitic agent-5

Antiparasitic agent-5 (compound 8h) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC₅₀ value of 2.50 μM. Antiparasitic agent-5 also has certain cytotoxicity against HepG2 (CC₅₀ = 6.78 μM).

For research use only. We do not sell to patients.

CAS No.: 2494276-55-8
Formula: C₂₀H₁₆ClN₃O₃
Molecular Weight:381.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Antiparasitic agent-5 Chemical Structure

CAS No.: 2494276-55-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC₅₀: 2.50 μM (L. infantum)^[1]

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	6.78 μM Compound: 8h	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay	[PMID: 32590115]
HFF-1	CC₅₀	>64 μM Compound: 8h	Cytotoxicity against human HFF-1 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay Cytotoxicity against human HFF-1 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay	[PMID: 32590115]

Chemical Information

CAS No. 2494276-55-8
Molecular Weight 381.81
Formula C₂₀H₁₆ClN₃O₃
SMILES

O=C1N(CC)C2=C(C=C(Cl)C=C2)C1(O)C(C3=NC(C4=CC=CC=C4)=NO3)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fernandes FS, et al. Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids. Eur J Med Chem. 2020;201:112418. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Antiparasitic agent-5

All Parasite Isoforms